. Hepatology, site investigator) ; Gianandrea Borgherini, MD (Infectious Diseases, site investigator

P. Poubeau and . Md, Infectious Diseases, site investigator) Olivier Fels (Medical Information, 5 data collection)

M. Michault, Microbiology, study design, biological analysis, data collection, Head of steering committee, 7 publication committees) ; Paul Finielz, MD (Nephrology and Dialysis, site investigator)

. Bintner, MD (Neuroradiology, site investigator, steering committee)

S. Blanc and . Neuroradiology, site 10 investigator) ; Michel Renouil, MD (Pediatrics, site investigator, steering committee), Saguiraly Piyaraly, Pediatrics, site investigator, issue.11

F. Paganin and . Md, PhD (Pulmonology, site investigator) ; Frédérik 12

M. Staikowsky and P. , Emergencies Unit, site investigator, steering committee)

M. Cassou, Emergencies Unit, site investigator)

M. Boumahni, Pediatric Intensive Care, site investigator, steering committee)

E. Antok, 16 MD (Neurointensive Care, site investigator)

V. Boisson, Medical Intensive Care, site investigator, steering committee)

C. Mondor, Frédérik Staikowsky, MD, PhD (Anesthesiology, 21 publication committee), pp.67000-67022

F. Schramm and P. Md, EA 7290, publication committee) ; F-97400 Saint Denis Cedex, p.23

S. Larrieu and P. , CIRE Océan Indien, data collection, advisory committee) ; Daouda Sissoko, MD, MPH 24 (CIRE Océan Indien, data collection, advisory committee), Thérèse Couderc, PhD (steering and publication committees)

R. Breiman and A. Powers, Chikungunya fever: an epidemiological review of re- 4 emerging infectious disease, Clin Infect Dis, vol.49, issue.75015, pp.942-948, 2009.

S. Weaver, R. Winegar, I. Manger, and N. Forrester, Alphaviruses: Population genetics and determinants of emergence, Antiviral Research, vol.94, issue.3, pp.242-257, 2012.
DOI : 10.1016/j.antiviral.2012.04.002

S. Brighton, O. Prozesky, and A. De-la-harpe, Chikungunya virus infection. A retrospective 8 study of 107 cases, S Afr Med J, vol.63, pp.313-318, 1983.

C. Chastel, Human infections in Cambodia by the Chikungunya virus or a closely-related agent

D. Carey, R. Myers, C. Deranitz, M. Jadhav, and R. Reuben, The 1964 Chikungunya epidemic 12 at Vellore, South India, including observations on concurrent dengue, Trans R Soc Trop Med, vol.13

I. Schuffenecker, I. Iteman, and A. Michault, Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak, PLoS Medicine, vol.105, issue.7, p.263, 2006.
DOI : 10.1371/journal.pmed.0030263.st005

K. Tsetsarkin, D. Vanlandingham, M. Gee, C. Higgs, and S. , A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential, PLoS Pathogens, vol.1, issue.12, pp.201-219, 2007.
DOI : 10.1371/journal.ppat.0030201.st002

J. Miner, Y. Aw-yeang, and J. Fox, Brief Report: Chikungunya Viral Arthritis in the United States: A Mimic of Seronegative Rheumatoid Arthritis, Arthritis & Rheumatology, vol.120, issue.63, pp.1214-1220, 2015.
DOI : 10.1002/art.39027

T. Teo, Z. Her, and J. Tan, Carribbean and La Réunion Chikungunya virus isolates differ in 23 the capacity to induce pro-inflammatory Th1 and NK cell responses and acute joint pathology

P. Gérardin, V. Guernier, and J. Perrau, Estimating Chikungunya prevalence in La Réunion 26 Island outbreak by serosurveys: two methods for two critical times of the epidemic, BMC Infect, p.27

J. Lemant, V. Boisson, and A. Winer, Serious acute chikungunya virus infection requiring intensive care during the reunion island outbreak in 2005???2006*, Critical Care Medicine, vol.36, issue.9, pp.2536-2566, 2008.
DOI : 10.1097/CCM.0b013e318183f2d2

P. Gérardin, G. Barau, and A. Michault, Multidisciplinary Prospective Study of Mother-to-Child Chikungunya Virus Infections on the Island of La R??union, PLoS Medicine, vol.370, issue.3, p.60, 2008.
DOI : 10.1371/journal.pmed.0050060.sd001

G. Lebrun, K. Khadda, A. Reboux, O. Martinet, and B. Gaüzère, Guillain-Barr?? Syndrome after Chikungunya Infection, Emerging Infectious Diseases, vol.15, issue.3, pp.495-496, 2009.
DOI : 10.3201/eid1503.071482

URL : http://doi.org/10.3201/eid1503.071482

P. Gérardin, A. Fianu, and D. Malvy, Perceived morbidity and community burden after a 41 chikungunya outbreak: the TELECHIK survey, a population-based-cohort study, BMC Med, vol.42, issue.9, p.5, 2011.

A. Venkatesan, A. Tunkel, and K. Bloch, Case definitions, diagnostic algorithms, and 44 priorities in encephalitis: consensus statement of the International Encephalitis Consortium

A. Mailles and J. Stahl, Infectious Encephalitis in France in 2007: A National Prospective Study, Clinical Infectious Diseases, vol.49, issue.12, p.47
DOI : 10.1086/648419

URL : https://hal.archives-ouvertes.fr/hal-00515790

N. Vora, R. Holman, J. Mehal, C. Steiner, J. Blanton et al., Burden of encephalitis-associated hospitalizations in the United States, 1998-2010, Neurology, vol.82, issue.5, pp.443-451, 1998.
DOI : 10.1212/WNL.0000000000000086

T. Solomon, B. Michael, and P. Smith, Management of suspected viral encephalitis in adults

A. Mailles, V. Vaillant, and J. Stahl, Enc??phalites infectieuses: donn??es et??limites du??PMSI pour??l'??tude ??pid??miologique, France m??tropolitaine 2000???2002, M??decine et Maladies Infectieuses, vol.37, issue.2, pp.95-102, 2000.
DOI : 10.1016/j.medmal.2006.11.001

C. Reimann, E. Hayes, and C. Diguiseppi, Epidemiology of neuroinvasive arboviral disease 6 in the United States, 1999-2007, Am J Trop Med Hyg, vol.76, pp.974-979, 2008.

G. Campbell, S. Hills, and M. Fischer, Estimated global incidence of Japanese encephalitis:, Bulletin of the World Health Organization, vol.89, issue.10, pp.766-774, 2011.
DOI : 10.2471/BLT.10.085233

S. M. Rampal and H. Meena, Neurological complications in Chikungunya fever, J Assoc Physicians India, vol.10, issue.55, pp.765-769, 2007.

P. Lewthwaite, R. Vasanthapuram, and J. Osborne, Chikungunya Virus and Central Nervous System Infections in Children, India, Emerging Infectious Diseases, vol.15, issue.2, pp.329-331, 2009.
DOI : 10.3201/eid1502.080902

S. Chusri, P. Siripaitoon, S. Hirunpat, and K. Silpapojakul, Case Reports of Neuro-Chikungunya in Southern Thailand, American Journal of Tropical Medicine and Hygiene, vol.85, issue.2, pp.386-389, 2011.
DOI : 10.4269/ajtmh.2011.10-0725

C. Glaser, S. Honarmand, and L. Anderson, Beyond Viruses: Clinical Profiles and Etiologies Associated with Encephalitis, Clinical Infectious Diseases, vol.43, issue.12, pp.1565-1577, 2006.
DOI : 10.1086/509330

URL : http://cid.oxfordjournals.org/cgi/content/short/43/12/1565

J. Granerod, H. Ambrose, N. Davies, J. Clewley, A. Walsh et al., Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study, The Lancet Infectious Diseases, vol.10, issue.12, pp.835-844, 2010.
DOI : 10.1016/S1473-3099(10)70222-X

A. Mailles, D. Broucker, T. Costanzo, and P. , Long-term Outcome of Patients Presenting With Acute Infectious Encephalitis of Various Causes in France, Clinical Infectious Diseases, vol.54, issue.10, pp.1455-1464, 2012.
DOI : 10.1093/cid/cis226

URL : https://hal.archives-ouvertes.fr/hal-00875190

I. Steiner, P. Kennedy, and A. Pachner, The neurotropic herpes viruses: herpes simplex and varicella-zoster, The Lancet Neurology, vol.6, issue.11, pp.1015-1028, 2007.
DOI : 10.1016/S1474-4422(07)70267-3

J. Sejvar, The long-term outcomes of human West Nile virus infection, Clin Infect Dis, vol.44, pp.25-1617, 2007.

J. Gaensbauer, N. Lindsey, K. Messacar, J. Staples, and M. Fischer, Neuroinvasive Arboviral Disease in the United States: 2003 to 2012, PEDIATRICS, vol.134, issue.3, pp.642-650, 2014.
DOI : 10.1542/peds.2014-0498

T. Couderc, F. Chrétien, and C. Schilte, A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease, PLoS Pathogens, vol.41, issue.2, pp.30-59, 2008.
DOI : 10.1371/journal.ppat.0040029.sg003

URL : https://hal.archives-ouvertes.fr/pasteur-01402310

K. Labadie, T. Larcher, and C. Joubert, Chikungunya disease in nonhuman primates involves 32 long-term viral persistence in macrophages, J Clin Invest, vol.3, pp.894-906, 2010.

C. Fraisier, P. Koraka, and M. Belghazi, Kinetic Analysis of Mouse Brain Proteome Alterations Following Chikungunya Virus Infection before and after Appearance of Clinical Symptoms, PLoS ONE, vol.18, issue.3, p.91397, 2014.
DOI : 10.1371/journal.pone.0091397.s007

B. Adkins, S. Marshall-clarke, and C. Leclerc, Neonatal adaptive immunity comes of age, Nature Reviews Immunology, vol.20, issue.7, p.37
DOI : 10.1038/nri1394

M. Zacks and S. Paessler, Encephalitic alphaviruses, Veterinary Microbiology, vol.140, issue.3-4, pp.281-286, 2010.
DOI : 10.1016/j.vetmic.2009.08.023

P. Gérardin, S. Sampériz, and D. Ramful, Neurocognitive Outcome of Children Exposed to Perinatal Mother-to-Child Chikungunya Virus Infection: The CHIMERE Cohort Study on Reunion Island, PLoS Neglected Tropical Diseases, vol.209, issue.7, p.2996, 2014.
DOI : 10.1371/journal.pntd.0002996.s007