M. Callaghan and S. Mcclean, Bacterial host interactions in cystic fibrosis, Current Opinion in Microbiology, vol.15, issue.1, pp.71-77, 2012.
DOI : 10.1016/j.mib.2011.11.001

T. Cohen and A. Prince, Cystic fibrosis: a mucosal immunodeficiency syndrome, Nature Medicine, vol.17, issue.4, pp.509-519, 2012.
DOI : 10.1016/j.cell.2010.11.029

C. Goss and J. Burns, Exacerbations in cystic fibrosis {middle dot} 1: Epidemiology and pathogenesis, Thorax, vol.62, issue.4, pp.360-367, 2007.
DOI : 10.1136/thx.2006.060889

A. Stenbit and P. Flume, Pulmonary exacerbations in cystic fibrosis, Current Opinion in Pulmonary Medicine, vol.17, pp.442-447, 2011.
DOI : 10.1097/MCP.0b013e32834b8c04

S. Chotirmall, S. Smith, C. Gunaratnam, S. Cosgrove, B. Dimitrov et al., Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis, New England Journal of Medicine, vol.366, issue.21, pp.1978-1986, 2012.
DOI : 10.1056/NEJMoa1106126

V. Waters and F. Ratjen, Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis, Cochrane Database Syst Rev, vol.3, p.6961, 2008.

D. Bilton, G. Canny, S. Conway, S. Dumcius, L. Hjelte et al., Pulmonary exacerbation: Towards a definition for use in clinical trials. Report from the EuroCareCF Working Group on outcome parameters in clinical trials, Journal of Cystic Fibrosis, vol.10, issue.2, pp.79-81, 2011.
DOI : 10.1016/S1569-1993(11)60012-X

V. Feuillet, S. Medjane, I. Mondor, O. Demaria, P. Pagni et al., Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria, Proceedings of the National Academy of Sciences, vol.103, issue.33, pp.12487-12492, 2006.
DOI : 10.1073/pnas.0605200103
URL : https://hal.archives-ouvertes.fr/hal-00165595

S. Skerrett, C. Wilson, H. Liggitt, and A. Hajjar, Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa, AJP: Lung Cellular and Molecular Physiology, vol.292, issue.1
DOI : 10.1152/ajplung.00250.2006

R. Ramphal, V. Balloy, J. Jyot, A. Verma, M. Si-tahar et al., Control of Pseudomonas aeruginosa in the Lung Requires the Recognition of Either Lipopolysaccharide or Flagellin, The Journal of Immunology, vol.181, issue.1, pp.586-592, 2008.
DOI : 10.4049/jimmunol.181.1.586
URL : https://hal.archives-ouvertes.fr/pasteur-00277620

R. Adamo, S. Sokol, G. Soong, M. Gomez, and A. Prince, Flagella Activate Airway Epithelial Cells through asialoGM1 and Toll-Like Receptor 2 as well as Toll-Like Receptor 5, American Journal of Respiratory Cell and Molecular Biology, vol.30, issue.5, pp.627-634, 2004.
DOI : 10.1165/rcmb.2003-0260OC

K. Oshikawa and A. Sugiyama, Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage, Biochemical and Biophysical Research Communications, vol.305, issue.3, pp.649-655, 2003.
DOI : 10.1016/S0006-291X(03)00837-4

L. Guillot, S. Medjane, K. Le-barillec, V. Balloy, C. Danel et al., Response of Human Pulmonary Epithelial Cells to Lipopolysaccharide Involves Toll-like Receptor 4 (TLR4)-dependent Signaling Pathways, Journal of Biological Chemistry, vol.279, issue.4, pp.2712-2718, 2004.
DOI : 10.1074/jbc.M305790200

H. Ramos, M. Rumbo, and J. Sirard, Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa, Trends in Microbiology, vol.12, issue.11, pp.509-517, 2004.
DOI : 10.1016/j.tim.2004.09.002
URL : https://hal.archives-ouvertes.fr/inserm-00000046

Z. Zhang, J. Louboutin, D. Weiner, J. Goldberg, and J. Wilson, Human Airway Epithelial Cells Sense Pseudomonas aeruginosa Infection via Recognition of Flagellin by Toll-Like Receptor 5, Infection and Immunity, vol.73, issue.11, pp.7151-7160, 2005.
DOI : 10.1128/IAI.73.11.7151-7160.2005

A. Hajjar, R. Ernst, J. Tsai, C. Wilson, and S. Miller, Human Toll-like receptor 4 recognizes host-specific LPS modifications, Nature Immunology, vol.3, issue.4, pp.354-359, 2002.
DOI : 10.1038/ni777

M. Luzar, M. Thomassen, and T. Montie, Flagella and motility alterations in Pseudomonas aeruginosa strains from patients with cystic fibrosis: relationship to patient clinical condition, Infect Immun, vol.50, pp.577-582, 1985.

M. Wolfgang, J. Jyot, A. Goodman, R. Ramphal, and L. S. , Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients, Proceedings of the National Academy of Sciences, vol.101, issue.17, pp.6664-6668, 2004.
DOI : 10.1073/pnas.0307553101

A. Sonawane, J. Jyot, R. During, and R. Ramphal, Neutrophil Elastase, an Innate Immunity Effector Molecule, Represses Flagellin Transcription in Pseudomonas aeruginosa, Infection and Immunity, vol.74, issue.12, pp.6682-6689, 2006.
DOI : 10.1128/IAI.00922-06

Y. López-boado, M. Espinola, S. Bahr, and A. Belaaouaj, Neutrophil Serine Proteinases Cleave Bacterial Flagellin, Abrogating Its Host Response-Inducing Activity, The Journal of Immunology, vol.172, issue.1, pp.509-515, 2004.
DOI : 10.4049/jimmunol.172.1.509

K. Sauer, A. Camper, G. Ehrlich, J. Costerton, and D. Davies, Pseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm, Journal of Bacteriology, vol.184, issue.4, pp.1140-1154, 2002.
DOI : 10.1128/jb.184.4.1140-1154.2002

V. Wagner and B. Iglewski, P. aeruginosa Biofilms in CF Infection, Clinical Reviews in Allergy & Immunology, vol.112, issue.10, pp.124-134, 2008.
DOI : 10.1007/s12016-008-8079-9
URL : https://hal.archives-ouvertes.fr/in2p3-00022839

M. Whiteley, M. Bangera, R. Bumgarner, M. Parsek, G. Teitzel et al., Gene expression in Pseudomonas aeruginosa biofilms, Nature, vol.413, issue.6858, pp.860-864, 2001.
DOI : 10.1038/35101627

M. Klausen, A. Heydorn, P. Ragas, L. Lambertsen, A. Aaes-jørgensen et al., Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants, Molecular Microbiology, vol.413, issue.6, pp.1511-1524, 2003.
DOI : 10.1046/j.1365-2958.2003.03525.x

A. Verma, S. Arora, S. Kuravi, and R. Ramphal, Roles of Specific Amino Acids in the N Terminus of Pseudomonas aeruginosa Flagellin and of Flagellin Glycosylation in the Innate Immune Response, Infection and Immunity, vol.73, issue.12, pp.8237-8246, 2005.
DOI : 10.1128/IAI.73.12.8237-8246.2005

T. Lee, K. Brownlee, S. Conway, M. Denton, and J. Littlewood, Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients, Journal of Cystic Fibrosis, vol.2, issue.1, pp.29-34, 2003.
DOI : 10.1016/S1569-1993(02)00141-8

H. Fuchs, D. Borowitz, D. Christiansen, E. Morris, M. Nash et al., Effect of Aerosolized Recombinant Human DNase on Exacerbations of Respiratory Symptoms and on Pulmonary Function in Patients with Cystic Fibrosis, New England Journal of Medicine, vol.331, issue.10, pp.637-642, 1994.
DOI : 10.1056/NEJM199409083311003

S. Arora, N. Dasgupta, S. Lory, and R. Ramphal, Identification of Two Distinct Types of Flagellar Cap Proteins, FliD, in Pseudomonas aeruginosa, Infection and Immunity, vol.68, issue.3, pp.1474-1479, 2000.
DOI : 10.1128/IAI.68.3.1474-1479.2000

S. Mcisaac, A. Stadnyk, and T. Lin, Toll-like receptors in the host defense against Pseudomonas aeruginosa respiratory infection and cystic fibrosis, Journal of Leukocyte Biology, vol.92, issue.5, pp.977-985, 2012.
DOI : 10.1189/jlb.0811410

C. Blohmke, J. Park, A. Hirschfeld, R. Victor, J. Schneiderman et al., TLR5 as an Anti-Inflammatory Target and Modifier Gene in Cystic Fibrosis, The Journal of Immunology, vol.185, issue.12, pp.57731-7738, 2010.
DOI : 10.4049/jimmunol.1001513

N. Rieber, A. Brand, A. Hector, U. Graepler-mainka, M. Ost et al., Flagellin Induces Myeloid-Derived Suppressor Cells: Implications for Pseudomonas aeruginosa Infection in Cystic Fibrosis Lung Disease, The Journal of Immunology, vol.190, issue.3, pp.1276-1284, 2013.
DOI : 10.4049/jimmunol.1202144

M. Workentine, C. Sibley, B. Glezerson, S. Purighalla, J. Norgaard-gron et al., Phenotypic Heterogeneity of Pseudomonas aeruginosa Populations in a Cystic Fibrosis Patient, PLoS ONE, vol.33, issue.1, p.60225, 2013.
DOI : 10.1371/journal.pone.0060225.s010