Phosphoinositides and host-pathogen interactions.

Javier Pizarro-Cerdá (1) , Andreas Kühbacher (2) , Pascale Cossart (1)

1 UIBC - Interactions Bactéries-Cellules
2 Department of Molecular Biotechnology

Phosphoinositides control key cellular processes including vesicular trafficking and actin polymerization. Intracellular bacterial pathogens manipulate phosphoinositide metabolism in order to promote their uptake by target cells and to direct in some cases the biogenesis of their replication compartments. In this chapter, we review the molecular strategies that major pathogens including Listeria, Mycobacterium, Shigella, Salmonella, Legionella and Yersinia use to hijack phosphoinositides during infection. This article is part of a Special Issue entitled Phosphoinositides.

Keywords: Cytoskeleton; Legionella; Listeria; Mycobacteria; Salmonella; Shigella; Yersinia

Domains: Life Sciences [q-bio]; Cellular Biology

Javier Pizarro-Cerdá, Andreas Kühbacher, Pascale Cossart. Phosphoinositides and host-pathogen interactions.. BBA - Biochimica et Biophysica Acta, 2015, 1851 (6), pp.911-918. ⟨10.1016/j.bbalip.2014.09.011⟩. ⟨pasteur-01162068⟩