T. Beveridge, Structures of gram-negative cell walls and their derived membrane vesicles, J. Bacteriol, vol.181, pp.4725-4733, 1999.

K. Bonnington and M. Kuehn, Protein selection and export via outer membrane vesicles, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1843, issue.8, pp.1612-1619, 2014.
DOI : 10.1016/j.bbamcr.2013.12.011

URL : http://doi.org/10.1016/j.bbamcr.2013.12.011

C. Schwechheimer, C. Sullivan, and M. Kuehn, Envelope Control of Outer Membrane Vesicle Production in Gram-Negative Bacteria, Biochemistry, vol.52, issue.18, pp.3031-3040, 2013.
DOI : 10.1021/bi400164t

A. Horstman and M. Kuehn, Enterotoxigenic Escherichia coli Secretes Active Heat-labile Enterotoxin via Outer Membrane Vesicles, Journal of Biological Chemistry, vol.275, issue.17, pp.12489-12496, 2000.
DOI : 10.1074/jbc.275.17.12489

S. Kato, Y. Kowashi, and D. Demuth, Outer membrane-like vesicles secreted by Actinobacillus actinomycetemcomitans are enriched in leukotoxin, Microbial Pathogenesis, vol.32, issue.1, pp.1-13, 2002.
DOI : 10.1006/mpat.2001.0474

J. Wensink and B. Witholt, Outer-Membrane Vesicles Released by Normally Growing Escherichia coli Contain Very Little Lipoprotein, European Journal of Biochemistry, vol.63, issue.2, pp.331-335, 1981.
DOI : 10.1016/0014-5793(75)80272-9

P. Brandtzaeg, K. Bryn, P. Kierulf, R. Ovstebo, E. Namork et al., Meningococcal endotoxin in lethal septic shock plasma studied by gas chromatography, mass-spectrometry, ultracentrifugation, and electron microscopy., Journal of Clinical Investigation, vol.89, issue.3, pp.816-823, 1992.
DOI : 10.1172/JCI115660

S. Hynes, J. Keenan, J. Ferris, H. Annuk, and A. Moran, Lewis Epitopes on Outer Membrane Vesicles of Relevance to Helicobacter pylori Pathogenesis, Helicobacter, vol.2, issue.2, pp.146-156, 2005.
DOI : 10.1073/pnas.96.15.8359

Z. Li, A. Clarke, and T. Beveridge, Gram-negative bacteria produce membrane vesicles which are capable of killing other bacteria, J. Bacteriol, vol.180, pp.5478-5483, 1998.

A. Mcbroom and M. Kuehn, Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response, Molecular Microbiology, vol.117, issue.2, pp.545-558, 2007.
DOI : 10.1111/j.1365-2958.2006.05522.x

S. Wai, B. Lindmark, T. Soderblom, A. Takade, M. Westermark et al., Vesicle-Mediated Export and Assembly of Pore-Forming Oligomers of the Enterobacterial ClyA Cytotoxin, Cell, vol.115, issue.1, pp.25-35, 2003.
DOI : 10.1016/S0092-8674(03)00754-2

H. Yoon, C. Ansong, J. Adkins, and F. Heffron, Discovery of Salmonella Virulence Factors Translocated via Outer Membrane Vesicles to Murine Macrophages, Infection and Immunity, vol.79, issue.6, pp.2182-2192, 2011.
DOI : 10.1128/IAI.01277-10

R. Alaniz, B. Deatherage, J. Lara, and B. Cookson, Membrane Vesicles Are Immunogenic Facsimiles of Salmonella typhimurium That Potently Activate Dendritic Cells, Prime B and T Cell Responses, and Stimulate Protective Immunity In Vivo, The Journal of Immunology, vol.179, issue.11, pp.7692-7701, 2007.
DOI : 10.4049/jimmunol.179.11.7692

A. Bernadac, M. Gavioli, J. Lazzaroni, R. S. Lloubes, and R. , Escherichia coli tol-pal mutants form outer membrane vesicles, J. Bacteriol, vol.180, pp.4872-4878, 1998.

H. Chutkan, I. Macdonald, A. Manning, and M. Kuehn, Quantitative and Qualitative Preparations of Bacterial Outer Membrane Vesicles, Methods Mol. Biol, vol.966, pp.259-272978, 2013.
DOI : 10.1007/978-1-62703-245-2_16

M. Gaillard, D. Bottero, A. Errea, M. Ormazabal, M. Zurita et al., Acellular pertussis vaccine based on outer membrane vesicles capable of conferring both long-lasting immunity and protection against different strain genotypes, Vaccine, vol.32, issue.8, pp.931-937, 2014.
DOI : 10.1016/j.vaccine.2013.12.048

W. Zollinger, M. Donets, D. Schmiel, V. Pinto, J. Labrie et al., Design and evaluation in mice of a broadly protective meningococcal group B native outer membrane vesicle vaccine, Vaccine, vol.28, issue.31, pp.5057-5067, 2010.
DOI : 10.1016/j.vaccine.2010.05.006

D. Granoff, Review of Meningococcal Group B Vaccines, Clinical Infectious Diseases, vol.50, issue.s2, pp.54-65, 2010.
DOI : 10.1086/648966

N. Kesty and M. Kuehn, Incorporation of Heterologous Outer Membrane and Periplasmic Proteins into Escherichia coli Outer Membrane Vesicles, Journal of Biological Chemistry, vol.279, issue.3, pp.2069-2076, 2004.
DOI : 10.1074/jbc.M307628200

M. Muralinath, M. Kuehn, K. Roland, R. Curtiss, and I. , Immunization with Salmonella enterica Serovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge with Streptococcus pneumoniae, Infection and Immunity, vol.79, issue.2, pp.887-894, 2011.
DOI : 10.1128/IAI.00950-10

J. Kim, A. Doody, D. Chen, G. Cremona, M. Shuler et al., Engineered Bacterial Outer Membrane Vesicles with Enhanced Functionality, Journal of Molecular Biology, vol.380, issue.1, pp.51-66, 2008.
DOI : 10.1016/j.jmb.2008.03.076

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617544

J. Schroeder and T. Aebischer, Recombinant outer membrane vesicles to augment antigen-specific live vaccine responses, Vaccine, vol.27, issue.48, pp.6748-6754, 2009.
DOI : 10.1016/j.vaccine.2009.08.106

S. Barat, Y. Willer, K. Rizos, B. Claudi, A. Maze et al., Immunity to Intracellular Salmonella Depends on Surface-associated Antigens, PLoS Pathogens, vol.8, issue.10, 2012.
DOI : 10.1371/journal.ppat.1002966.s003

J. Hess, I. Gentschev, D. Miko, M. Welzel, C. Ladel et al., Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis., Proceedings of the National Academy of Sciences, vol.93, issue.4, 1996.
DOI : 10.1073/pnas.93.4.1458

H. Kang, R. Curtiss, and I. , vaccines following oral immunization, FEMS Immunology & Medical Microbiology, vol.37, issue.2-3, pp.99-104, 2003.
DOI : 10.1016/S0928-8244(03)00063-4

W. Jong, Z. Soprova, K. De-punder, C. Ten-hagen-jongman, S. Wagner et al., A structurally informed autotransporter platform for efficient heterologous protein secretion and display, Microbial Cell Factories, vol.11, issue.1, 2012.
DOI : 10.1016/j.febslet.2009.12.057

P. Van-ulsen, S. Rahman, W. Jong, M. Daleke-schermerhorn, and J. Luirink, Type V secretion: From biogenesis to biotechnology, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1843, issue.8, pp.1592-1611, 2014.
DOI : 10.1016/j.bbamcr.2013.11.006

W. Jong, A. Sauri, and J. Luirink, Extracellular production of recombinant proteins using bacterial autotransporters, Current Opinion in Biotechnology, vol.21, issue.5, pp.646-652, 2010.
DOI : 10.1016/j.copbio.2010.07.009

J. Jose and T. Meyer, The Autodisplay Story, from Discovery to Biotechnical and Biomedical Applications, Microbiology and Molecular Biology Reviews, vol.71, issue.4, pp.600-61900011, 2007.
DOI : 10.1128/MMBR.00011-07

M. Lum and R. Morona, IcsA autotransporter passenger promotes increased fusion protein expression on the cell surface, Microbial Cell Factories, vol.11, issue.1, 2012.
DOI : 10.1046/j.1365-2958.1997.2541625.x

T. Nicolay, L. Lemoine, E. Lievens, S. Balzarini, J. Vanderleyden et al., Probing the applicability of autotransporter based surface display with the EstA autotransporter of Pseudomonas stutzeri A15, Microbial Cell Factories, vol.11, issue.1, 2012.
DOI : 10.1128/AEM.01369-08

B. Otto, R. Sijbrandi, J. Luirink, B. Oudega, J. Heddle et al., Crystal Structure of Hemoglobin Protease, a Heme Binding Autotransporter Protein from Pathogenic Escherichia coli, Journal of Biological Chemistry, vol.280, issue.17, pp.17339-17345, 2005.
DOI : 10.1074/jbc.M412885200

N. Dautin, T. Barnard, D. Anderson, and H. Bernstein, Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism, The EMBO Journal, vol.269, issue.7, pp.1942-1952, 2007.
DOI : 10.1038/sj.emboj.7601638

W. Jong, C. Ten-hagen-jongman, T. Den-blaauwen, D. Slotboom, J. Tame et al., Limited tolerance towards folded elements during secretion of the autotransporter Hbp, Molecular Microbiology, vol.179, issue.5, pp.1524-1536, 2007.
DOI : 10.1038/nsb0995-758

R. Derouiche, H. Benedetti, J. Lazzaroni, C. Lazdunski, and R. Lloubes, Protein complex within Escherichia coli inner membrane. TolA N-terminal domain interacts with TolQ and TolR proteins, Journal of Biological Chemistry, vol.270, issue.19, pp.11078-11084, 1995.
DOI : 10.1074/jbc.270.19.11078

S. Hoiseth and B. Stocker, Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines, Nature, vol.58, issue.5812, pp.238-239, 1981.
DOI : 10.1038/291238a0

L. Hashemzadeh-bonehi, F. Mehraein-ghomi, C. Mitsopoulos, J. Jacob, E. Hennessey et al., Importance of using lac rather than ara promoter vectors for modulating the levels of toxic gene products in Escherichia coli, Molecular Microbiology, vol.30, issue.3, pp.676-678, 1998.
DOI : 10.1046/j.1365-2958.1998.01116.x

K. Datsenko and B. Wanner, One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products, Proceedings of the National Academy of Sciences, vol.97, issue.12, pp.6640-6645, 2000.
DOI : 10.1073/pnas.120163297

T. Baba and H. Mori, The Construction of Systematic In-Frame, Single-Gene Knockout Mutant Collection in Escherichia coli K-12, Methods Mol. Biol, vol.416, pp.171-181978, 2008.
DOI : 10.1007/978-1-59745-321-9_11

J. Klausen, M. Magnusson, A. Andersen, and C. Koch, Characterization of Purified Protein Derivative of Tuberculin by use of Monoclonal Antibodies: Isolation of a Delayed-Type Hypersensitivity Reactive Component from M. tuberculosis Culture Filtrate, Scandinavian Journal of Immunology, vol.22, issue.3, pp.345-349, 1994.
DOI : 10.1006/abio.1976.9999

A. Drowart, J. De-bruyn, K. Huygen, G. Damiani, H. Godfrey et al., Isoelectrophoretic Characterization of Protein Antigens Present in Mycobacterial Culture Filtrates and Recognized by Monoclonal Antibodies Directed Against the Mycobacterium bovis BCG Antigen 85 Complex, Scandinavian Journal of Immunology, vol.58, issue.7, pp.697-702, 1992.
DOI : 10.1016/0022-1759(91)90330-I

B. Otto, S. Van-dooren, C. Dozois, J. Luirink, and B. Oudega, Escherichia coli Hemoglobin Protease Autotransporter Contributes to Synergistic Abscess Formation and Heme-Dependent Growth of Bacteroides fragilis, Infection and Immunity, vol.70, issue.1, pp.5-10, 2002.
DOI : 10.1128/IAI.70.1.5-10.2002

S. Van-dooren, J. Tame, J. Luirink, B. Oudega, and B. Otto, Purification of the autotransporter protein Hbp of Escherichia coli, FEMS Microbiology Letters, vol.205, issue.1, pp.147-150, 2001.
DOI : 10.1016/S0378-1097(01)00454-2

G. Cajo, B. Horne, W. Kelley, F. Schwager, C. Georgopoulos et al., The Role of the DIF Motif of the DnaJ (Hsp40) Co-chaperone in the Regulation of the DnaK (Hsp70) Chaperone Cycle, Journal of Biological Chemistry, vol.281, issue.18, pp.12436-12444, 2006.
DOI : 10.1074/jbc.M511192200

R. Chen and U. Henning, Aperiplasmic protein (Skp) of Escherichia coli selectively binds a class of outer membrane proteins, Molecular Microbiology, vol.222, issue.6, pp.1287-1294, 1996.
DOI : 10.1073/pnas.80.5.1194

T. Baumgarten, J. Vazquez, C. Bastisch, W. Veron, M. Feuilloley et al., Alkanols and chlorophenols cause different physiological adaptive responses on the level of cell surface properties and membrane vesicle formation in Pseudomonas putida DOT-T1E, Applied Microbiology and Biotechnology, vol.69, issue.2, 2012.
DOI : 10.1007/s00253-011-3442-9

J. Cox and M. Mann, MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification, Nature Biotechnology, vol.7, issue.12, pp.1367-1372, 2008.
DOI : 10.1038/nprot.2007.261

T. Pham, S. Piersma, M. Warmoes, and C. Jimenez, On the beta-binomial model for analysis of spectral count data in label-free tandem mass spectrometry-based proteomics, Bioinformatics, vol.26, issue.3, pp.363-369, 2010.
DOI : 10.1093/bioinformatics/btp677

L. Majlessi, M. Simsova, Z. Jarvis, P. Brodin, M. Rojas et al., An Increase in Antimycobacterial Th1-Cell Responses by Prime-Boost Protocols of Immunization Does Not Enhance Protection against Tuberculosis, Infection and Immunity, vol.74, issue.4, pp.2128-2137, 2006.
DOI : 10.1128/IAI.74.4.2128-2137.2006

S. Schlegel, E. Rujas, A. Ytterberg, R. Zubarev, J. Luirink et al., Optimizing heterologous protein production in the periplasm of E. coli by regulating gene expression levels, Microbial Cell Factories, vol.12, issue.1, pp.241475-2859, 2013.
DOI : 10.1016/j.jmb.2011.02.007

G. Christiansen and S. Birkelund, Is a Chlamydia vaccine a reality?, Best Practice & Research Clinical Obstetrics & Gynaecology, vol.16, issue.6, pp.889-900, 2002.
DOI : 10.1053/beog.2002.0324

W. Baehr, Y. Zhang, T. Joseph, H. Su, F. Nano et al., Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes., Proceedings of the National Academy of Sciences, vol.85, issue.11, pp.4000-4004, 1988.
DOI : 10.1073/pnas.85.11.4000

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC280348

S. Kim and R. Demars, Epitope clusters in the major outer membrane protein of Chlamydia trachomatis, Current Opinion in Immunology, vol.13, issue.4, pp.429-436, 2001.
DOI : 10.1016/S0952-7915(00)00237-5

P. Andersen, A. Andersen, A. Sorensen, and S. Nagai, Recall of longlived immunity to Mycobacterium tuberculosis infection in mice, J. Immunol, vol.154, pp.3359-3372, 1995.

A. Kulp and M. Kuehn, Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles, Annual Review of Microbiology, vol.64, issue.1, pp.163-184, 2010.
DOI : 10.1146/annurev.micro.091208.073413

B. Scorza, F. Colucci, A. Maggiore, L. Sanzone, S. Rossi et al., High yield production process for Shigella outer membrane particles, PLoS One, vol.7, issue.e35616, 2012.

B. Scorza, F. Doro, F. Rodriguez-ortega, M. Stella, M. Liberatori et al., Proteomics Characterization of Outer Membrane Vesicles from the Extraintestinal Pathogenic Escherichia coli ??tolR IHE3034 Mutant, Molecular & Cellular Proteomics, vol.7, issue.3, pp.473-485, 2008.
DOI : 10.1074/mcp.M700295-MCP200

G. Ferrari, I. Garaguso, J. Adu-bobie, F. Doro, A. Taddei et al., Outer membrane vesicles from group???BNeisseria meningitidis ??gna33 mutant: Proteomic and immunological comparison with detergent-derived outer membrane vesicles, PROTEOMICS, vol.267, issue.6, pp.1856-1866, 2006.
DOI : 10.1002/pmic.200500164

E. Lee, J. Bang, G. Park, D. Choi, J. Kang et al., Global proteomic profiling of native outer membrane vesicles derived fromEscherichia coli, PROTEOMICS, vol.63, issue.17, pp.3143-3153, 2007.
DOI : 10.1002/pmic.200700196

K. Braig, Z. Otwinowski, R. Hegde, D. Boisvert, A. Joachimiak et al., The crystal structure of the bacterial chaperonln GroEL at 2.8 ??, Nature, vol.371, issue.6498, pp.578-586, 1994.
DOI : 10.1038/371578a0

M. Marques, S. Chitale, P. Brennan, and M. Pessolani, Mapping and identification of the major cell wall-associated components of Mycobacterium leprae, Infect. Immun, vol.66, pp.2625-2631, 1998.

A. Boulanger, A. Francez-charlot, A. Conter, M. Castanie-cornet, C. K. Gutierrez et al., Multistress Regulation in Escherichia coli: Expression of osmB Involves Two Independent Promoters Responding either to ??S or to the RcsCDB His-Asp Phosphorelay, Journal of Bacteriology, vol.187, issue.9, pp.3282-3286, 2005.
DOI : 10.1128/JB.187.9.3282-3286.2005

M. Dupont, C. James, C. J. Pages, and J. , An Early Response to Environmental Stress Involves Regulation of OmpX and OmpF, Two Enterobacterial Outer Membrane Pore-Forming Proteins, Antimicrobial Agents and Chemotherapy, vol.51, issue.9, pp.3190-319801481, 2007.
DOI : 10.1128/AAC.01481-06

C. Aagaard, T. Hoang, J. Dietrich, P. Cardona, A. Izzo et al., A multistage tuberculosis vaccine that confers efficient protection before and after exposure, Nature Medicine, vol.182, issue.2, pp.189-194, 2011.
DOI : 10.1038/nm.2285

N. Tajima, F. Kawai, S. Park, and J. Tame, A Novel Intein-Like Autoproteolytic Mechanism in Autotransporter Proteins, Journal of Molecular Biology, vol.402, issue.4, pp.645-656, 2010.
DOI : 10.1016/j.jmb.2010.06.068