L. Ivashkiv and L. Donlin, Regulation of type I interferon responses, Nature Reviews Immunology, vol.7, issue.1, pp.36-49, 2014.
DOI : 10.1038/nri3581

W. Schneider, M. Chevillotte, and C. Rice, Interferon-Stimulated Genes: A Complex Web of Host Defenses, Annual Review of Immunology, vol.32, issue.1, pp.513-545, 2014.
DOI : 10.1146/annurev-immunol-032713-120231

J. Wu and Z. Chen, Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids, Annual Review of Immunology, vol.32, issue.1, pp.461-488, 2014.
DOI : 10.1146/annurev-immunol-032713-120156

Y. Chiu, J. Macmillan, and Z. Chen, RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway, Cell, vol.138, issue.3, pp.576-591, 2009.
DOI : 10.1016/j.cell.2009.06.015

S. Myong, S. Cui, P. Cornish, A. Kirchhofer, and M. Gack, Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate-Dependent Translocase on Double-Stranded RNA, Science, vol.323, issue.5917, pp.1070-1074, 2009.
DOI : 10.1126/science.1168352

T. Koshiba, Mitochondrial-mediated antiviral immunity, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1833, issue.1, pp.225-232, 2013.
DOI : 10.1016/j.bbamcr.2012.03.005

J. Jacobs and C. Coyne, Mechanisms of MAVS Regulation at the Mitochondrial Membrane, Journal of Molecular Biology, vol.425, issue.24, pp.5009-5019, 2013.
DOI : 10.1016/j.jmb.2013.10.007

J. Hiscott, Convergence of the NF-??B and IRF pathways in the regulation of the innate antiviral response, Cytokine & Growth Factor Reviews, vol.18, issue.5-6, pp.483-490, 2007.
DOI : 10.1016/j.cytogfr.2007.06.002

P. Genin, A. Vaccaro, and A. Civas, The role of differential expression of human interferon-A genes in antiviral immunity, Cytokine & Growth Factor Reviews, vol.20, issue.4, pp.283-295, 2009.
DOI : 10.1016/j.cytogfr.2009.07.005
URL : https://hal.archives-ouvertes.fr/hal-00412298

W. Chen, W. Royer, and . Jr, Structural insights into interferon regulatory factor activation, Cellular Signalling, vol.22, issue.6, pp.883-887, 2010.
DOI : 10.1016/j.cellsig.2009.12.005

E. Helgason, Q. Phung, and E. Dueber, Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1, FEBS Letters, vol.201, issue.8, pp.1230-1237, 2013.
DOI : 10.1016/j.febslet.2013.01.059

S. Li, L. Wang, M. Berman, Y. Kong, and M. Dorf, Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production, Immunity, vol.35, issue.3, pp.426-440, 2011.
DOI : 10.1016/j.immuni.2011.06.014

J. Korac, V. Schaeffer, I. Kovacevic, A. Clement, and B. Jungblut, Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates, Journal of Cell Science, vol.126, issue.2, pp.580-592, 2013.
DOI : 10.1242/jcs.114926

P. Wild, H. Farhan, D. Mcewan, S. Wagner, and V. Rogov, Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth, Science, vol.333, issue.6039, pp.228-233, 2011.
DOI : 10.1126/science.1205405

F. Ikeda, C. Hecker, A. Rozenknop, R. Nordmeier, and V. Rogov, Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes, The EMBO Journal, vol.5, issue.14, pp.3451-3462, 2007.
DOI : 10.1038/sj.emboj.7601773

L. Wang, S. Li, and M. Dorf, NEMO Binds Ubiquitinated TANK-Binding Kinase 1 (TBK1) to Regulate Innate Immune Responses to RNA Viruses, PLoS ONE, vol.7, issue.9, p.23028469, 2012.
DOI : 10.1371/journal.pone.0043756.g006

K. Clark, O. Takeuchi, S. Akira, and P. Cohen, The TRAF-associated protein TANK facilitates cross-talk within the I??B kinase family during Toll-like receptor signaling, Proceedings of the National Academy of Sciences, vol.108, issue.41, pp.17093-17098, 2011.
DOI : 10.1073/pnas.1114194108

C. Lei, B. Zhong, Y. Zhang, J. Zhang, and S. Wang, Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1, Immunity, vol.33, p.21145761, 2010.

J. Gabhann, R. Higgs, K. Brennan, W. Thomas, and J. Damen, Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-?? Production, The Journal of Immunology, vol.184, issue.5, pp.2314-2320, 2010.
DOI : 10.4049/jimmunol.0902589

Y. Zhao, L. Liang, Y. Fan, S. Sun, and L. An, PPM1B negatively regulates antiviral response via dephosphorylating TBK1, Cellular Signalling, vol.24, issue.11, pp.2197-2204, 2012.
DOI : 10.1016/j.cellsig.2012.06.017

C. Wang, T. Chen, J. Zhang, M. Yang, and N. Li, The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon, Nature Immunology, vol.342, issue.7, pp.744-752, 2009.
DOI : 10.1038/ni.1742

C. Friedman, O. Donnell, M. Legarda-addison, D. Ng, A. Cardenas et al., The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response, EMBO reports, vol.175, issue.9, pp.930-936, 2008.
DOI : 10.1038/ni1465

M. Zhang, X. Wu, A. Lee, J. W. Chang, and M. , Regulation of I??B Kinase-related Kinases and Antiviral Responses by Tumor Suppressor CYLD, Journal of Biological Chemistry, vol.283, issue.27, pp.18621-18626, 2008.
DOI : 10.1074/jbc.M801451200

K. Parvatiyar, G. Barber, and E. Harhaj, TAX1BP1 and A20 Inhibit Antiviral Signaling by Targeting TBK1-IKKi Kinases, Journal of Biological Chemistry, vol.285, issue.20, pp.14999-15009, 2010.
DOI : 10.1074/jbc.M110.109819

L. Zhang, X. Zhao, M. Zhang, W. Zhao, and C. Gao, Ubiquitin-Specific Protease 2b Negatively Regulates IFN-?? Production and Antiviral Activity by Targeting TANK-Binding Kinase 1, The Journal of Immunology, vol.193, issue.5, pp.2230-2237, 2014.
DOI : 10.4049/jimmunol.1302634

S. Charoenthongtrakul, L. Gao, K. Parvatiyar, D. Lee, and E. Harhaj, RING Finger Protein 11 Targets TBK1/IKKi Kinases to Inhibit Antiviral Signaling, PLoS ONE, vol.362, issue.1, p.23308279, 2013.
DOI : 10.1371/journal.pone.0053717.s003

S. Belgnaoui, S. Paz, S. Samuel, M. Goulet, and Q. Sun, Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex, Cell Host & Microbe, vol.12, issue.2, pp.211-222, 2012.
DOI : 10.1016/j.chom.2012.06.009

Y. Li, J. Kang, and M. Horwitz, Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains, Molecular and Cellular Biology, vol.18, issue.3, pp.1601-1610, 1998.
DOI : 10.1128/MCB.18.3.1601

K. Schwamborn, R. Weil, G. Courtois, S. Whiteside, and A. Israel, Phorbol Esters and Cytokines Regulate the Expression of theNEMO-related Protein, a Molecule Involved in a NF-??B-independent Pathway, Journal of Biological Chemistry, vol.275, issue.30, pp.22780-22789, 2000.
DOI : 10.1074/jbc.M001500200

I. Munitic, G. Torchia, M. Meena, N. Zhu, G. Li et al., Optineurin Insufficiency Impairs IRF3 but Not NF-??B Activation in Immune Cells, The Journal of Immunology, vol.191, issue.12, pp.6231-6240, 2013.
DOI : 10.4049/jimmunol.1301696

C. Journo, F. J. About, F. Chevalier, S. Afonso, and P. , NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein, PLoS Pathogens, vol.5, 2009.
URL : https://hal.archives-ouvertes.fr/pasteur-00455158

H. Ying and B. Yue, Cellular and Molecular Biology of Optineurin, Int Rev Cell Mol Biol, vol.294, pp.223-258, 2012.
DOI : 10.1016/B978-0-12-394305-7.00005-7

D. Kachaner, P. Genin, E. Laplantine, and R. Weil, Toward an integrative view of Optineurin functions, Cell Cycle, vol.15, issue.15, p.22801549, 2012.
DOI : 10.4161/cc.20946

S. Morton, L. Hesson, P. M. Cohen, and P. , Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma, FEBS Letters, vol.22, issue.6, pp.997-1002, 2008.
DOI : 10.1016/j.febslet.2008.02.047

C. Gleason, A. Ordureau, R. Gourlay, J. Arthur, and P. Cohen, Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon ??, Journal of Biological Chemistry, vol.286, issue.41, pp.35663-35674, 2011.
DOI : 10.1074/jbc.M111.267567

J. Mankouri, R. Fragkoudis, K. Richards, L. Wetherill, and M. Harris, Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection, PLoS Pathogens, vol.6, p.20174559, 2010.

T. Sakaguchi, T. Irie, R. Kawabata, A. Yoshida, and H. Maruyama, Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation, Neuroscience Letters, vol.505, issue.3, pp.279-281, 2011.
DOI : 10.1016/j.neulet.2011.10.040

D. Kachaner, F. J. Laplantine, E. Bauch, A. Bennett, and K. , Plk1-Dependent Phosphorylation of Optineurin Provides a Negative Feedback Mechanism for Mitotic Progression, Molecular Cell, vol.45, issue.4, pp.553-566, 2012.
DOI : 10.1016/j.molcel.2011.12.030

Y. Wu, H. Tan, G. Shui, C. Bauvy, and Q. Huang, Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase, Journal of Biological Chemistry, vol.285, issue.14, pp.10850-10861, 2010.
DOI : 10.1074/jbc.M109.080796

D. Tu, Z. Zhu, A. Zhou, C. Yun, and K. Lee, Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1, Cell Reports, vol.3, issue.3, pp.747-758, 2013.
DOI : 10.1016/j.celrep.2013.01.033

S. Sun, CYLD: a tumor suppressor deubiquitinase regulating NF-??B activation and diverse biological processes, Cell Death and Differentiation, vol.25, issue.1, pp.25-34, 2010.
DOI : 10.1038/cdd.2009.43

J. Niu, Y. Shi, K. Iwai, and Z. Wu, LUBAC regulates NF-??B activation upon genotoxic stress by promoting linear ubiquitination of NEMO, The EMBO Journal, vol.31, issue.18, pp.3741-3753, 2011.
DOI : 10.1038/emboj.2011.264

M. Chalasani, G. Swarup, and D. Balasubramanian, Optineurin and Its Mutants: Molecules Associated with Some Forms of Glaucoma, Ophthalmic Research, vol.42, issue.4, pp.176-184, 2009.
DOI : 10.1159/000232400

N. Shembade and E. Harhaj, Regulation of NF-??B signaling by the A20 deubiquitinase, Cellular and Molecular Immunology, vol.12, issue.2, pp.123-130, 2012.
DOI : 10.1038/cmi.2011.59

A. Kovalenko, C. Chable-bessia, G. Cantarella, A. Israel, and D. Wallach, The tumour suppressor CYLD negatively regulates NF-??B signalling by deubiquitination, Nature, vol.424, issue.6950, pp.801-805, 2003.
DOI : 10.1038/nature01802

A. Nagabhushana, M. Bansal, and G. Swarup, Optineurin is required for CYLD-dependent inhibition of TNFalpha-induced NF-kappaB activation, PloS one, vol.6, p.21408173, 2011.

J. Kim, E. Welsh, U. Oguz, B. Fang, and Y. Bai, Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells, Proceedings of the National Academy of Sciences, vol.110, issue.30, pp.12414-12419, 2013.
DOI : 10.1073/pnas.1220674110

W. Van-zuylen, P. Doyon, J. Clement, K. Khan, D. Ambrosio et al., Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity, PLoS Pathogens, vol.108, issue.7, p.22792062, 2012.
DOI : 10.1371/journal.ppat.1002747.s007

J. Kagan, Signaling Organelles of the Innate Immune System, Cell, vol.151, issue.6, pp.1168-1178, 2012.
DOI : 10.1016/j.cell.2012.11.011

T. Suzuki, H. Oshiumi, M. Miyashita, H. Aly, and M. Matsumoto, Cell Type-Specific Subcellular Localization of Phospho-TBK1 in Response to Cytoplasmic Viral DNA, PLoS ONE, vol.8, issue.12, p.24349538, 2013.
DOI : 10.1371/journal.pone.0083639.s003

A. West, G. Shadel, and S. Ghosh, Mitochondria in innate immune responses, Nature Reviews Immunology, vol.278, issue.6, pp.389-402, 2011.
DOI : 10.1038/nri2975

K. Eisenacher and A. Krug, Regulation of RLR-mediated innate immune signaling ??? It is all about keeping the balance, European Journal of Cell Biology, vol.91, issue.1, pp.36-47, 2012.
DOI : 10.1016/j.ejcb.2011.01.011

D. Goubau, S. Deddouche, R. Sousa, and C. , Cytosolic Sensing of Viruses, Immunity, vol.38, issue.5, pp.855-869, 2013.
DOI : 10.1016/j.immuni.2013.05.007

W. Zhao, Negative regulation of TBK1-mediated antiviral immunity, FEBS Letters, vol.51, issue.6, pp.542-548, 2013.
DOI : 10.1016/j.febslet.2013.01.052

D. Kachaner, E. Laplantine, P. Genin, and R. Weil, Optineurin, Cell Cycle, vol.10, issue.8, p.22487679, 2012.
DOI : 10.1126/science.1205405
URL : https://hal.archives-ouvertes.fr/tel-00831584

D. Vitour, S. Dabo, A. Pour, M. Vilasco, M. Vidalain et al., Polo-like Kinase 1 (PLK1) Regulates Interferon (IFN) Induction by MAVS, Journal of Biological Chemistry, vol.284, issue.33, pp.21797-21809, 2009.
DOI : 10.1074/jbc.M109.018275

X. Liu, W. Chen, B. Wei, Y. Shan, and C. Wang, IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1, The Journal of Immunology, vol.187, issue.5, pp.2559-2568, 2011.
DOI : 10.4049/jimmunol.1100963

D. Gough, N. Messina, C. Clarke, R. Johnstone, and D. Levy, Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling, Immunity, vol.36, issue.2, pp.166-174, 2012.
DOI : 10.1016/j.immuni.2012.01.011

M. Essers, S. Offner, W. Blanco-bose, Z. Waibler, and U. Kalinke, IFN?? activates dormant haematopoietic stem cells in vivo, Nature, vol.6, issue.7240, pp.904-908, 2009.
DOI : 10.1038/nature07815

T. Sato, N. Onai, H. Yoshihara, F. Arai, and T. Suda, Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon???dependent exhaustion, Nature Medicine, vol.1106, issue.6, pp.696-700, 1973.
DOI : 10.1038/nm.1973

H. Takayanagi, S. Kim, K. Matsuo, H. Suzuki, and T. Suzuki, RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-??, Nature, vol.416, issue.6882, pp.744-749, 2002.
DOI : 10.1038/416744a

N. Hata, M. Sato, A. Takaoka, M. Asagiri, and N. Tanaka, Constitutive IFN-??/?? Signal for Efficient IFN-??/?? Gene Induction by Virus, Biochemical and Biophysical Research Communications, vol.285, issue.2, pp.518-525, 2001.
DOI : 10.1006/bbrc.2001.5159

Y. Kwon, Y. Choe, and H. Chin, Development of glaucoma in the course of interferon Alpha therapy for chronic hepatitis B, Yonsei Medical Journal, vol.42, issue.1, pp.134-136, 2001.
DOI : 10.3349/ymj.2001.42.1.134

Q. Meng, J. Lv, H. Ge, L. Zhang, and F. Xue, Overexpressed mutant optineurin(E50K) induces retinal ganglion cells apoptosis via the mitochondrial pathway, Molecular Biology Reports, vol.14, issue.5, pp.5867-5873, 2012.
DOI : 10.1007/s11033-011-1397-7

Q. Meng, Z. Xiao, H. Yuan, F. Xue, and Y. Zhu, Transgenic mice with overexpression of mutated human optineurin(E50K) in the retina, Molecular Biology Reports, vol.16, issue.2, pp.1119-1124, 2012.
DOI : 10.1007/s11033-011-0840-0

X. Shen, H. Ying, Y. Qiu, J. Park, and R. Shyam, Processing of Optineurin in Neuronal Cells, Journal of Biological Chemistry, vol.286, issue.5, pp.3618-3629, 2011.
DOI : 10.1074/jbc.M110.175810

E. Cirulli, B. Lasseigne, S. Petrovski, P. Sapp, and P. Dion, Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways, Science, vol.347, issue.6229, pp.1436-1441, 2015.
DOI : 10.1126/science.aaa3650

A. Freischmidt, T. Wieland, B. Richter, W. Ruf, and V. Schaeffer, Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia, Nature Neuroscience, vol.18, issue.5, p.4000, 2015.
DOI : 10.1016/j.celrep.2013.01.034

G. Uze, D. Marco, S. Mouchel-vielh, E. Monneron, D. Bandu et al., Domains of Interaction between Alpha Interferon and its Receptor Components, Journal of Molecular Biology, vol.243, issue.2, pp.245-257, 1994.
DOI : 10.1006/jmbi.1994.1651

J. Moretti, P. Chastagner, C. Liang, M. Cohn, and A. Israel, The Ubiquitin-specific Protease 12 (USP12) Is a Negative Regulator of Notch Signaling Acting on Notch Receptor Trafficking toward Degradation, Journal of Biological Chemistry, vol.287, issue.35, pp.29429-29441, 2012.
DOI : 10.1074/jbc.M112.366807

N. Tarantino, J. Tinevez, E. Crowell, B. Boisson, and R. Henriques, TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO???IKK supramolecular structures, The Journal of Cell Biology, vol.19, issue.2, pp.231-245, 2014.
DOI : 10.1016/S1074-7613(00)80183-1