Comparative Anatomy of Phagocytic and immunological Synapses - Archive ouverte HAL Access content directly
Journal Articles Frontiers in Immunology Year : 2016

Comparative Anatomy of Phagocytic and immunological Synapses

(1) , (2) , (2)
1
2

Abstract

The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types. However, growing experimental evidence shows that a very close series of molecular and cellular events control these two processes. Thus, the tight and dynamic interplay between receptor signaling, actin and microtubule cytoskeleton, and targeted vesicle traffic are all critical features to build functional phagosomes and immunological synapses. Interestingly, both phagocytic cups and immunological synapses display particular spatial and temporal patterns of receptors and signaling molecules, leading to the notion of " phagocytic synapse. " Here, we discuss both types of structures, their organization, and the mechanisms by which they are generated and regulated.
Fichier principal
Vignette du fichier
fimmu-07-00018.pdf (484.43 Ko) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

pasteur-01286933 , version 1 (11-03-2016)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Florence Niedergang, Vincenzo Di Bartolo, Andrés Alcover. Comparative Anatomy of Phagocytic and immunological Synapses. Frontiers in Immunology, 2016, ⟨10.3389/fimmu.2016.00018⟩. ⟨pasteur-01286933⟩
295 View
436 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More