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Two-component systems and toxinogenesis regulation in Clostridium botulinum

Abstract : Botulinum neurotoxins (BoNTs) are the most potent toxins ever known. BoNTs associate with non-toxic proteins to form complexes of various sizes. Toxin production is highly regulated through complex networks of regulatory systems involving an alternative sigma factor, BotR, and at least 6 two-component systems (TCSs). TCSs allow bacteria to sense environmental changes and to respond to various stimuli by regulating the expression of specific genes at a transcriptional level. This review aims to highlight the role of TCSs as a central point in the regulation of toxin production in C. botulinum.
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Chloé Connan, Michel R. Popoff. Two-component systems and toxinogenesis regulation in Clostridium botulinum. Research in Microbiology, Elsevier, 2015, pii: S0923-2508(14)00261-7. ⟨10.1016/j.resmic.2014.12.012⟩. ⟨pasteur-01115185⟩

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