A. Zaki, S. Van-boheemen, T. Bestebroer, A. Osterhaus, and R. Fouchier, Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia, New England Journal of Medicine, vol.367, issue.19, pp.1814-1820, 2012.
DOI : 10.1056/NEJMoa1211721

S. Perlman and J. Netland, Coronaviruses post-SARS: update on replication and pathogenesis, Nature Reviews Microbiology, vol.74, issue.6, pp.439-450, 2009.
DOI : 10.1038/nrmicro2147

C. Drosten, S. Gunther, W. Preiser, S. Van-der-werf, and H. Brodt, Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory Syndrome, New England Journal of Medicine, vol.348, issue.20, pp.1967-1976, 2003.
DOI : 10.1056/NEJMoa030747
URL : https://hal.archives-ouvertes.fr/pasteur-00167033

T. Ksiazek, D. Erdman, C. Goldsmith, S. Zaki, and T. Peret, A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome, New England Journal of Medicine, vol.348, issue.20, pp.1953-1966, 2003.
DOI : 10.1056/NEJMoa030781

J. Peiris, S. Lai, L. Poon, Y. Guan, and L. Yam, Coronavirus as a possible cause of severe acute respiratory syndrome, The Lancet, vol.361, issue.9366, pp.1319-1325, 2003.
DOI : 10.1016/S0140-6736(03)13077-2

. Promed-mail, Novel coronavirus -Saudi Arabia: human isolate, 2012.

D. Vijaykrishna, G. Smith, J. Zhang, J. Peiris, and H. Chen, Evolutionary Insights into the Ecology of Coronaviruses, Journal of Virology, vol.81, issue.8, pp.4012-4020, 2007.
DOI : 10.1128/JVI.02605-06

S. Pfefferle, S. Oppong, J. Drexler, F. Gloza-rausch, and A. Ipsen, Distant Relatives of Severe Acute Respiratory Syndrome Coronavirus and Close Relatives of Human Coronavirus 229E in Bats, Ghana, Emerging Infectious Diseases, vol.15, issue.9, pp.1377-1384, 2009.
DOI : 10.3201/eid1509.090224

F. Gloza-rausch, A. Ipsen, A. Seebens, M. Gottsche, and M. Panning, Detection and Prevalence Patterns of Group I Coronaviruses in Bats, Northern Germany, Emerging Infectious Diseases, vol.14, issue.4, pp.626-631, 2008.
DOI : 10.3201/eid1404.071439

J. Huynh, S. Li, B. Yount, A. Smith, and L. Sturges, Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63, Journal of Virology, vol.86, issue.23, pp.12816-12825, 2012.
DOI : 10.1128/JVI.00906-12

S. Van-boheemen, M. De-graaf, C. Lauber, T. Bestebroer, and V. Raj, Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans, mBio, vol.3, issue.6, pp.473-485, 2012.
DOI : 10.1128/mBio.00473-12

A. Bermingham, M. Chand, C. Brown, E. Aarons, and C. Tong, Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, Euro Surveill, vol.17, p.20290, 2012.

. Promed, . Jordan, . Id, and R. Who, MERS-CoV -Eastern Mediterranean, 2013.

V. Raj, H. Mou, S. Smits, D. Dekkers, and M. Muller, Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC, Nature, vol.3, issue.7440, pp.251-254, 2013.
DOI : 10.1016/j.stem.2010.02.014

E. Minskaia, T. Hertzig, A. Gorbalenya, V. Campanacci, and C. Cambillau, Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis, Proceedings of the National Academy of Sciences, vol.103, issue.13, pp.5108-5113, 2006.
DOI : 10.1073/pnas.0508200103

A. Gorbalenya, L. Enjuanes, J. Ziebuhr, and E. Snijder, Nidovirales: Evolving the largest RNA virus genome, Virus Research, vol.117, issue.1, pp.17-37, 2006.
DOI : 10.1016/j.virusres.2006.01.017

E. Smith and M. Denison, Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses, Current Opinion in Virology, vol.2, issue.5, pp.519-524, 2012.
DOI : 10.1016/j.coviro.2012.07.005

Y. Zuo and M. Deutscher, Exoribonuclease superfamilies: structural analysis and phylogenetic distribution, Nucleic Acids Research, vol.29, issue.5, pp.1017-1026, 2001.
DOI : 10.1093/nar/29.5.1017
URL : http://doi.org/10.1093/nar/29.5.1017

L. Eckerle, M. Becker, R. Halpin, K. Li, and E. Venter, Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing, PLoS Pathogens, vol.78, issue.5, p.1000896, 2010.
DOI : 10.1371/journal.ppat.1000896.s010

L. Eckerle, X. Lu, S. Sperry, L. Choi, and M. Denison, High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants, Journal of Virology, vol.81, issue.22, pp.12135-12144, 2007.
DOI : 10.1128/JVI.01296-07

R. Graham, M. Becker, L. Eckerle, M. Bolles, and M. Denison, A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease, Nature Medicine, vol.110, issue.12, pp.1820-1826, 2012.
DOI : 10.1073/pnas.0808116105

M. Bouvet, I. Imbert, L. Subissi, L. Gluais, and B. Canard, RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex, Proceedings of the National Academy of Sciences, vol.109, issue.24, pp.9372-9377, 2012.
DOI : 10.1073/pnas.1201130109

S. Crotty, C. Cameron, and R. Andino, RNA virus error catastrophe: Direct molecular test by using ribavirin, Proceedings of the National Academy of Sciences, vol.98, issue.12, pp.6895-6900, 2001.
DOI : 10.1073/pnas.111085598

S. Crotty, D. Maag, J. Arnold, W. Zhong, and J. Lau, The broadspectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen, Nat Med, vol.6, pp.1375-1379, 2000.

H. Chiou, C. Liu, M. Buttrey, H. Kuo, and H. Liu, Adverse Effects of Ribavirin and Outcome in Severe Acute Respiratory Syndrome, Chest, vol.128, issue.1, pp.263-272, 2005.
DOI : 10.1378/chest.128.1.263

M. Muller, L. Dresser, J. Raboud, A. Mcgeer, and E. Rea, Adverse Events Associated with High-Dose Ribavirin: Evidence from the Toronto Outbreak of Severe Acute Respiratory Syndrome, Pharmacotherapy, vol.107, issue.4, pp.494-503, 2007.
DOI : 10.1002/hep.20111

D. Barnard, C. Day, K. Bailey, M. Heiner, and R. Montgomery, Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin, Antiviral Research, vol.71, issue.1, pp.53-63, 2006.
DOI : 10.1016/j.antiviral.2006.03.001

L. Stockman, R. Bellamy, and P. Garner, SARS: Systematic Review of Treatment Effects, PLoS Medicine, vol.349, issue.9, p.343, 2006.
DOI : 10.1371/journal.pmed.0030343.st011

A. Grande-perez, S. Sierra, M. Castro, E. Domingo, and P. Lowenstein, Molecular indetermination in the transition to error catastrophe: Systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity, Proceedings of the National Academy of Sciences, vol.99, issue.20, pp.12938-12943, 2002.
DOI : 10.1073/pnas.182426999

B. Yount, M. Denison, S. Weiss, and R. Baric, Systematic Assembly of a Full-Length Infectious cDNA of Mouse Hepatitis Virus Strain A59, Journal of Virology, vol.76, issue.21, pp.11065-11078, 2002.
DOI : 10.1128/JVI.76.21.11065-11078.2002

B. Yount, K. Curtis, E. Fritz, L. Hensley, and P. Jahrling, Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus, Proceedings of the National Academy of Sciences, vol.100, issue.22, pp.12995-13000, 2003.
DOI : 10.1073/pnas.1735582100

K. Livak and T. Schmittgen, Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2???????CT Method, Methods, vol.25, issue.4, pp.402-408, 2001.
DOI : 10.1006/meth.2001.1262

E. Donaldson, A. Sims, R. Graham, M. Denison, and R. Baric, Murine Hepatitis Virus Replicase Protein nsp10 Is a Critical Regulator of Viral RNA Synthesis, Journal of Virology, vol.81, issue.12, pp.6356-6368, 2007.
DOI : 10.1128/JVI.02805-06

E. Donaldson, A. Sims, D. Deming, and R. Baric, Mutational Analysis of MHV-A59 Replicase Protein-NSP10, Adv Exp Med Biol, vol.581, pp.61-66, 2006.
DOI : 10.1007/978-0-387-33012-9_9

N. Gnadig, S. Beaucourt, G. Campagnola, A. Borderia, and M. Sanz-ramos, Coxsackievirus B3 mutator strains are attenuated in vivo, Proceedings of the National Academy of Sciences, vol.109, issue.34, pp.2294-2303, 2012.
DOI : 10.1073/pnas.1204022109
URL : https://hal.archives-ouvertes.fr/pasteur-00918212

H. Li and R. Durbin, Fast and accurate short read alignment with Burrows-Wheeler transform, Bioinformatics, vol.25, issue.14, pp.1754-1760, 2009.
DOI : 10.1093/bioinformatics/btp324

H. Li, B. Handsaker, A. Wysoker, T. Fennell, and J. Ruan, The Sequence Alignment/Map format and SAMtools, Bioinformatics, vol.25, issue.16, pp.2078-2079, 2009.
DOI : 10.1093/bioinformatics/btp352

S. Crotty, C. Cameron, and R. Andino, Ribavirin's antiviral mechanism of action: lethal mutagenesis?, Journal of Molecular Medicine, vol.80, issue.2, pp.86-95, 2002.
DOI : 10.1007/s00109-001-0308-0

R. Agudo, C. Ferrer-orta, A. Arias, I. De-la-higuera, and C. Perales, A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape, PLoS Pathogens, vol.285, issue.8, p.1001072, 2010.
DOI : 10.1371/journal.ppat.1001072.s003

A. Arias, J. Arnold, M. Sierra, E. Smidansky, and E. Domingo, Determinants of RNA-Dependent RNA Polymerase (In)fidelity Revealed by Kinetic Analysis of the Polymerase Encoded by a Foot-and-Mouth Disease Virus Mutant with Reduced Sensitivity to Ribavirin, Journal of Virology, vol.82, issue.24, pp.12346-12355, 2008.
DOI : 10.1128/JVI.01297-08

D. Maag, C. Castro, Z. Hong, and C. Cameron, Hepatitis C Virus RNA-dependent RNA Polymerase (NS5B) as a Mediator of the Antiviral Activity of Ribavirin, Journal of Biological Chemistry, vol.276, issue.49, pp.46094-46098, 2001.
DOI : 10.1074/jbc.C100349200

M. Sierra, A. Airaksinen, C. Gonzalez-lopez, R. Agudo, and A. Arias, Foot-and-Mouth Disease Virus Mutant with Decreased Sensitivity to Ribavirin: Implications for Error Catastrophe, Journal of Virology, vol.81, issue.4, pp.2012-2024, 2007.
DOI : 10.1128/JVI.01606-06

K. Kamiya, P. Huang, and W. Plunkett, Inhibition of the 3' -> 5' Exonuclease of Human DNA Polymerase ?? by Fludarabine-terminated DNA, Journal of Biological Chemistry, vol.271, issue.32, pp.19428-19435, 1996.
DOI : 10.1074/jbc.271.32.19428

S. Lim and W. Copeland, Differential Incorporation and Removal of Antiviral Deoxynucleotides by Human DNA Polymerase ??, Journal of Biological Chemistry, vol.276, issue.26, pp.23616-23623, 2001.
DOI : 10.1074/jbc.M101114200

A. Johnson, A. Ray, J. Hanes, Z. Suo, and J. Colacino, Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase, Journal of Biological Chemistry, vol.276, issue.44, pp.40847-40857, 2001.
DOI : 10.1074/jbc.M106743200

J. Arnold, S. Sharma, J. Feng, A. Ray, and E. Smidansky, Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides, PLoS Pathogens, vol.54, issue.11, p.1003030, 2012.
DOI : 10.1371/journal.ppat.1003030.s010

L. Coffey, Y. Beeharry, A. Borderia, H. Blanc, and M. Vignuzzi, Arbovirus high fidelity variant loses fitness in mosquitoes and mice, Proceedings of the National Academy of Sciences, vol.108, issue.38, pp.16038-16043, 2011.
DOI : 10.1073/pnas.1111650108
URL : https://hal.archives-ouvertes.fr/pasteur-00620624

M. Vignuzzi, E. Wendt, and R. Andino, Engineering attenuated virus vaccines by controlling replication fidelity, Nature Medicine, vol.7, issue.2, pp.154-161, 2008.
DOI : 10.1038/nm1726

J. Pfeiffer and K. Kirkegaard, A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity, Proceedings of the National Academy of Sciences, vol.100, issue.12, pp.7289-7294, 2003.
DOI : 10.1073/pnas.1232294100

D. Streeter, J. Witkowski, G. Khare, R. Sidwell, and R. Bauer, Mechanism of Action of 1-??-D-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole), A New Broad-Spectrum Antiviral Agent, Proceedings of the National Academy of Sciences, vol.70, issue.4, pp.1174-1178, 1973.
DOI : 10.1073/pnas.70.4.1174

S. Carter, T. Franklin, D. Jones, B. Leonard, and S. Mills, Mycophenolic Acid: an Anti-cancer Compound with Unusual Properties, Nature, vol.94, issue.5208, pp.848-850, 1969.
DOI : 10.1038/223848a0

S. Carr, E. Papp, J. Wu, and Y. Natsumeda, Characterization of human type I and type II IMP dehydrogenases, J Biol Chem, vol.268, pp.27286-27290, 1993.

T. Franklin and J. Cook, The inhibition of nucleic acid synthesis by mycophenolic acid, Biochemical Journal, vol.113, issue.3, pp.515-524, 1969.
DOI : 10.1042/bj1130515

R. Takhampunya, S. Ubol, H. Houng, C. Cameron, and R. Padmanabhan, Inhibition of dengue virus replication by mycophenolic acid and ribavirin, Journal of General Virology, vol.87, issue.7, pp.1947-1952, 2006.
DOI : 10.1099/vir.0.81655-0

E. Domingo, J. Sheldon, and C. Perales, Viral Quasispecies Evolution, Microbiology and Molecular Biology Reviews, vol.76, issue.2, pp.159-216, 2012.
DOI : 10.1128/MMBR.05023-11

K. Ibarra and J. Pfeiffer, Reduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug Resistance, Journal of Virology, vol.83, issue.9, pp.4538-4547, 2009.
DOI : 10.1128/JVI.02280-08

N. Shah, A. Sunderland, and V. Grdzelishvili, Cell Type Mediated Resistance of Vesicular Stomatitis Virus and Sendai Virus to Ribavirin, PLoS ONE, vol.329, issue.6, p.11265, 2010.
DOI : 10.1371/journal.pone.0011265.t002

J. Cinatl, B. Morgenstern, G. Bauer, P. Chandra, and H. Rabenau, Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus, The Lancet, vol.361, issue.9374, pp.2045-2046, 2003.
DOI : 10.1016/S0140-6736(03)13615-X

H. Moreno, H. Tejero, J. De-la-torre, E. Domingo, and V. Martin, Mutagenesis-Mediated Virus Extinction: Virus-Dependent Effect of Viral Load on Sensitivity to Lethal Defection, PLoS ONE, vol.264, issue.8, p.32550, 2012.
DOI : 10.1371/journal.pone.0032550.s005

R. Agudo, A. Arias, N. Pariente, C. Perales, and C. Escarmis, Molecular Characterization of a Dual Inhibitory and Mutagenic Activity of 5-Fluorouridine Triphosphate on Viral RNA Synthesis. Implications for Lethal Mutagenesis, Journal of Molecular Biology, vol.382, issue.3, pp.652-666, 2008.
DOI : 10.1016/j.jmb.2008.07.033

J. De-la-torre, Arenavirus extinction through lethal mutagenesis, Virus Research, vol.107, issue.2, pp.207-214, 2005.
DOI : 10.1016/j.virusres.2004.11.010

R. Agudo, A. Arias, and E. Domingo, 5-fluorouracil in lethal mutagenesis of foot-and-mouth disease virus, Future Medicinal Chemistry, vol.1, issue.3, pp.529-539, 2009.
DOI : 10.4155/fmc.09.26

J. Arnold, M. Vignuzzi, J. Stone, R. Andino, and C. Cameron, Remote Site Control of an Active Site Fidelity Checkpoint in a Viral RNA-dependent RNA Polymerase, Journal of Biological Chemistry, vol.280, issue.27, pp.25706-25716, 2005.
DOI : 10.1074/jbc.M503444200

P. Gong and O. Peersen, Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase, Proceedings of the National Academy of Sciences, vol.107, issue.52, pp.22505-22510, 2010.
DOI : 10.1073/pnas.1007626107

A. Thompson, R. Albertini, and O. Peersen, Stabilization of Poliovirus Polymerase by NTP Binding and Fingers???Thumb Interactions, Journal of Molecular Biology, vol.366, issue.5, pp.1459-1474, 2007.
DOI : 10.1016/j.jmb.2006.11.070

M. Prindle, M. Schmitt, F. Parmeggiani, and L. Loeb, A Substitution in the Fingers Domain of DNA Polymerase ?? Reduces Fidelity by Altering Nucleotide Discrimination in the Catalytic Site, Journal of Biological Chemistry, vol.288, issue.8, pp.5572-5580, 2013.
DOI : 10.1074/jbc.M112.436410

J. Graci, N. Gnadig, J. Galarraga, C. Castro, and M. Vignuzzi, Mutational Robustness of an RNA Virus Influences Sensitivity to Lethal Mutagenesis, Journal of Virology, vol.86, issue.5, pp.2869-2873, 2012.
DOI : 10.1128/JVI.05712-11
URL : https://hal.archives-ouvertes.fr/pasteur-00918204

M. Vignuzzi, J. Stone, J. Arnold, C. Cameron, and R. Andino, Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population, Nature, vol.77, issue.7074, pp.344-348, 2006.
DOI : 10.1038/nature04388

M. Denison, R. Graham, E. Donaldson, L. Eckerle, and R. Baric, Coronaviruses, RNA Biology, vol.70, issue.2, pp.270-279, 2011.
DOI : 10.1128/JVI.79.4.2346-2355.2005
URL : https://hal.archives-ouvertes.fr/pasteur-00918207

S. Mi, R. Durbin, H. Huang, C. Rice, and V. Stollar, Association of the sindbis virus RNA methyltransferase activity with the nonstructural protein nsP1, Virology, vol.170, issue.2, pp.385-391, 1989.
DOI : 10.1016/0042-6822(89)90429-7

L. Scheidel and V. Stollar, Mutations that confer resistance to mycophenolic acid and ribavirin on sindbis virus map to the nonstructural protein nsP1, Virology, vol.181, issue.2, pp.490-499, 1991.
DOI : 10.1016/0042-6822(91)90881-B

M. Manns, G. Foster, J. Rockstroh, S. Zeuzem, and F. Zoulim, The way forward in HCV treatment ??? finding the right path, Nature Reviews Drug Discovery, vol.46, issue.12, pp.991-1000, 2007.
DOI : 10.1038/nrd2411

K. Cummings, S. Lee, E. West, J. Cid-ruzafa, and S. Fein, Interferon and Ribavirin vs Interferon Alone in the Re-treatment of Chronic Hepatitis C Previously Nonresponsive to Interferon, JAMA, vol.285, issue.2, pp.193-199, 2001.
DOI : 10.1001/jama.285.2.193

G. Davis, R. Esteban-mur, V. Rustgi, J. Hoefs, and S. Gordon, Interferon Alfa-2b Alone or in Combination with Ribavirin for the Treatment of Relapse of Chronic Hepatitis C, New England Journal of Medicine, vol.339, issue.21, pp.1493-1499, 1998.
DOI : 10.1056/NEJM199811193392102

J. Mccormick, I. King, P. Webb, C. Scribner, and R. Craven, Lassa Fever, New England Journal of Medicine, vol.314, issue.1, pp.20-26, 1986.
DOI : 10.1056/NEJM198601023140104

C. Hall, E. Walsh, J. Hruska, R. Betts, and W. Hall, Ribavirin treatment of experimental respiratory syncytial viral infection. A controlled double-blind study in young adults, JAMA: The Journal of the American Medical Association, vol.249, issue.19, pp.2666-2670, 1983.
DOI : 10.1001/jama.249.19.2666

P. Wyde, Respiratory syncytial virus (RSV) disease and prospects for its control, Antiviral Research, vol.39, issue.2, pp.63-79, 1998.
DOI : 10.1016/S0166-3542(98)00029-1

M. Bouvet, C. Debarnot, I. Imbert, B. Selisko, and E. Snijder, In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation, PLoS Pathogens, vol.235, issue.4, p.1000863, 2010.
DOI : 10.1371/journal.ppat.1000863.s002

Y. Chen, H. Cai, J. Pan, N. Xiang, and P. Tien, Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase, Proceedings of the National Academy of Sciences, vol.106, issue.9, pp.3484-3489, 2009.
DOI : 10.1073/pnas.0808790106

Y. Chen, J. Tao, Y. Sun, A. Wu, and C. Su, Structure-function Analysis of SARS Coronavirus RNA Cap Guanine-N7 Methyltransferase, J Virol, pp.1000061-1000074, 1128.

J. Fortune, Y. Pavlov, C. Welch, E. Johansson, and P. Burgers, DNA Polymerase ??, Journal of Biological Chemistry, vol.280, issue.33, pp.29980-29987, 2005.
DOI : 10.1074/jbc.M505236200

R. Karthikeyan, E. Vonarx, A. Straffon, M. Simon, and G. Faye, Evidence from mutational specificity studies that yeast DNA polymerases ?? and ?? replicate different DNA strands at an intracellular replication fork, Journal of Molecular Biology, vol.299, issue.2, pp.405-419, 2000.
DOI : 10.1006/jmbi.2000.3744

L. Reha-krantz, S. Stocki, R. Nonay, E. Dimayuga, and L. Goodrich, DNA polymerization in the absence of exonucleolytic proofreading: in vivo and in vitro studies., Proceedings of the National Academy of Sciences, vol.88, issue.6, pp.2417-2421, 1991.
DOI : 10.1073/pnas.88.6.2417

A. Morrison and A. Sugino, The 3? ? 5? exonucleases of both DNA polymerases ? and ? participate in correcting errors of DNA replication in Saccharomyces cerevisiae, MGG Molecular & General Genetics, vol.60, issue.3, pp.289-296, 1994.
DOI : 10.1007/BF00280418

P. Shcherbakova, Y. Pavlov, O. Chilkova, I. Rogozin, and E. Johansson, Unique Error Signature of the Four-subunit Yeast DNA Polymerase ??, Journal of Biological Chemistry, vol.278, issue.44, pp.43770-43780, 2003.
DOI : 10.1074/jbc.M306893200

C. Perales, V. Martin, and E. Domingo, Lethal mutagenesis of viruses, Current Opinion in Virology, vol.1, issue.5, pp.419-422, 2011.
DOI : 10.1016/j.coviro.2011.09.001

R. Sidwell, J. Huffman, G. Khare, L. Allen, and J. Witkowski, Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1, Science, vol.2, issue.177, pp.4-7, 1972.

Y. Furuta, K. Takahashi, Y. Fukuda, M. Kuno, and T. Kamiyama, In Vitro and In Vivo Activities of Anti-Influenza Virus Compound T-705, Antimicrobial Agents and Chemotherapy, vol.46, issue.4, pp.977-981, 2002.
DOI : 10.1128/AAC.46.4.977-981.2002

T. Baranovich, S. Wong, J. Armstrong, H. Marjuki, and R. Webby, T-705 (Favipiravir) Induces Lethal Mutagenesis in Influenza A H1N1 Viruses In Vitro, Journal of Virology, vol.87, issue.7, pp.3741-3751, 2013.
DOI : 10.1128/JVI.02346-12

J. Pfeiffer and K. Kirkegaard, Increased Fidelity Reduces Poliovirus Fitness and Virulence under Selective Pressure in Mice, PLoS Pathogens, vol.78, issue.2, p.11, 2005.
DOI : 0027-8424(1981)078[4887:MCOPCA]2.0.CO;2