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Journal articles
HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread.
Abstract : DC-SIGN, a dendritic cell (DC)-specific lectin, mediates clustering of DCs with T lymphocytes, a crucial event in the initiation of immune responses. DC-SIGN also binds HIV envelope glycoproteins, allowing efficient virus capture by DCs. We show here that DC-SIGN surface levels are upregulated in HIV-1-infected DCs. This process is caused by the viral protein Nef, which acts by inhibiting DC-SIGN endocytosis. Upregulation of DC-SIGN at the cell surface dramatically increases clustering of DCs with T lymphocytes and HIV-1 transmission. These results provide new insights into how HIV-1 spreads from DCs to T lymphocytes and manipulates immune responses. They help explain how Nef may act as a virulence factor in vivo.
Cited literature [22 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01107753
Contributor : Isma Ziani <>
Submitted on : Wednesday, January 21, 2015 - 3:00:45 PM
Last modification on : Monday, January 13, 2020 - 5:08:17 PM
Long-term archiving on: : Saturday, April 15, 2017 - 8:31:03 PM
Contributor : Isma Ziani <>
Submitted on : Wednesday, January 21, 2015 - 3:00:45 PM
Last modification on : Monday, January 13, 2020 - 5:08:17 PM
Long-term archiving on: : Saturday, April 15, 2017 - 8:31:03 PM
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Immunity2002.pdf
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