Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus. - Archive ouverte HAL Access content directly
Journal Articles Nature Immunology Year : 2014

Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus.

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Abstract

The generation of T cells depends on the migration of hematopoietic progenitor cells to the thymus throughout life. The identity of the thymus-settling progenitor cells has been a matter of considerable debate. Here we found that thymopoiesis was initiated by a first wave of T cell lineage-restricted progenitor cells with limited capacity for population expansion but accelerated differentiation into mature T cells. They gave rise to αβ and γδ T cells that constituted Vγ3(+) dendritic epithelial T cells. Thymopoiesis was subsequently maintained by less-differentiated progenitor cells that retained the potential to develop into B cells and myeloid cells. In that second wave, which started before birth, progenitor cells had high proliferative capacity but delayed differentiation capacity and no longer gave rise to embryonic γδ T cells. Our work reconciles conflicting hypotheses on the nature of thymus-settling progenitor cells.
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Dates and versions

pasteur-00932592 , version 1 (17-01-2014)

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Cyrille Ramond, Claire Berthault, Odile Burlen-Defranoux, Ana Pereira de Sousa, Delphine Guy-Grand, et al.. Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus.. Nature Immunology, 2014, 15 (1), pp.27-35. ⟨10.1038/ni.2782⟩. ⟨pasteur-00932592⟩
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