Assessing the epidemiological effect of wolbachia for dengue control.

Louis Lambrechts (1) , Neil M Ferguson (2) , Eva Harris (3) , Edward C Holmes (4) , Elizabeth A Mcgraw (5) , Scott L O'Neill (5) , Eng E Ooi (6) , Scott A Ritchie (7) , Peter A Ryan (5) , Thomas W Scott (8, 9) , Cameron P Simmons (10, 11, 12) , Scott C Weaver (13)

1 IVI - Interactions Virus-Insectes
2 MRC Centre for Outbreak Analysis and Modelling [London]
3 Division of Infectious Diseases and Vaccinology
4 Marie Bashir Institute for Infectious Diseases and Biosecurity
5 School of Biological Sciences [Clayton]
6 Duke-National University of Singapore Graduate Medical School
7 School of Public Health and Tropical Medicine and Rehabilitative Sciences
8 Fogarty International Center
9 Department of Entomology and Nematology
10 Nuffield Department of Clinical Medicine [Oxford]
11 Centre for Tropical Medicine
12 Nossal Institute of Global Health
13 Institute for Human Infections and Immunity and Department of Pathology

Dengue viruses cause more human morbidity and mortality than any other arthropod-borne virus. Dengue prevention relies mainly on vector control; however, the failure of traditional methods has promoted the development of novel entomological approaches. Although use of the intracellular bacterium wolbachia to control mosquito populations was proposed 50 years ago, only in the past decade has its use as a potential agent of dengue control gained substantial interest. Here, we review evidence that supports a practical approach for dengue reduction through field release of wolbachia-infected mosquitoes and discuss the additional studies that have to be done before the strategy can be validated and implemented. A crucial next step is to assess the efficacy of wolbachia in reducing dengue virus transmission. We argue that a cluster randomised trial is at this time premature because choice of wolbachia strain for release and deployment strategies are still being optimised. We therefore present a pragmatic approach to acquiring preliminary evidence of efficacy through various complementary methods including a prospective cohort study, a geographical cluster investigation, virus phylogenetic analysis, virus surveillance in mosquitoes, and vector competence assays. This multipronged approach could provide valuable intermediate evidence of efficacy to justify a future cluster randomised trial.

Domains: Life Sciences [q-bio]; Santé publique et épidémiologie; Life Sciences [q-bio]; Ecology, environment; Symbiosis; Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Human health and pathology; Emerging diseases

Louis Lambrechts, Neil M Ferguson, Eva Harris, Edward C Holmes, Elizabeth A Mcgraw, et al.. Assessing the epidemiological effect of wolbachia for dengue control.. The Lancet Infectious Diseases, 2015, 15 (7), pp.862-6. ⟨10.1016/S1473-3099(15)00091-2⟩. ⟨pasteur-01176423⟩