The Milieu Intérieur study - an integrative approach for study of human immunological variance.

Stéphanie Thomas (1) , Vincent Rouilly (1) , Etienne Patin (2) , Cécile Alanio (1) , Annick Dubois (3) , Cécile Delval (3) , Louis-Guillaume Marquier (4) , Nicolas Fauchoux (4) , Seloua Sayegrih (4) , Muriel Vray (5) , Darragh Duffy (1) , Lluis Quintana-Murci (2) , Matthew L Albert (1) , Consortium The Milieu Interieur (6)

1 Immunobiologie des Cellules Dendritiques
2 Génétique Evolutive Humaine - Human Evolutionary Genetics
3 PIRC - Pôle Intégré de Recherche Clinique
4 Biotrial
5 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
6 IP - Institut Pasteur [Paris]

The Milieu Intérieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. Herein, we define the criteria utilized for participant enrollment, and highlight the key data that were collected for correlative studies. In this report, we analyzed biological correlates of sex, age, smoking-habits, metabolic score and CMV infection. We characterized and identified unique risk factors among healthy donors, as compared to studies that have focused on the general population or disease cohorts. Finally, we highlight sex-bias in the thresholds used for metabolic score determination and recommend a deeper examination of current guidelines. In sum, our clinical design, standardized sample collection strategies, and epidemiological data analyses have established the foundation for defining variability within human immune responses.

Mots clés: CMV; Cohort design; Healthy donor; Metabolic syndrome; Baseline serologic data; Immune phenotypes

Domaines: Immunologie

Stéphanie Thomas, Vincent Rouilly, Etienne Patin, Cécile Alanio, Annick Dubois, et al.. The Milieu Intérieur study - an integrative approach for study of human immunological variance.. Clinical Immunology, 2015, 157 (2), pp.277-293. ⟨10.1016/j.clim.2014.12.004⟩. ⟨pasteur-01291879⟩