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PMP70 (green), and DAPI (blue) staining of Pjvk +/+ (left panel) and Pjvk -/-(right panel) mouse embryonic fibroblasts (MEFs), treated with 0.5 mM H 2 O 2 for 4 hours or left untreated, and analyzed 18 hours later. H 2 O 2 -treatment increases the number of peroxisomes only in the Pjvk +/+ cells (see quantification in Figure 5C) (B) Larger numbers and enlargement of peroxisomes in transfected HeLa cells producing wild-type and mutant forms of pejvakin, respectively. In cells producing EGFP alone, EGFP and wild-type pejvakin (Pjvk), or EGFP and the p.T54I, p.R183W, p.C343S, or p.V330Lfs*7 mutated forms of pejvakin, peroxisomes were identified on the basis of their PMP70- immunoreactivity. The upper panel shows F-actin (red), DAPI (dark blue), EGFP (green), and PMP70 (light blue) staining, whereas the lower panel shows only the PMP70 immunostaining of individual cells delimited by a white border. The number of peroxisomes is larger in cells producing wild-type pejvakin, and smaller in the cells producing any of the mutated forms of pejvakin, than in cells producing EGFP alone (see quantification in Figure 5D), Proliferation of peroxisomes induced by H 2 O 2 in Pjvk + addition, cells producing the mutated forms of pejvakin contain enlarged peroxisomes (arrowheads, and see insets for magnification; see also quantification in Figure 5D). Scale bar is 20 µm in (A) and 10 µm in (B) ,
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