Salmonella enterica Serotype Typhi with nonclassical quinolone resistance phenotype.

Marie Accou-Demartin (1) , Valérie Gaborieau (2) , Yajun Song (3) , Philippe Roumagnac (4) , Bruno Marchou (2) , Mark Achtman (3) , François-Xavier Weill (5)

1 BPE - Bactéries pathogènes entériques
2 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
3 UCC - University College Cork
4 Cirad - Centre de Coopération Internationale en Recherche Agronomique pour le Développement
5 CNR - Centre National de Référence des Salmonella - Bactéries pathogènes entériques

We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.

Domaines: Bactériologie

Marie Accou-Demartin, Valérie Gaborieau, Yajun Song, Philippe Roumagnac, Bruno Marchou, et al.. Salmonella enterica Serotype Typhi with nonclassical quinolone resistance phenotype.. Emerging Infectious Diseases, 2011, 17 (6), pp.1091-4. ⟨10.3201/eid1706.101242⟩. ⟨pasteur-01115158⟩