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Human Hematopoietic Reconstitution and HLA-Restricted Responses in Nonpermissive Alymphoid Mice.

Abstract : We generated a new humanized mouse model to study HLA-restricted immune responses. For this purpose, we created unique murine hosts by enforcing the expression of human SIRPα by murine phagocytes in murine MHC-deficient HLA-transgenic alymphoid hosts, an approach that allowed the immune reconstitution of nonpermissive mice following injection of human hematopoietic stem cells. We showed that these mouse/human chimeras were able to generate HLA-restricted responses to immunization. These new humanized mice may offer attractive models to study immune responses to human diseases, such as HIV and EBV infections, as well as to assay new vaccine strategies.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01052571
Contributor : Marie-Christine Vougny <>
Submitted on : Monday, July 28, 2014 - 10:51:02 AM
Last modification on : Thursday, June 18, 2020 - 5:38:03 PM

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Malika Serra-Hassoun, Maryline Bourgine, Michele Boniotto, Julien Berges, Francina Langa, et al.. Human Hematopoietic Reconstitution and HLA-Restricted Responses in Nonpermissive Alymphoid Mice.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2014, 193 (3), pp.1504-11. ⟨10.4049/jimmunol.1400412⟩. ⟨pasteur-01052571⟩

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