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(. Casanova, Canceropole Ile de France the " Fondation ARC pour la Recherche sur le Cancer " (SFI20121205641) and the " Ligue Contre le Cancer The authors declare no competing financial interests, NIH (5R01AI100887), the Manton Foundation (L.D. Notarangelo), the Dubai Harvard Foundation for Medical Research (W. Al-Herz and L.D. Notarangelo), and the Kuwait Foundation for the Advancement of Sciences, 1302.

:. B. Author-contributions, E. Boisson, K. Laplantine, N. Dobbs, E. Tarantino et al., Hopkins performed the experiments Notarangelo took care of the patient. A. Cobat, A. Belkadi, Y. Itan, and L. Abel performed and analyzed the SNP arrays, supervised and analyzed the histology. B. Boisson, E. Laplantine, and S.-Y. Pai supervised experiments. L.D. Notarangelo identified and took care of the patient, and also planned and supervised experiments. E. Laplantine, J.-L. Casanova, A. Israel, and L.D. Notarangelo contributed to the writing of the manuscript. B. Boisson coordinated the study and wrote the manuscript. All authors discussed the results and commented on the manuscript

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