M. Taha and P. Olcén, Molecular genetic methods in diagnosis and direct characterization of acute bacterial central nervous system infections, APMIS, vol.31, issue.3, pp.11-12753, 2004.
DOI : 10.1128/JCM.41.6.2605-2615.2003

D. Van-de-beek, J. De-gans, L. Spanjaard, M. Weisfelt, J. Reitsma et al., Clinical Features and Prognostic Factors in Adults with Bacterial Meningitis, New England Journal of Medicine, vol.351, issue.18, pp.3511849-1859, 2004.
DOI : 10.1056/NEJMoa040845

D. Gendrel, R. J. Assicot, M. Moulin, F. Iniguez, J. Lebon et al., Measurement of Procalcitonin Levels in Children with Bacterial or Viral Meningitis, Clinical Infectious Diseases, vol.24, issue.6, pp.1240-1242, 1997.
DOI : 10.1086/513633

A. Spanos, F. Harrell, . Jr, and D. Durack, Differential Diagnosis of Acute Meningitis, JAMA, vol.262, issue.19, pp.2700-2707, 1989.
DOI : 10.1001/jama.1989.03430190084036

P. Brogan and A. Raffles, Short report: The management of fever and petechiae: making sense of rash decisions, Archives of Disease in Childhood, vol.83, issue.6, pp.506-507, 2000.
DOI : 10.1136/adc.83.6.506

C. Richards, A. Thimm, J. Clark, A. Thomson, T. Newton et al., The management of fever and petechiae: collaborative studies are needed Replies, Archives of Disease in Childhood, vol.85, issue.2, p.172, 2001.
DOI : 10.1136/adc.85.2.172a

H. Peltola, C-REACTIVE PROTEIN FOR RAPID MONITORING OF INFECTIONS OF THE CENTRAL NERVOUS SYSTEM, The Lancet, vol.319, issue.8279, pp.980-982, 1982.
DOI : 10.1016/S0140-6736(82)91989-4

L. Simon, F. Gauvin, D. Amre, P. Saint-louis, and J. Lacroix, Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-analysis, Clinical Infectious Diseases, vol.39, issue.2, pp.206-217, 2004.
DOI : 10.1086/421997

J. Yang, D. Goetz, J. Li, W. Wang, K. Mori et al., An Iron Delivery Pathway Mediated by a Lipocalin, Molecular Cell, vol.10, issue.5, pp.1045-1056, 2002.
DOI : 10.1016/S1097-2765(02)00710-4

L. Kjeldsen, A. Johnsen, H. Sengelov, and N. Borregaard, Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase, J Biol Chem, vol.268, issue.14, pp.10425-10432, 1993.

T. Flo, K. Smith, S. Sato, D. Rodriguez, M. Holmes et al., Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron, Nature, vol.1482, issue.7019, pp.432917-921, 2004.
DOI : 10.1016/S0020-1693(97)05664-8

D. Goetz, M. Holmes, N. Borregaard, M. Bluhm, K. Raymond et al., The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition, Molecular Cell, vol.10, issue.5, pp.1033-1043, 2002.
DOI : 10.1016/S1097-2765(02)00708-6

M. Szatanik, E. Hong, C. Ruckly, M. Ledroit, D. Giorgini et al., Experimental Meningococcal Sepsis in Congenic Transgenic Mice Expressing Human Transferrin, PLoS ONE, vol.137, issue.7, p.22210, 2011.
DOI : 10.1371/journal.pone.0022210.t005

F. Marques, A. Rodrigues, J. Sousa, G. Coppola, D. Geschwind et al., Lipocalin 2 is a Choroid Plexus Acute-Phase Protein, Journal of Cerebral Blood Flow & Metabolism, vol.28, issue.3, pp.450-455, 2008.
DOI : 10.1002/pmic.200600096

M. Taha, J. Alonso, M. Cafferkey, D. Caugant, S. Clarke et al., Interlaboratory Comparison of PCR-Based Identification and Genogrouping of Neisseria meningitidis, Journal of Clinical Microbiology, vol.43, issue.1, pp.144-149, 2005.
DOI : 10.1128/JCM.43.1.144-149.2005

A. Deghmane, I. Parent-du-chatelet, M. Szatanik, E. Hong, C. Ruckly et al., Serogroup C Sequence Type 11 Isolates in France, The Journal of Infectious Diseases, vol.202, issue.2, pp.247-250, 2010.
DOI : 10.1086/653583

M. Taha, P. Morand, Y. Pereira, E. Eugene, D. Giorgini et al., Pilus-mediated adhesion of Neisseria meningitidis: the essential role of cell contact-dependent transcriptional upregulation of the PilC1 protein, Molecular Microbiology, vol.273, issue.6, pp.281153-1163, 1998.
DOI : 10.1038/373357a0

M. Zarantonelli, M. Szatanik, D. Giorgini, E. Hong, M. Huerre et al., Transgenic Mice Expressing Human Transferrin as a Model for Meningococcal Infection, Infection and Immunity, vol.75, issue.12, pp.755609-5614, 2007.
DOI : 10.1128/IAI.00781-07

L. Liu and K. Duff, A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse, Journal of Visualized Experiments, vol.21, issue.21, pp.1-3, 2008.
DOI : 10.3791/960

B. Dupuy, M. Taha, A. Pugsley, and C. Marchal, Neisseria gonorrhoeae prepilin export studied in Escherichia coli., Journal of Bacteriology, vol.173, issue.23, pp.7589-7598, 1991.
DOI : 10.1128/jb.173.23.7589-7598.1991

A. Deghmane, C. Veckerle, D. Giorgini, E. Hong, C. Ruckly et al., Differential Modulation of TNF-?????Induced Apoptosis by Neisseria meningitidis, PLoS Pathogens, vol.7, issue.5, p.1000405, 2009.
DOI : 10.1371/journal.ppat.1000405.s004

M. Taha, Simultaneous approach for nonculture PCR-based identification and serogroup prediction of Neisseria meningitidis, J Clin Microbiol, vol.38, issue.2, pp.855-857, 2000.

H. Peltola and M. Jaakkola, C-reactive protein in early detection of bacteremic versus viral infections in immunocompetent and compromised children, The Journal of Pediatrics, vol.113, issue.4, pp.641-646, 1988.
DOI : 10.1016/S0022-3476(88)80372-X

L. Hansson, G. Axelsson, T. Linne, E. Aurelius, and L. Lindquist, Serum C-reactive Protein in the Differential Diagnosis of Acute Meningitis, Scandinavian Journal of Infectious Diseases, vol.61, issue.5, pp.625-630, 1993.
DOI : 10.3109/00365517209080258

P. Dandona, D. Nix, M. Wilson, A. Aljada, J. Love et al., Procalcitonin increase after endotoxin injection in normal subjects, J Clin Endocrinol Metab, vol.79, issue.6, pp.1605-1608, 1994.

M. Durand, S. Calderwood, D. Weber, S. Miller, F. Southwick et al., Acute Bacterial Meningitis in Adults -- A Review of 493 Episodes, New England Journal of Medicine, vol.328, issue.1, pp.21-28, 1993.
DOI : 10.1056/NEJM199301073280104

F. Brivet, S. Ducuing, F. Jacobs, I. Chary, R. Pompier et al., Accuracy of clinical presentation for differentiating bacterial from viral meningitis in adults: a multivariate approach, Intensive Care Medicine, vol.30, issue.12, pp.311654-1660, 2005.
DOI : 10.1007/s00134-005-2811-1

F. Dubos, F. De-la-rocque, C. Levy, E. Bingen, Y. Aujard et al., Sensitivity of the Bacterial Meningitis Score in 889 Children with Bacterial Meningitis, The Journal of Pediatrics, vol.152, issue.3, pp.378-382, 2008.
DOI : 10.1016/j.jpeds.2007.07.012

A. Bouchon, F. Facchetti, M. Weigand, and M. Colonna, TREM-1 amplifies inflammation and is a crucial mediator of septic shock, Nature, issue.6832, pp.4101103-1107, 2001.

E. Carrol, L. Mankhambo, G. Jeffers, D. Parker, M. Guiver et al., The Diagnostic and Prognostic Accuracy of Five Markers of Serious Bacterial Infection in Malawian Children with Signs of Severe Infection, PLoS ONE, vol.9, issue.8, p.6621, 2009.
DOI : 10.1371/journal.pone.0006621.t003

E. Carrol, A. Thomson, and C. Hart, Procalcitonin as a marker of sepsis, International Journal of Antimicrobial Agents, vol.20, issue.1, pp.1-9, 2002.
DOI : 10.1016/S0924-8579(02)00047-X

H. Azuma, N. Tsuda, K. Sasaki, and A. Okuno, Clinical significance of cytokine measurement for detection of meningitis, The Journal of Pediatrics, vol.131, issue.3, pp.463-465, 1997.
DOI : 10.1016/S0022-3476(97)80079-0

A. Viallon, N. Desseigne, O. Marjollet, A. Birynczyk, M. Belin et al., Meningitis in adult patients with a negative direct cerebrospinal fluid examination: value of cytochemical markers for differential diagnosis, Critical Care, vol.15, issue.3, p.136, 2011.
DOI : 10.1016/S0929-693X(01)00793-X

A. Linder, P. Akesson, M. Brink, M. Studahl, L. Bjorck et al., Heparin-binding protein: A diagnostic marker of acute bacterial meningitis*, Critical Care Medicine, vol.39, issue.4, pp.812-817, 2011.
DOI : 10.1097/CCM.0b013e318206c396

G. Srinivasan, J. Aitken, B. Zhang, F. Carvalho, B. Chassaing et al., Lipocalin 2 Deficiency Dysregulates Iron Homeostasis and Exacerbates Endotoxin-Induced Sepsis, The Journal of Immunology, vol.189, issue.4, pp.1911-1919
DOI : 10.4049/jimmunol.1200892
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411903

S. Chakraborty, S. Kaur, S. Guha, and S. Batra, The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1826, issue.1, pp.129-169
DOI : 10.1016/j.bbcan.2012.03.008

. Guiddir, Lipocalin 2 in cerebrospinal fluid as a marker of acute bacterial meningitis, BMC Infectious Diseases, vol.1826, issue.1, p.276, 2014.
DOI : 10.4049/jimmunol.1200892
URL : https://hal.archives-ouvertes.fr/pasteur-00996794