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Journal articles
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3(+) regulatory T cells.
Wim Pierson
1, 2
Bénédicte Cauwe
1, 2
Antonia Policheni
3, 4
Susan M Schlenner
1, 2
Dean Franckaert
1, 2
Julien Berges
5
Stephanie Humblet-Baron
1, 2
Susann Schönefeldt
1, 2
Marco J Herold
3, 4
David Hildeman
6, 7
Andreas Strasser
3, 4
Philippe Bouillet
3, 4
Li-Fan Lu
8
Patrick Matthys
9
Antonio A Freitas
5
Rita J Luther
10
Casey T Weaver
10
James Dooley
1, 2
Daniel H D Gray
3, 4, *
Adrian Liston
1, 2, *
*
Corresponding author
Wim Pierson 1, 2
Author
Bénédicte Cauwe 1, 2
Author
Antonia Policheni 3, 4
Author
Susan M Schlenner 1, 2
Author
Dean Franckaert 1, 2
Author
Julien Berges 5
Author
Stephanie Humblet-Baron 1, 2
Author
Susann Schönefeldt 1, 2
Author
Marco J Herold 3, 4
Author
David Hildeman 6, 7
Author
Andreas Strasser 3, 4
Author
Philippe Bouillet 3, 4
Author
Casey T Weaver 10
Author
James Dooley 1, 2
Author
Daniel H D Gray 3, 4
Correspondent author
Adrian Liston 1, 2
Correspondent author
2
Department of Microbiology & Immunology (Belgium)
- KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven (Oude Markt 13 - bus 5005, 3000 Leuven - Belgium)
3
The Walter & Eliza Hall Institute of Medical Research (Australia)
- The Walter & Eliza Hall Institute (France)
4
Department of medical Biology (Australia)
- University of Melbourne (Parkville VIC 3010 - Australia)
5
Biologie des Populations Lymphocytaires (28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : URA1961 (France)
6
Children's Hospital Medical Center (United States)
7
Division of Immunobiology (Cincinnati, Ohio - United States)
- UC - University of Cincinnati (2600 Clifton Ave., Cincinnati OH, Ohio 45221 - United States)
8
Section of molecular Biology, Division of Biological Sciences (La Jolla, California, - United States)
- UC San Diego - University of California [San Diego] (9500 Gilman Dr., La Jolla, CA 92093 USA - United States)
- University of California (United States)
9
Laboratory of Immunobiology, Rega Institute (Leuven - Belgium)
- KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven (Oude Markt 13 - bus 5005, 3000 Leuven - Belgium)
10
Department of Pathology (Birmingham, Alabama - United States)
- UAB - University of Alabama at Birmingham [ Birmingham] (1720 2nd Ave S, Birmingham, AL 35233 - United States)
Abstract : Foxp3(+) regulatory T (Treg) cells are a crucial immunosuppressive population of CD4(+) T cells, yet the homeostatic processes and survival programs that maintain the Treg cell pool are poorly understood. Here we report that peripheral Treg cells markedly alter their proliferative and apoptotic rates to rapidly restore numerical deficit through an interleukin 2-dependent and costimulation-dependent process. By contrast, excess Treg cells are removed by attrition, dependent on the Bim-initiated Bak- and Bax-dependent intrinsic apoptotic pathway. The antiapoptotic proteins Bcl-xL and Bcl-2 were dispensable for survival of Treg cells, whereas Mcl-1 was critical for survival of Treg cells, and the loss of this antiapoptotic protein caused fatal autoimmunity. Together, these data define the active processes by which Treg cells maintain homeostasis via critical survival pathways.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00853340
Contributor : Marie-Christine Vougny <>
Submitted on : Thursday, August 22, 2013 - 2:23:00 PM
Last modification on : Monday, January 13, 2020 - 5:08:06 PM
Contributor : Marie-Christine Vougny <>
Submitted on : Thursday, August 22, 2013 - 2:23:00 PM
Last modification on : Monday, January 13, 2020 - 5:08:06 PM
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- HAL Id : pasteur-00853340, version 1
- DOI : 10.1038/ni.2649
- PUBMED : 23852275
Citation
Wim Pierson, Bénédicte Cauwe, Antonia Policheni, Susan M Schlenner, Dean Franckaert, et al.. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3(+) regulatory T cells.. Nature Immunology, Nature Publishing Group, 2013, 14 (9), pp.959-65. ⟨10.1038/ni.2649⟩. ⟨pasteur-00853340⟩
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