Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. - Institut Pasteur Access content directly
Journal Articles Journal of Virology Year : 2012

Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.

Abstract

The ability to extinguish a viral population of fixed reproductive capacity by causing small changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of population genetics theory. Here we show that coxsackievirus B3 (CVB3) exhibits reduced mutational robustness relative to poliovirus, manifesting in enhanced sensitivity of CVB3 to lethal mutagens that is dependent on the size of the viral population. We suggest that mutational robustness may be a useful measure of the sensitivity of a virus to lethal mutagenesis.

Domains

Virology
Fichier principal
Vignette du fichier
zjv2869.pdf (256.49 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

pasteur-00918204 , version 1 (13-12-2013)

Identifiers

Cite

Jason D Graci, Nina F Gnädig, Jessica E Galarraga, Christian Castro, Marco Vignuzzi, et al.. Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.. Journal of Virology, 2012, 86 (5), pp.2869-73. ⟨10.1128/JVI.05712-11⟩. ⟨pasteur-00918204⟩

Collections

PASTEUR CNRS
72 View
322 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More