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HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.

Abstract : Effective control of HIV-1 infection in humans is achieved using combinations of antiretroviral therapy (ART) drugs. In humanized mice (hu-mice), control of viremia can be achieved using either ART or by immunotherapy using combinations of broadly neutralizing antibodies (bNAbs). Here we show that treatment of HIV-1-infected hu-mice with a combination of three highly potent bNAbs not only resulted in complete viremic control but also led to a reduction in cell-associated HIV-1 DNA. Moreover, lowering the initial viral load by coadministration of ART and immunotherapy enabled prolonged viremic control by a single bNAb after ART was withdrawn. Similarly, a single injection of adeno-associated virus directing expression of one bNAb produced durable viremic control after ART was terminated. We conclude that immunotherapy reduces plasma viral load and cell-associated HIV-1 DNA and that decreasing the initial viral load enables single bNAbs to control viremia in hu-mice.
Keywords : CD4bs glycan gp160
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01109449
Contributor : Isma Ziani <>
Submitted on : Monday, January 26, 2015 - 1:27:02 PM
Last modification on : Friday, July 17, 2020 - 10:56:02 AM

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Joshua A Horwitz, Ariel Halper-Stromberg, Hugo Mouquet, Alexander D Gitlin, Anna Tretiakova, et al.. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2013, 110 (41), pp.16538-43. ⟨10.1073/pnas.1315295110⟩. ⟨pasteur-01109449⟩

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