Skip to Main content Skip to Navigation
Journal articles

Role of skin immune cells on the host susceptibility to mosquito-borne viruses.

Abstract : Due to climate change and the propagation of competent arthropods worldwide, arboviruses have become pathogens of major medical importance. Early transmission to vertebrates is initiated by skin puncture and deposition of virus together with arthropod saliva in the epidermis and dermis. Saliva components have the capacity to modulate skin cell responses by enhancing and/or counteracting initial replication and establishment of systemic viral infection. Here, we review the nature of the cells targeted by arboviruses at the skin level and discuss the type of cellular responses elicited by these pathogens in light of the immunomodulatory properties of arthropod vector-derived salivary factors injected at the inoculation site. Understanding cutaneous arbovirus-host interactions may provide new clues for the design of future therapeutics.
Document type :
Journal articles
Complete list of metadatas

Cited literature [68 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01054562
Contributor : Valérie Choumet <>
Submitted on : Thursday, August 7, 2014 - 1:35:44 PM
Last modification on : Friday, May 15, 2020 - 6:48:02 PM
Long-term archiving on: : Tuesday, April 11, 2017 - 7:20:58 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Laurence Briant, Philippe Desprès, Valérie Choumet, Dorothée Missé. Role of skin immune cells on the host susceptibility to mosquito-borne viruses.. Virology, Elsevier, 2014, pp.26-32. ⟨10.1016/j.virol.2014.06.023⟩. ⟨pasteur-01054562⟩

Share

Metrics

Record views

341