Skip to Main content Skip to Navigation
New interface
Journal articles

Sca-1(+) cardiac progenitor cells and heart-making: a critical synopsis.

Abstract : The identification, in the adult, of cardiomyocyte turnover events and of cardiac progenitor cells (CPCs) has revolutionized the field of cardiovascular medicine. However, the low rate of CPCs differentiation events reported both in vitro and in vivo, even after injury, raised concerns on the biological significance of these subsets. In this Comprehensive Review, we discuss the current understanding of cardiac Lin(-)Sca-1(+) cells in light of what is also known for cellular compartments with similar phenotypes in other organs. The Lin(-)Sca-1(+) heart subset is heterogeneous and displays a mesenchymal profile, characterized by a limited ability to generate cardiomyocytes in vitro and in vivo, even after injury. There is no evidence for Sca-1 expression in embryonic cardiovascular progenitors. In other organs, Sca-1 expression is mainly observed on mesoderm-derived cells, although it is not restricted to stem/progenitor cell populations. It is urgent to determine, at a single cell level, to which extent cardiac Lin(-)Sca-1(+) cells overlap with the fibroblast compartment.
Document type :
Journal articles
Complete list of metadata

Cited literature [106 references]  Display  Hide  Download
Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Monday, October 6, 2014 - 12:36:35 PM
Last modification on : Friday, April 22, 2022 - 11:42:04 AM
Long-term archiving on: : Thursday, January 8, 2015 - 4:10:58 PM


Publisher files allowed on an open archive




Mariana Valente, Diana Santos Nascimento, Ana Cumano, Perpétua Pinto-Do-Ó. Sca-1(+) cardiac progenitor cells and heart-making: a critical synopsis.. Stem Cells and Development, 2014, 23 (19), pp.2263-73. ⟨10.1089/scd.2014.0197⟩. ⟨pasteur-01071565⟩



Record views


Files downloads