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Journal articles
Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups.
Abstract : Multidrug-resistant and highly virulent Klebsiella pneumoniae isolates are emerging, but the clonal groups (CGs) corresponding to these high-risk strains have remained imprecisely defined. We aimed to identify K. pneumoniae CGs on the basis of genome-wide sequence variation and to provide a simple bioinformatics tool to extract virulence and resistance gene data from genomic data. We sequenced 48 K. pneumoniae isolates, mostly of serotypes K1 and K2, and compared the genomes with 119 publicly available genomes. A total of 694 highly conserved genes were included in a core-genome multilocus sequence typing scheme, and cluster analysis of the data enabled precise definition of globally distributed hypervirulent and multidrug-resistant CGs. In addition, we created a freely accessible database, BIGSdb-Kp, to enable rapid extraction of medically and epidemiologically relevant information from genomic sequences of K. pneumoniae. Although drug-resistant and virulent K. pneumoniae populations were largely nonoverlapping, isolates with combined virulence and resistance features were detected.
Cited literature [39 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01118613
Contributor : Marie Lemesle <>
Submitted on : Thursday, February 19, 2015 - 2:38:28 PM
Last modification on : Monday, October 19, 2020 - 11:12:37 AM
Long-term archiving on: : Sunday, April 16, 2017 - 10:04:48 AM
Contributor : Marie Lemesle <>
Submitted on : Thursday, February 19, 2015 - 2:38:28 PM
Last modification on : Monday, October 19, 2020 - 11:12:37 AM
Long-term archiving on: : Sunday, April 16, 2017 - 10:04:48 AM
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14-0206.pdf
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