Propagation of Tau Misfolding from the Outside to the Inside of a Cell, Journal of Biological Chemistry, vol.284, issue.19, pp.12845-12852, 2009. ,
DOI : 10.1074/jbc.M808759200
Transmission and spreading of tauopathy in transgenic mouse brain, Nature Cell Biology, vol.8, issue.7, pp.909-913, 2009. ,
DOI : 10.1038/ncb1901
Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau, Scientific Reports, vol.421, p.700, 2012. ,
DOI : 10.1038/srep00700
URL : http://doi.org/10.1038/srep00700
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders, Nature Reviews Neuroscience, vol.4, issue.9, pp.663-672, 2007. ,
DOI : 10.1096/fj.04-3620rev
Association of missense and 5-splice-site mutations in tau with the inherited dementia FTDP-17, Nature, vol.393, issue.6686, pp.702-705, 1998. ,
DOI : 10.1038/31508
Tau Pathology in Two Dutch Families with Mutations in the Microtubule-Binding Region of Tau, The American Journal of Pathology, vol.153, issue.5, pp.1359-1363, 1998. ,
DOI : 10.1016/S0002-9440(10)65721-5
High Prevalence of Mutations in the Microtubule-Associated Protein Tau in a Population Study of Frontotemporal Dementia in the Netherlands, The American Journal of Human Genetics, vol.64, issue.2, pp.414-421, 1999. ,
DOI : 10.1086/302256
Mutations causing neurodegenerative tauopathies, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1739, issue.2-3, pp.240-250, 2005. ,
DOI : 10.1016/j.bbadis.2004.08.007
URL : http://doi.org/10.1016/j.bbadis.2004.08.007
Regulation of tau isoform expression and dementia, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1739, issue.2-3, pp.104-115, 2005. ,
DOI : 10.1016/j.bbadis.2004.08.009
The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts, Neurobiology of Disease, vol.25, issue.3, pp.561-570, 2007. ,
DOI : 10.1016/j.nbd.2006.10.018
Neuropathological stageing of Alzheimer-related changes, Acta Neuropathologica, vol.80, issue.4, pp.239-259, 1991. ,
DOI : 10.1007/BF00308809
Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson???s disease cases, Journal of Neural Transmission, vol.2006, issue.Suppl 4, pp.809-819, 2011. ,
DOI : 10.1007/s00702-010-0508-2
Trans-Synaptic Spread of Tau Pathology In Vivo, PLoS ONE, vol.25, issue.2, 2012. ,
DOI : 10.1371/journal.pone.0031302.g008
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease, Neuron, vol.73, issue.4, pp.685-697, 2012. ,
DOI : 10.1016/j.neuron.2011.11.033
Heat-shock protein 70 modulates toxic extracellular ??-synuclein oligomers and rescues trans-synaptic toxicity, The FASEB Journal, vol.25, issue.1, pp.326-336, 2011. ,
DOI : 10.1096/fj.10-164624
Seeding induced by ??-synuclein oligomers provides evidence for spreading of ??-synuclein pathology, Journal of Neurochemistry, vol.9, issue.Suppl. 2, pp.192-203, 2009. ,
DOI : 10.1111/j.1471-4159.2009.06324.x
Different Species of ??-Synuclein Oligomers Induce Calcium Influx and Seeding, Journal of Neuroscience, vol.27, issue.34, pp.9220-9232, 2007. ,
DOI : 10.1523/JNEUROSCI.2617-07.2007
Trans-cellular Propagation of Tau Aggregation by Fibrillar Species, Journal of Biological Chemistry, vol.287, issue.23, pp.19440-19451, 2012. ,
DOI : 10.1074/jbc.M112.346072
The Priori Diseases, Brain Pathology, vol.36, issue.Suppl. 1, pp.499-513, 1998. ,
DOI : 10.1111/j.1750-3639.1998.tb00171.x
Prions hijack tunnelling nanotubes for intercellular spread, Nature Cell Biology, vol.177, issue.3, pp.328-336, 2009. ,
DOI : 10.1038/nprot.2006.356
URL : https://hal.archives-ouvertes.fr/pasteur-00368712
Prions tunnel between cells, Nature Cell Biology, vol.180, issue.3, pp.235-236, 2009. ,
DOI : 10.1038/nrm2399
Cells release prions in association with exosomes, Proceedings of the National Academy of Sciences, vol.101, issue.26, pp.9683-9688, 2004. ,
DOI : 10.1073/pnas.0308413101
Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease, Journal of Biological Chemistry, vol.287, issue.6, pp.3842-3849, 2012. ,
DOI : 10.1074/jbc.M111.277061
Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells, Proceedings of the National Academy of Sciences, vol.108, issue.9, pp.3548-3553, 2011. ,
DOI : 10.1073/pnas.1017275108
Assembly-dependent endocytosis and clearance of extracellular a-synuclein, The International Journal of Biochemistry & Cell Biology, vol.40, issue.9, pp.1835-1849, 2008. ,
DOI : 10.1016/j.biocel.2008.01.017
Clearance and deposition of extracellular ??-synuclein aggregates in microglia, Biochemical and Biophysical Research Communications, vol.372, issue.3, pp.423-428, 2008. ,
DOI : 10.1016/j.bbrc.2008.05.045
Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates, Nature Cell Biology, vol.309, issue.2, pp.219-225, 2009. ,
DOI : 10.1016/S0092-8674(00)80514-0
URL : https://hal.archives-ouvertes.fr/hal-01183798
In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice, Journal of Neuroscience, vol.31, issue.37, pp.13110-13117, 2011. ,
DOI : 10.1523/JNEUROSCI.2569-11.2011
Preparation and Characterization of Neurotoxic Tau Oligomers, Biochemistry, vol.49, issue.47, pp.10039-10041, 2010. ,
DOI : 10.1021/bi1016233
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice, Molecular Neurodegeneration, vol.6, issue.1, p.39, 2011. ,
DOI : 10.1074/jbc.M605336200
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo, Autophagy, vol.3, issue.4, pp.609-622, 2012. ,
DOI : 10.1073/pnas.87.15.5827
Cryosectioning and immunolabeling, Nature Protocols, vol.82, issue.10, pp.2480-2491, 2007. ,
DOI : 10.1038/nprot.2007.365
Optimized survival of hippocampal neurons in B27-supplemented neurobasal?, a new serum-free medium combination, Journal of Neuroscience Research, vol.9, issue.5, pp.567-576, 1993. ,
DOI : 10.1002/jnr.490350513
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function, Science, vol.309, issue.5733, pp.476-481, 2005. ,
DOI : 10.1126/science.1113694
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau, Journal of Neuroscience Research, vol.85, issue.2, pp.128-132, 1997. ,
DOI : 10.1002/(SICI)1097-4547(19970415)48:2<128::AID-JNR5>3.0.CO;2-E
Tau aggregation is driven by a transition from random coil to beta sheet structure, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1739, issue.2-3, pp.158-166, 2005. ,
DOI : 10.1016/j.bbadis.2004.09.010
Purification of Recombinant Tau Protein and Preparation of Alzheimer-Paired Helical Filaments In Vitro, Methods Mol. Biol, vol.299, pp.35-51, 2005. ,
DOI : 10.1385/1-59259-874-9:035
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease, The FASEB Journal, vol.26, issue.5, pp.1946-1959, 2012. ,
DOI : 10.1096/fj.11-199851
Structural characterization of the core of the paired helical filament of Alzheimer disease., Proceedings of the National Academy of Sciences, vol.85, issue.13, pp.4884-4888, 1988. ,
DOI : 10.1073/pnas.85.13.4884
Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers, Journal of Biological Chemistry, vol.280, issue.17, pp.17294-17300, 2005. ,
DOI : 10.1074/jbc.M500997200
Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles, Journal of Biological Chemistry, vol.286, issue.17, pp.15317-15331, 2011. ,
DOI : 10.1074/jbc.M110.209296
A microfluidic culture platform for CNS axonal injury, regeneration and transport, Nature Methods, vol.20, issue.8, pp.599-605, 2005. ,
DOI : 10.1038/nmeth777
Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models, Neurobiology of Aging, vol.34, issue.1, pp.338-350, 2013. ,
DOI : 10.1016/j.neurobiolaging.2012.05.010
[33] Use of horseradish peroxidase and fluorescent dextrans to study fluid pinocytosis in leukocytes, Methods Enzymol, vol.108, pp.336-347, 1984. ,
DOI : 10.1016/S0076-6879(84)08100-3
Dynasore, a Cell-Permeable Inhibitor of Dynamin, Developmental Cell, vol.10, issue.6, pp.839-850, 2006. ,
DOI : 10.1016/j.devcel.2006.04.002
Discovery of a new 'dynasore', Nature Chemical Biology, vol.11, issue.7, pp.355-356, 2006. ,
DOI : 10.1038/nchembio0706-355
Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition, Cell, vol.146, issue.3, pp.471-484, 2011. ,
DOI : 10.1016/j.cell.2011.06.025
Detection of protease activity using a fluorescence-enhancement globular substrate, BioTechniques, vol.20, pp.286-291, 1996. ,
Three- and Four-repeat Tau Coassemble into Heterogeneous Filaments: AN IMPLICATION FOR ALZHEIMER DISEASE, Journal of Biological Chemistry, vol.285, issue.48, pp.37920-37926, 2010. ,
DOI : 10.1074/jbc.M110.185728
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments., Proceedings of the National Academy of Sciences, vol.92, issue.18, pp.8463-8467, 1995. ,
DOI : 10.1073/pnas.92.18.8463
Mechanism of amyloid plaque formation suggests an intracellular basis of A?? pathogenicity, Proceedings of the National Academy of Sciences, vol.107, issue.5, pp.1942-1947, 2010. ,
DOI : 10.1073/pnas.0904532106
Atomic structures of amyloid cross-?? spines reveal varied steric zippers, Nature, vol.234, issue.7143, pp.453-457, 2007. ,
DOI : 10.1038/nature05695
Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease, Nature, vol.86, issue.4863, pp.192-193, 1963. ,
DOI : 10.1038/197192b0
FILAMENTOUS AGGREGATES IN PICK'S DISEASE, PROGRESSIVE SUPRANUCLEAR PALSY, AND ALZHEIMER'S DISEASE SHARE ANTIGENIC DETERMINANTS WITH MICROTUBULE-ASSOCIATED PROTEIN, TAU, The Lancet, vol.328, issue.8517, p.1211, 1986. ,
DOI : 10.1016/S0140-6736(86)92212-9
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans, Nature, vol.383, issue.6600, pp.550-553, 1996. ,
DOI : 10.1038/383550a0
Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly, FEBS Letters, vol.8, issue.3, pp.207-210, 1998. ,
DOI : 10.1016/S0014-5793(98)01217-4
Free fatty acids stimulate the polymerization of Tau and amyloid peptides In vitro evidence for a common effector of pathogenesis in Alzheimer's disease, Am. J. Pathol, vol.150, pp.2181-2195, 1997. ,
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis, Science, vol.300, issue.5618, pp.486-489, 2003. ,
DOI : 10.1126/science.1079469
Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid ?? but Do Not Seed Fibril Formation, Journal of Biological Chemistry, vol.285, issue.9, pp.6071-6079, 2010. ,
DOI : 10.1074/jbc.M109.069542
Straight and paired helical filaments in Alzheimer disease have a common structural unit., Proceedings of the National Academy of Sciences, vol.88, issue.6, pp.2288-2292, 1991. ,
DOI : 10.1073/pnas.88.6.2288
Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease, Journal of Biological Chemistry, vol.286, issue.26, pp.23063-23076, 2011. ,
DOI : 10.1074/jbc.M111.237974
Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease, Neuroscience Research, vol.54, issue.3, pp.197-201, 2006. ,
DOI : 10.1016/j.neures.2005.11.009
Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: A possible general mechanism for familial ALS, Proceedings of the National Academy of Sciences, vol.104, issue.27, pp.11263-11267, 2007. ,
DOI : 10.1073/pnas.0704307104
A kinetic model for amyloid formation in the prion diseases: importance of seeding., Proceedings of the National Academy of Sciences, vol.90, issue.13, pp.5959-5963, 1993. ,
DOI : 10.1073/pnas.90.13.5959
Importance of low-oligomeric-weight species for prion propagation in the yeast prion system Sup35/Hsp104, Proceedings of the National Academy of Sciences, vol.100, issue.16, pp.9286-9291, 2003. ,
DOI : 10.1073/pnas.1233535100
Integrating molecular and network biology to decode endocytosis, Nature, vol.17, issue.7156, pp.883-888, 2007. ,
DOI : 10.1038/nature06031
Tat-mediated delivery of heterologous proteins into cells., Proceedings of the National Academy of Sciences, vol.91, issue.2, pp.664-668, 1994. ,
DOI : 10.1073/pnas.91.2.664
Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent, Journal of Biological Chemistry, vol.271, issue.30, pp.18188-18193, 1996. ,
DOI : 10.1074/jbc.271.30.18188
Exogenous ??-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death, Neuron, vol.72, issue.1, pp.57-71, 2011. ,
DOI : 10.1016/j.neuron.2011.08.033
Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction, Nature Reviews Neuroscience, vol.3, issue.11, pp.826-838, 2008. ,
DOI : 10.1038/nrn2499
Alzheimer???s pathogenesis: is there neuron-to-neuron propagation?, Acta Neuropathologica, vol.60, issue.5, pp.589-595, 2011. ,
DOI : 10.1007/s00401-011-0825-z
The pathological process underlying Alzheimer???s disease in individuals under thirty, Acta Neuropathologica, vol.24, issue.Suppl. 1, pp.171-181, 2011. ,
DOI : 10.1007/s00401-010-0789-4
Aggresomes, inclusion bodies and protein aggregation, Trends in Cell Biology, vol.10, issue.12, pp.524-530, 2000. ,
DOI : 10.1016/S0962-8924(00)01852-3