Characterizing the topology of protein beta-sheets by an axis.

Jean-Luc Jestin (1) , Bernard Caudron (2)

1 Département de Virologie - Department of Virology
2 Centre d'Informatique pour la Biologie

Beta-sheets and alpha-helices are the most frequent structural elements composing protein structures. Beta-sheets typically highlight complex curved and sequence-dependent surfaces of parallel and/or anti-parallel beta-strands. The topology of these curved surfaces are described in this work by a unique axis crossing all beta-sheet's strands. The distribution of the distances of the alpha carbons in each strand which are the closest to the axis is given. The frequency of the twenty amino acids along the axis is provided. Applications in the field of protein structure prediction are mentioned.

Domaines: Biologie structurale [q-bio.BM]

Jean-Luc Jestin, Bernard Caudron. Characterizing the topology of protein beta-sheets by an axis.. 2013. ⟨pasteur-00907789⟩