Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice

Nicolas Tchitchek (1) , Amie Eisfeld (2) , Jennifer Tisoncik-Go (1) , Laurence Josset (1) , Lisa Gralinski (3) , Christophe Bécavin (4) , Susan Tilton (5) , Bobbie-Jo Webb-Robertson (5) , Martin Ferris (3) , Allison Totura (3) , Chengjun Li (2) , Gabriele Neumann (2) , Thomas Metz (5) , Richard Smith (5) , Katrina Waters (5) , Ralph Baric (3) , Yoshihiro Kawaoka (2) , Michael Katze (1, 6)

1 Department of Microbiology
2 School of Veterinary Medicine, Department of Pathobiological Sciences
3 Department of Microbiology and Immunology, School of Medicine
4 UIBC - Interactions Bactéries-Cellules
5 Biological Sciences Division
6 Washington National Primate Research Center [Seattle]

Influenza infection causes respiratory disease that can lead to death. The complex interplay between virus-encoded and host-specific pathogenicity regulators - and the relative contributions of each toward viral pathogenicity - is not well-understood

Domains: Life Sciences [q-bio]; Biochemistry, Molecular Biology; Genomics [q-bio.GN]; Life Sciences [q-bio]; Quantitative Methods [q-bio.QM]; Computer Science [cs]; Bioinformatics [q-bio.QM]

Nicolas Tchitchek, Amie Eisfeld, Jennifer Tisoncik-Go, Laurence Josset, Lisa Gralinski, et al.. Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice. BMC Systems Biology, 2013, 7 (1), pp.69. ⟨10.1186/1752-0509-7-69⟩. ⟨pasteur-00850969⟩