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A Study of Negishi Cross-Coupling Reactions with Benzylzinc Halides To Prepare Original 3-Ethoxypyrazoles

Eloi P. Coutant 1 Yves L. Janin 1, *
* Corresponding author
Abstract : The Negishi palladium-catalyzed cross-coupling reaction between 3-ethoxy-4-iodo-1H-pyrazole and various benzylzinc halides was extensively studied. Using simplified, robust, and optimized reaction conditions, a series of electron-poor benzylzinc halides were prepared and used to synthesize 4-benzyl-3-ethoxy-1H-pyrazoles derivatives. From these, iodination on C5 of the pyrazole nucleus led to the corresponding 4-benzyl-3-ethoxy-5-iodo-1H-pyrazoles, these are original building blocks for the preparation of libraries of new chemical entities
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01111917
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Submitted on : Sunday, February 1, 2015 - 2:21:30 PM
Last modification on : Monday, January 13, 2020 - 5:08:16 PM

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Eloi P. Coutant, Yves L. Janin. A Study of Negishi Cross-Coupling Reactions with Benzylzinc Halides To Prepare Original 3-Ethoxypyrazoles. SYNTHESIS, Georg Thieme Verlag, 2015, 47 (4), pp.511-516. ⟨10.1055/s-0034-1379458⟩. ⟨pasteur-01111917⟩

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