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Journal articles
Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.
Abstract : We report the synthesis of 5'-modified thymidines (16, 18, 21, 23) and 5,5'-bis-substituted 2'-deoxyuridine analogues (30, 47) as inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt). These analogues were evaluated for their capacity to inhibit TMPKmt and solely two 5'-modified thymidines were found to possess moderate inhibitory activity. In addition, a feasibility study of protecting groups for the 5-CH(2)OH moiety of 2'-deoxyuridines is described that enables to introduce the desired 5'-modification.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00849837
Contributor : Hélène Munier-Lehmann Connect in order to contact the contributor
Submitted on : Thursday, August 1, 2013 - 11:28:55 AM
Last modification on : Wednesday, November 3, 2021 - 2:56:48 PM
Contributor : Hélène Munier-Lehmann Connect in order to contact the contributor
Submitted on : Thursday, August 1, 2013 - 11:28:55 AM
Last modification on : Wednesday, November 3, 2021 - 2:56:48 PM
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