Chikungunya virus-associated encephalitis: a cohort study on La Réunion island, 2005-2009

Abstract : Objectives: To estimate the cumulative incidence rate (CIR) of Chikungunya virus (CHIKV)-associated Central Nervous System (CNS) disease during the La Réunion outbreak, and assess the disease burden and patient outcome after three years. Methods: CHIKV-associated CNS disease was characterized retrospectively in a cohort of patients with positive CHIKV RT-PCR or anti-CHIKV IgM antibodies in the cerebrospinal fluid and fulfilling International Encephalitis Consortium criteria for encephalitis or encephalopathy. Neurological sequelae were assessed after three years. Results: Between September 2005 and June 2006, 57 patients were diagnosed with CHIKV-associated CNS disease, including 24 with CHIKV-associated encephalitis, the latter corresponding to a CIR of 8.6 per 100,000 persons. Patients with encephalitis were observed at both extremes of age categories. CIR per 100,000 persons were 187 and 37 in patients below 1 year and over 65 years, respectively, both far superior to those of cumulated causes of encephalitis in the USA in these age categories. The case fatality rate of CHIKV-associated encephalitis was 16.6% and the proportion of children discharged with persistent disabilities estimated between 30% and 45%. Beyond the neonatal period, the clinical presentation and outcomes were less severe in infants than in adults. Conclusions: In the context of a large outbreak, CHIKV is a significant cause of CNS disease. As with other etiologies, CHIKV-associated encephalitis case distribution by age follows a U-shaped parabolic curve.
Type de document :
Article dans une revue
Neurology, American Academy of Neurology, 2015
Liste complète des métadonnées

Littérature citée [50 références]  Voir  Masquer  Télécharger

https://hal-pasteur.archives-ouvertes.fr/pasteur-01204797
Contributeur : Therese Couderc <>
Soumis le : jeudi 24 septembre 2015 - 15:32:52
Dernière modification le : lundi 6 mars 2017 - 01:04:28
Document(s) archivé(s) le : mercredi 26 avril 2017 - 18:39:53

Fichiers

CHIKV encephalitis_Neurology-R...
Fichiers produits par l'(les) auteur(s)

  •  Gérardin P et al, Neurology 2016 (1).pdf    Visible le : jamais  Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

  • HAL Id : pasteur-01204797, version 1
  • PUBMED : 26609145

Collections

Citation

Patrick Gérardin, Thérèse Couderc, Marc Bintner, Patrick Tournebize, Michel Renouil, et al.. Chikungunya virus-associated encephalitis: a cohort study on La Réunion island, 2005-2009 . Neurology, American Academy of Neurology, 2015. 〈pasteur-01204797〉

Partager

Métriques

Consultations de
la notice

225

Téléchargements du document

153