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Journal articles
Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.
Abstract : The ability to extinguish a viral population of fixed reproductive capacity by causing small changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of population genetics theory. Here we show that coxsackievirus B3 (CVB3) exhibits reduced mutational robustness relative to poliovirus, manifesting in enhanced sensitivity of CVB3 to lethal mutagens that is dependent on the size of the viral population. We suggest that mutational robustness may be a useful measure of the sensitivity of a virus to lethal mutagenesis.
Cited literature [33 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-00918204
Contributor : Marco Vignuzzi Connect in order to contact the contributor
Submitted on : Friday, December 13, 2013 - 9:58:23 AM
Last modification on : Monday, January 13, 2020 - 5:08:10 PM
Long-term archiving on: : Tuesday, March 18, 2014 - 12:27:24 PM
Contributor : Marco Vignuzzi Connect in order to contact the contributor
Submitted on : Friday, December 13, 2013 - 9:58:23 AM
Last modification on : Monday, January 13, 2020 - 5:08:10 PM
Long-term archiving on: : Tuesday, March 18, 2014 - 12:27:24 PM
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