HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread. - Archive ouverte HAL Access content directly
Journal Articles Immunity Year : 2001

HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread.

(1) , (1) , (1) , (2) , (3) , (2) , (1) , (3) , (1)
1
2
3

Abstract

DC-SIGN, a dendritic cell (DC)-specific lectin, mediates clustering of DCs with T lymphocytes, a crucial event in the initiation of immune responses. DC-SIGN also binds HIV envelope glycoproteins, allowing efficient virus capture by DCs. We show here that DC-SIGN surface levels are upregulated in HIV-1-infected DCs. This process is caused by the viral protein Nef, which acts by inhibiting DC-SIGN endocytosis. Upregulation of DC-SIGN at the cell surface dramatically increases clustering of DCs with T lymphocytes and HIV-1 transmission. These results provide new insights into how HIV-1 spreads from DCs to T lymphocytes and manipulates immune responses. They help explain how Nef may act as a virulence factor in vivo.
Fichier principal
Vignette du fichier
Immunity2002.pdf (467.2 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

pasteur-01107753 , version 1 (21-01-2015)

Identifiers

Cite

Nathalie Sol-Foulon, Arnaud Moris, Cinzia Nobile, Claire Boccaccio, Anneke Engering, et al.. HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread.. Immunity, 2001, 16 (1), pp.145-55. ⟨10.1016/S1074-7613(02)00260-1⟩. ⟨pasteur-01107753⟩
148 View
218 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More