S. Slovin, S. Keding, and G. Ragupathi, Carbohydrate vaccines as immunotherapy for cancer, Immunology and Cell Biology, vol.22, issue.4, pp.418-428, 2005.
DOI : 10.1016/j.vaccine.2005.01.072

G. Springer, Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy, Journal of Molecular Medicine, vol.75, issue.8, pp.594-602, 1997.
DOI : 10.1007/s001090050144

D. Mazal, R. Lo-man, S. Bay, O. Pritsch, E. Deriaud et al., Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer, Cancer Immunology, Immunotherapy, vol.3, issue.6, pp.1107-1122, 2013.
DOI : 10.1007/s00262-013-1425-7

URL : https://hal.archives-ouvertes.fr/pasteur-00847180

J. Mond, A. Lees, and C. Snapper, T Cell-Independent Antigens Type 2, Annual Review of Immunology, vol.13, issue.1, pp.655-692, 1995.
DOI : 10.1146/annurev.iy.13.040195.003255

R. Lo-man, S. Bay, S. Vichier-guerre, E. Deriaud, D. Cantacuzene et al., A fully synthetic immunogen carrying a carcinoma-associated carbohydrate for active specific immunotherapy, Cancer Res, vol.59, issue.7, pp.1520-1524, 1999.
URL : https://hal.archives-ouvertes.fr/pasteur-00166858

R. Lo-man, S. Vichier-guerre, S. Bay, E. Deriaud, D. Cantacuzene et al., Anti-Tumor Immunity Provided by a Synthetic Multiple Antigenic Glycopeptide Displaying a Tri-Tn Glycotope, The Journal of Immunology, vol.166, issue.4, pp.2849-2854, 2001.
DOI : 10.4049/jimmunol.166.4.2849

URL : https://hal.archives-ouvertes.fr/pasteur-00166855

J. Robinson, J. Halliwell, H. Mcwilliam, R. Lopez, P. Parham et al., The IMGT/HLA database, Nucleic Acids Research, vol.41, issue.D1, pp.1222-1227, 2013.
DOI : 10.1093/nar/gks949

J. Alexander, J. Sidney, S. Southwood, J. Ruppert, C. Oseroff et al., Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides, Immunity, vol.1, issue.9, pp.751-761, 1994.
DOI : 10.1016/S1074-7613(94)80017-0

D. Valmori, A. Pessi, E. Bianchi, and G. Corradin, Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination, J Immunol, vol.149, issue.2, pp.717-721, 1992.

S. Joshi, P. Suresh, and V. Chauhan, Flexibility in MHC and TCR Recognition: Degenerate Specificity at the T Cell Level in the Recognition of Promiscuous Th Epitopes Exhibiting No Primary Sequence Homology, The Journal of Immunology, vol.166, issue.11, pp.6693-6703, 2001.
DOI : 10.4049/jimmunol.166.11.6693

P. Panina-bordignon, A. Tan, A. Termijtelen, S. Demotz, G. Corradin et al., Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells, European Journal of Immunology, vol.3, issue.12, pp.2237-2242, 1989.
DOI : 10.1002/eji.1830191209

B. Boitel, M. Ermonval, P. Panina-bordignon, R. Mariuzza, A. Lanzavecchia et al., Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin- derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition, Journal of Experimental Medicine, vol.175, issue.3, pp.765-777, 1992.
DOI : 10.1084/jem.175.3.765

O. Sullivan, D. Arrhenius, T. , S. J. , D. Guercio et al., On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs, J Immunol, vol.147, issue.8, pp.2663-2669, 1991.

O. Sullivan, D. Sidney, J. Appella, E. Walker, L. Phillips et al., Characterization of the specificity of peptide binding to four DR haplotypes, J Immunol, vol.145, issue.6, pp.1799-1808, 1990.

U. Blank, B. Boitel, D. Mege, M. Ermonval, and O. Acuto, Analysis of tetanus toxin peptide/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma, European Journal of Immunology, vol.46, issue.12, pp.3057-3065, 1993.
DOI : 10.1002/eji.1830231203

A. Pajot, M. Michel, N. Fazilleau, V. Pancre, C. Auriault et al., -knockout mice, European Journal of Immunology, vol.6, issue.11, pp.3060-3069, 2004.
DOI : 10.1002/eji.200425463

URL : https://hal.archives-ouvertes.fr/jpa-00209784

H. Nakada, M. Inoue, N. Tanaka, Y. Numata, H. Kitagawa et al., Expression of the Tn antigen on T-lymphoid cell line Jurkat, Biochemical and Biophysical Research Communications, vol.179, issue.2, pp.762-767, 1991.
DOI : 10.1016/0006-291X(91)91882-D

H. Soule, J. Vazguez, A. Long, S. Albert, and M. Brennan, A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2, JNCI: Journal of the National Cancer Institute, vol.51, issue.5, pp.1409-1416, 1973.
DOI : 10.1093/jnci/51.5.1409

T. Hamilton, R. Young, W. Mckoy, K. Grotzinger, J. Green et al., Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors, Cancer Res, vol.43, issue.11, pp.5379-5389, 1983.

S. Imai, Y. Kiyozuka, H. Maeda, T. Noda, and H. Hosick, Establishment and Characterization of a Human Ovarian Serous Cystadenocarcinoma Cell Line That Produces the Tumor Markers CA-125 and Tissue Polypeptide Antigen, Oncology, vol.47, issue.2, pp.177-184, 1990.
DOI : 10.1159/000226813

T. Hauschka, L. Weiss, B. Holdridge, T. Cudney, M. Zumpft et al., Karyotypic and surface features of murine TA3 carcinoma cells during immunoselection in mice and rats, J Natl Cancer Inst, vol.47, issue.2, pp.343-359, 1971.

S. Bay, C. Leclerc, and R. Lo-man, Method for preparing multiple antigen glycopeptide carbohydrate conjugates, European Patent Application EP, vol.2500, pp.33-34, 2012.

C. Gerard, N. Baudson, T. Ory, and J. Louahed, Tumor Mouse Model Confirms MAGE-A3 Cancer Immunotherapeutic As an Efficient Inducer of Long-Lasting Anti-Tumoral Responses, PLoS ONE, vol.93, issue.6, 2014.
DOI : 10.1371/journal.pone.0094883.s003

P. Allen, D. Strydom, and E. Unanue, Processing of lysozyme by macrophages: identification of the determinant recognized by two T-cell hybridomas., Proceedings of the National Academy of Sciences, vol.81, issue.8, pp.2489-2493, 1984.
DOI : 10.1073/pnas.81.8.2489

S. Swain, D. Dialynas, F. Fitch, and M. English, Monoclonal antibody to L3T4 blocks the function of T cells specific for class 2 major histocompatibility complex antigens, J Immunol, vol.132, issue.3, pp.1118-1123, 1984.

P. Hubert, A. Heitzmann, S. Viel, A. Nicolas, X. Sastre-garau et al., Antibody-Dependent Cell Cytotoxicity Synapses Form in Mice during Tumor-Specific Antibody Immunotherapy, Cancer Research, vol.71, issue.15, pp.5134-5143, 2011.
DOI : 10.1158/0008-5472.CAN-10-4222

URL : https://hal.archives-ouvertes.fr/pasteur-00685062

W. Kruit, S. Suciu, B. Dreno, L. Mortier, C. Robert et al., Selection of Immunostimulant AS15 for Active Immunization With MAGE-A3 Protein: Results of a Randomized Phase II Study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma, Journal of Clinical Oncology, vol.31, issue.19, pp.2413-2420, 2013.
DOI : 10.1200/JCO.2012.43.7111

O. Sullivan, D. , S. J. , D. Guercio, M. Colon et al., Truncation analysis of several DR binding epitopes, J Immunol, vol.146, issue.4, pp.1240-1246, 1991.

E. James, J. Bui, D. Berger, L. Huston, M. Roti et al., Tetramer-guided epitope mapping reveals broad, individualized repertoires of tetanus toxin-specific CD4+ T cells and suggests HLA-based differences in epitope recognition, International Immunology, vol.19, issue.11, pp.1291-1301, 2007.
DOI : 10.1093/intimm/dxm099

R. Lo-man, S. Vichier-guerre, R. Perraut, E. Deriaud, V. Huteau et al., A Fully Synthetic Therapeutic Vaccine Candidate Targeting Carcinoma-Associated Tn Carbohydrate Antigen Induces Tumor-Specific Antibodies in Nonhuman Primates, Cancer Research, vol.64, issue.14, pp.4987-4994, 2004.
DOI : 10.1158/0008-5472.CAN-04-0252

URL : https://hal.archives-ouvertes.fr/pasteur-00166848

B. Boitel, U. Blank, D. Mege, G. Corradin, J. Sidney et al., Strong similarities in antigen fine specificity among DRB1* 1302-restricted tetanus toxin tt830-843-specific TCRs in spite of highly heterogeneous CDR3, J Immunol, vol.154, issue.7, pp.3245-3255, 1995.

R. Faner, E. James, L. Huston, R. Pujol-borrel, W. Kwok et al., Reassessing the role of HLA-DRB3 T-cell responses: Evidence for significant expression and complementary antigen presentation, European Journal of Immunology, vol.120, issue.1, pp.91-102, 2010.
DOI : 10.1002/eji.200939225

R. Chia, F. Achilli, M. Festing, and E. Fisher, The origins and uses of mouse outbred stocks, Nature Genetics, vol.1, issue.11, pp.1181-1186, 2005.
DOI : 10.1002/(SICI)1098-2744(199709)20:1<143::AID-MC16>3.0.CO;2-1

S. Costagliola, M. Many, J. Denef, J. Pohlenz, S. Refetoff et al., Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves??? disease, Journal of Clinical Investigation, vol.105, issue.6, pp.803-811, 2000.
DOI : 10.1172/JCI7665

L. Elia, C. Mennuni, M. Storto, S. Podda, F. Calvaruso et al., Genetic vaccines against Ep-CAM break tolerance to self in a limited subset of subjects: Initial identification of predictive biomarkers, European Journal of Immunology, vol.78, issue.5, pp.1337-1349, 2006.
DOI : 10.1002/eji.200535514

G. Doxiadis, A. De-vos-rouweler, N. De-groot, N. Otting, and R. Bontrop, DR haplotype diversity of the cynomolgus macaque as defined by its transcriptome, Immunogenetics, vol.81, issue.1, pp.31-37, 2012.
DOI : 10.1007/s00251-011-0561-5

G. Andersson, Evolution of the human HLA-DR region, Frontiers in Bioscience, vol.3, issue.4, pp.739-745, 1998.
DOI : 10.2741/A317

J. Trowsdale, ?Both man & bird & beast?: comparative organization of MHC genes, Immunogenetics, vol.23, issue.5, pp.1-17, 1995.
DOI : 10.1007/BF00188427

M. Moro, V. Cecconi, C. Martinoli, E. Dallegno, B. Giabbai et al., Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen-or tumour-derived synthetic peptides, BMC Immunology, vol.6, issue.1, pp.24-34, 2005.
DOI : 10.1186/1471-2172-6-24

URL : https://hal.archives-ouvertes.fr/inserm-00089280

B. Slierendregt, N. Otting, M. Jonker, and R. Bontrop, Gel electrophoretic analysis of rhesus macaque major histocompatibility complex class II DR molecules, Human Immunology, vol.40, issue.1, pp.33-40, 1994.
DOI : 10.1016/0198-8859(94)90019-1

R. Bontrop, N. Otting, N. De-groot, and G. Doxiadis, Major histocompatibility complex class II polymorphisms in primates, Immunological Reviews, vol.51, issue.1, pp.339-350, 1999.
DOI : 10.1111/j.1744-313X.1994.tb00177.x

M. Khazand, C. Peiberg, M. Nagy, and U. Sauermann, Mhc-DQ-DRB haplotype analysis in the rhesus macaque: evidence for a number of different haplotypes displaying a low allelic polymorphism, Tissue Antigens, vol.18, issue.6, pp.615-624, 1999.
DOI : 10.1016/S0167-5699(97)01238-3

G. Doxiadis, A. Rouweler, N. De-groot, A. Louwerse, N. Otting et al., Extensive sharing of MHC class II alleles between rhesus and cynomolgus macaques, Immunogenetics, vol.10, issue.4, pp.259-268, 2006.
DOI : 10.1007/s00251-006-0083-8

G. Doxiadis, N. De-groot, N. De-groot, G. Rotmans, A. De-vos-rouweler et al., Extensive DRB region diversity in cynomolgus macaques: recombination as a driving force, Immunogenetics, vol.81, issue.3, pp.137-147, 2010.
DOI : 10.1007/s00251-010-0422-7

N. Morita, Y. Yajima, H. Asanuma, H. Nakada, and Y. Fujita-yamaguchi, Inhibition of cancer cell growth by anti-Tn monoclonal antibody MLS128, Biosci Trends, vol.3, issue.1, pp.32-37, 2009.