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Antibodies in HIV-1 vaccine development and therapy.

Abstract : Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope for a protective immunization. Renewed optimism in this area of research comes in part from the results of a recent vaccine trial and the use of single-cell antibody-cloning techniques that uncovered naturally arising, broad and potent HIV-1-neutralizing antibodies (bNAbs). These antibodies can protect against infection and suppress established HIV-1 infection in animal models. The finding that these antibodies develop in a fraction of infected individuals supports the idea that new approaches to vaccination might be developed by adapting the natural immune strategies or by structure-based immunogen design. Moreover, the success of passive immunotherapy in small-animal models suggests that bNAbs may become a valuable addition to the armamentarium of drugs that work against HIV-1.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00861957
Contributor : Hugo Mouquet <>
Submitted on : Saturday, September 14, 2013 - 11:15:55 AM
Last modification on : Friday, April 3, 2020 - 9:42:36 AM

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Florian Klein, Hugo Mouquet, Pia Dosenovic, Johannes F Scheid, Louise Scharf, et al.. Antibodies in HIV-1 vaccine development and therapy.. Science, American Association for the Advancement of Science, 2013, 341 (6151), pp.1199-204. ⟨10.1126/science.1241144⟩. ⟨pasteur-00861957⟩

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