L. Eidelman, D. Putterman, C. Putterman, and C. Sprung, The spectrum of septic encephalopathy. Definitions, etiologies, and mortalities, JAMA: The Journal of the American Medical Association, vol.275, issue.6, pp.470-473, 1996.
DOI : 10.1001/jama.275.6.470

C. Sprung, P. Peduzzi, C. Shatney, R. Schein, M. Wilson et al., Impact of encephalopathy on mortality in the sepsis syndrome, Critical Care Medicine, vol.18, issue.8, pp.801-806, 1990.
DOI : 10.1097/00003246-199008000-00001

E. Milbrandt and D. Angus, Potential mechanisms and markers of critical illness-associated cognitive dysfunction, Current Opinion in Critical Care, vol.11, issue.4, pp.355-359, 2005.
DOI : 10.1097/01.ccx.0000170508.63067.04

S. Jaber, G. Chanques, C. Altairac, M. Sebbane, C. Vergne et al., A Prospective Study of Agitation in a Medical-Surgical ICU, Chest, vol.128, issue.4, pp.2749-2757, 2005.
DOI : 10.1378/chest.128.4.2749

A. Heymann, M. Sander, D. Krahne, M. Deja, S. Weber-carstens et al., Hyperactive Delirium and Blood Glucose Control in Critically Ill Patients, Journal of International Medical Research, vol.51, issue.5, pp.666-677, 2007.
DOI : 10.1016/0196-6553(88)90053-3

E. Ely, S. Inouye, G. Bernard, S. Gordon, J. Francis et al., Delirium in Mechanically Ventilated Patients, JAMA, vol.286, issue.21, pp.2703-2710, 2001.
DOI : 10.1001/jama.286.21.2703

E. Ely, A. Shintani, B. Truman, T. Speroff, S. Gordon et al., Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit, JAMA, vol.291, issue.14, pp.1753-1762, 2004.
DOI : 10.1001/jama.291.14.1753

K. Tracey, The inflammatory reflex, Nature, vol.2, issue.6917, pp.853-859, 2002.
DOI : 10.1016/S0166-4328(99)00191-6

T. Sharshar and D. Annane, Endocrine effects of vasopressin in critically ill patients, Best Practice & Research Clinical Anaesthesiology, vol.22, issue.2, pp.265-273, 2008.
DOI : 10.1016/j.bpa.2008.02.005

D. Stellwagen and R. Malenka, Synaptic scaling mediated by glial TNF-??, Nature, vol.37, issue.7087, pp.1054-1059, 2006.
DOI : 10.1038/nature04671

N. Terrando, C. Monaco, D. Ma, B. Foxwell, M. Feldmann et al., Tumor necrosis factor-?? triggers a cytokine cascade yielding postoperative cognitive decline, Proceedings of the National Academy of Sciences, vol.107, issue.47, pp.20518-20522, 2010.
DOI : 10.1073/pnas.1014557107

N. Terrando, R. Fidalgo, A. Vizcaychipi, M. Cibelli, M. Ma et al., The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction, Critical Care, vol.14, issue.3, p.88, 2010.
DOI : 10.1186/cc9019

S. Chavan, P. Huerta, S. Robbiati, S. Valdes-ferrer, M. Ochani et al., HMGB1 mediates cognitive impairment in sepsis survivors, Mol Med, vol.18, pp.930-937, 2012.

W. Van-gool, D. Van-de-beek, and P. Eikelenboom, Systemic infection and delirium: when cytokines and acetylcholine collide, The Lancet, vol.375, issue.9716, pp.773-775, 2010.
DOI : 10.1016/S0140-6736(09)61158-2

C. Henry, Y. Huang, A. Wynne, and J. Godbout, Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1?? and anti-inflammatory IL-10 cytokines, Brain, Behavior, and Immunity, vol.23, issue.3, pp.309-317, 2009.
DOI : 10.1016/j.bbi.2008.09.002

J. Hannestad, J. Gallezot, T. Schafbauer, K. Lim, T. Kloczynski et al., Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates, NeuroImage, vol.63, issue.1, pp.232-239, 2012.
DOI : 10.1016/j.neuroimage.2012.06.055

J. Chen, J. Buchanan, N. Sparkman, J. Godbout, G. Freund et al., Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system, Brain, Behavior, and Immunity, vol.22, issue.3, pp.301-311, 2008.
DOI : 10.1016/j.bbi.2007.08.014

R. Barrientos, E. Higgins, J. Biedenkapp, D. Sprunger, K. Wright-hardesty et al., Peripheral infection and aging interact to impair hippocampal memory consolidation, Neurobiology of Aging, vol.27, issue.5, pp.723-732, 2006.
DOI : 10.1016/j.neurobiolaging.2005.03.010

Y. Imamura, H. Wang, N. Matsumoto, T. Muroya, J. Shimazaki et al., Interleukin-1?? causes long-term potentiation deficiency in a mouse model of septic encephalopathy, Neuroscience, vol.187, pp.63-69, 2011.
DOI : 10.1016/j.neuroscience.2011.04.063

M. Cibelli, A. Fidalgo, N. Terrando, D. Ma, C. Monaco et al., Role of interleukin-1?? in postoperative cognitive dysfunction, Annals of Neurology, vol.410, issue.3, pp.360-368, 2010.
DOI : 10.1002/ana.22082

A. Semmler, T. Okulla, M. Sastre, L. Dumitrescu-ozimek, and M. Heneka, Systemic inflammation induces apoptosis with variable vulnerability of different brain regions, Journal of Chemical Neuroanatomy, vol.30, issue.2-3, pp.144-157, 2005.
DOI : 10.1016/j.jchemneu.2005.07.003

A. Semmler, C. Frisch, T. Debeir, M. Ramanathan, T. Okulla et al., Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model, Experimental Neurology, vol.204, issue.2, pp.733-740, 2007.
DOI : 10.1016/j.expneurol.2007.01.003

M. Weberpals, M. Hermes, S. Hermann, M. Kummer, D. Terwel et al., NOS2 Gene Deficiency Protects from Sepsis-Induced Long-Term Cognitive Deficits, Journal of Neuroscience, vol.29, issue.45, pp.14177-14184, 2009.
DOI : 10.1523/JNEUROSCI.3238-09.2009

A. Semmler, C. Widmann, T. Okulla, H. Urbach, M. Kaiser et al., Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors, Journal of Neurology, Neurosurgery & Psychiatry, vol.84, issue.1, pp.62-69, 2013.
DOI : 10.1136/jnnp-2012-302883

O. Handa, J. Stephen, and G. Cepinskas, Role of endothelial nitric oxide synthase-derived nitric oxide in activation and dysfunction of cerebrovascular endothelial cells during early onsets of sepsis, AJP: Heart and Circulatory Physiology, vol.295, issue.4, pp.1712-1719, 2008.
DOI : 10.1152/ajpheart.00476.2008

F. Taccone, D. Castanares-zapatero, D. Peres-bota, J. Vincent, J. Berre et al., Cerebral Autoregulation is Influenced by Carbon Dioxide Levels in Patients with Septic Shock, Neurocritical Care, vol.36, issue.Suppl 1, pp.35-42, 2010.
DOI : 10.1007/s12028-009-9289-6

J. Alexander, A. Jacob, P. Cunningham, L. Hensley, and R. Quigg, TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1, Neurochemistry International, vol.52, issue.3, pp.447-456, 2008.
DOI : 10.1016/j.neuint.2007.08.006

T. Sharshar, R. Carlier, F. Bernard, C. Guidoux, J. Brouland et al., Brain lesions in septic shock: a??magnetic resonance imaging study, Intensive Care Medicine, vol.30, issue.5, pp.798-806, 2007.
DOI : 10.1007/s00134-007-0598-y

J. Fugate, D. Claassen, H. Cloft, D. Kallmes, O. Kozak et al., Posterior Reversible Encephalopathy Syndrome: Associated Clinical and Radiologic Findings, Mayo Clinic Proceedings, vol.85, issue.5, pp.427-432, 2010.
DOI : 10.4065/mcp.2009.0590
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861971

F. Bozza, P. Garteiser, M. Oliveira, S. Doblas, R. Cranford et al., Sepsis-Associated Encephalopathy: A Magnetic Resonance Imaging and Spectroscopy Study, Journal of Cerebral Blood Flow & Metabolism, vol.220, issue.2, pp.440-448, 2010.
DOI : 10.1016/j.pneurobio.2006.12.003

P. Pandharipande, A. Morandi, J. Adams, T. Girard, J. Thompson et al., Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients, Intensive Care Medicine, vol.46, issue.Pt 5, pp.1886-1892, 2009.
DOI : 10.1007/s00134-009-1573-6

A. Wilson, J. Morandi, A. Girard, T. Thompson, J. Boomershine et al., The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*, Critical Care Medicine, vol.40, issue.3, pp.835-841, 2012.
DOI : 10.1097/CCM.0b013e318236f62d

T. Sharshar, D. Annane, G. De-la-grandmaison, J. Brouland, N. Hopkinson et al., The Neuropathology of Septic Shock, Brain Pathology, vol.28, issue.1, pp.21-33, 2004.
DOI : 10.1111/j.1750-3639.2004.tb00494.x

T. Sharshar, F. Gray, G. Lorin-de-la-grandmaison, N. Hopkinson, E. Ross et al., Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock, The Lancet, vol.362, issue.9398, pp.1799-1805, 2003.
DOI : 10.1016/S0140-6736(03)14899-4

D. Pfister, M. Siegemund, S. Dell-kuster, P. Smielewski, S. Ruegg et al., Cerebral perfusion in sepsis-associated delirium, Critical Care, vol.12, issue.3, p.63, 2008.
DOI : 10.1186/cc6891

T. Hshieh, T. Fong, E. Marcantonio, and S. Inouye, Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.63, issue.7, pp.764-772, 2008.
DOI : 10.1093/gerona/63.7.764

A. Jansson, K. Olin, T. Yoshitake, B. Hagman, M. Herrington et al., Effects of isoflurane on prefrontal acetylcholine release and hypothalamic Fos response in young adult and aged rats, Experimental Neurology, vol.190, issue.2, pp.535-543, 2004.
DOI : 10.1016/j.expneurol.2004.08.027

R. Field, A. Gossen, and C. Cunningham, Prior Pathology in the Basal Forebrain Cholinergic System Predisposes to Inflammation-Induced Working Memory Deficits: Reconciling Inflammatory and Cholinergic Hypotheses of Delirium, Journal of Neuroscience, vol.32, issue.18, pp.6288-6294, 2012.
DOI : 10.1523/JNEUROSCI.4673-11.2012

Y. Kadoi and S. Saito, An alteration in the gamma-aminobutyric acid receptor system in experimentally induced septic shock in rats, Critical Care Medicine, vol.24, issue.2, pp.298-305, 1996.
DOI : 10.1097/00003246-199602000-00020

V. Pavlov, M. Ochani, M. Gallowitsch-puerta, K. Ochani, J. Huston et al., Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia, Proceedings of the National Academy of Sciences, vol.103, issue.13, pp.5219-5223, 2006.
DOI : 10.1073/pnas.0600506103

T. Basler, A. Meier-hellmann, D. Bredle, and K. Reinhart, Amino acid imbalance early in septic encephalopathy, Intensive Care Medicine, vol.28, issue.3, pp.293-298, 2002.
DOI : 10.1007/s00134-002-1217-6

M. Van-eijk, K. Roes, M. Honing, M. Kuiper, A. Karakus et al., Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial, The Lancet, vol.376, issue.9755, pp.1829-1837, 2010.
DOI : 10.1016/S0140-6736(10)61855-7

P. Pandharipande, A. Shintani, J. Peterson, B. Pun, G. Wilkinson et al., Lorazepam Is an Independent Risk Factor for Transitioning to Delirium in Intensive Care Unit Patients, Anesthesiology, vol.104, issue.1, pp.21-26, 2006.
DOI : 10.1097/00000542-200601000-00005

P. Pandharipande, R. Sanders, T. Girard, S. Mcgrane, J. Thompson et al., Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial, Critical Care, vol.14, issue.2, p.38, 2010.
DOI : 10.1186/cc8916

P. Pandharipande, B. Pun, D. Herr, M. Maze, T. Girard et al., Effect of Sedation With Dexmedetomidine vs Lorazepam on Acute Brain Dysfunction in Mechanically Ventilated Patients, JAMA, vol.298, issue.22, pp.2644-2653, 2007.
DOI : 10.1001/jama.298.22.2644

S. Jakob, E. Ruokonen, R. Grounds, T. Sarapohja, C. Garratt et al., Dexmedetomidine vs Midazolam or Propofol for Sedation During Prolonged Mechanical Ventilation, JAMA, vol.307, issue.11, pp.1151-1160, 2012.
DOI : 10.1001/jama.2012.304

S. Dahmani, D. Rouelle, P. Gressens, and J. Mantz, Effects of Dexmedetomidine on Hippocampal Focal Adhesion Kinase Tyrosine Phosphorylation in Physiologic and Ischemic Conditions, Anesthesiology, vol.103, issue.5, pp.969-977, 2005.
DOI : 10.1097/00000542-200511000-00011

S. Dahmani, D. Rouelle, P. Gressens, and J. Mantz, Characterization of the Postconditioning Effect of Dexmedetomidine in Mouse Organotypic Hippocampal Slice Cultures Exposed to Oxygen and Glucose Deprivation, Anesthesiology, vol.112, issue.2, pp.373-383, 2010.
DOI : 10.1097/ALN.0b013e3181ca6982

V. Degos, T. Charpentier, V. Chhor, O. Brissaud, S. Lebon et al., Neuroprotective Effects of Dexmedetomidine against Glutamate Agonist-induced Neuronal Cell Death Are Related to Increased Astrocyte Brain-derived Neurotrophic Factor Expression, Anesthesiology, vol.118, issue.5, pp.1123-1132, 2013.
DOI : 10.1097/ALN.0b013e318286cf36

T. Barichello, J. Fortunato, A. Vitali, G. Feier, A. Reinke et al., Oxidative variables in the rat brain after sepsis induced by cecal ligation and perforation, Critical Care Medicine, vol.34, issue.3, pp.886-889, 2006.
DOI : 10.1097/01.CCM.0000201880.50116.12

T. Barichello, R. Machado, L. Constantino, S. Valvassori, G. Reus et al., Antioxidant treatment prevented late memory impairment in an animal model of sepsis*, Critical Care Medicine, vol.35, issue.9, pp.2186-2190, 2007.
DOI : 10.1097/01.CCM.0000281452.60683.96

C. Comim, T. Barichello, D. Grandgirard, F. Dal-pizzol, J. Quevedo et al., Caspase-3 Mediates In Part Hippocampal Apoptosis in Sepsis, Molecular Neurobiology, vol.2, issue.1, pp.39-48, 2013.
DOI : 10.1007/s12035-012-8354-x

A. Polito, J. Brouland, R. Porcher, R. Sonneville, S. Siami et al., Hyperglycaemia and apoptosis of microglial cells in human septic shock, Critical Care, vol.15, issue.3, p.131, 2011.
DOI : 10.1001/jama.275.6.470
URL : https://hal.archives-ouvertes.fr/pasteur-00629084

S. Mcgrane, T. Girard, J. Thompson, A. Shintani, A. Woodworth et al., Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients, Crit Care Crit Care, vol.15, issue.15, p.297, 2011.

R. Sonneville, H. Hertog, F. Guiza, J. Gunst, I. Derese et al., Impact of Hyperglycemia on Neuropathological Alterations during Critical Illness, The Journal of Clinical Endocrinology & Metabolism, vol.97, issue.6, pp.2113-2123, 2012.
DOI : 10.1210/jc.2011-2971

R. Hopkins, M. Suchyta, G. Snow, A. Jephson, L. Weaver et al., Blood glucose dysregulation and cognitive outcome in ARDS survivors, Brain Injury, vol.9, issue.12, pp.1478-1484, 2010.
DOI : 10.1212/WNL.52.2.280

M. Mikkelsen, J. Christie, P. Lanken, R. Biester, B. Thompson et al., The Adult Respiratory Distress Syndrome Cognitive Outcomes Study, American Journal of Respiratory and Critical Care Medicine, vol.185, issue.12, pp.1307-1322, 2012.
DOI : 10.1164/rccm.201111-2025OC

D. Janz, T. Abel, J. Jackson, M. Gunther, S. Heckers et al., Brain autopsy findings in intensive care unit patients previously suffering from delirium: A pilot study, Journal of Critical Care, vol.25, issue.3, pp.25-537, 2010.
DOI : 10.1016/j.jcrc.2010.05.004

T. Girard, J. Jackson, P. Pandharipande, B. Pun, J. Thompson et al., Delirium as a predictor of long-term cognitive impairment in survivors of critical illness, Critical Care Medicine, vol.38, issue.7, pp.1513-1520, 2010.
DOI : 10.1097/CCM.0b013e3181e47be1

T. Sharshar, R. Porcher, S. Siami, B. Rohaut, J. Bailly-salin et al., Brainstem responses can predict death and delirium in sedated patients in intensive care unit*, Critical Care Medicine, vol.39, issue.8, pp.1960-1967, 2011.
DOI : 10.1097/CCM.0b013e31821b843b

K. Engelhard, C. Werner, E. Eberspacher, M. Bachl, M. Blobner et al., The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats, Anesth Analg, vol.96, pp.524-531, 2003.

D. Annane, F. Trabold, T. Sharshar, I. Jarrin, A. Blanc et al., Inappropriate Sympathetic Activation at Onset of Septic Shock, American Journal of Respiratory and Critical Care Medicine, vol.160, issue.2, pp.458-465, 1999.
DOI : 10.1164/ajrccm.160.2.9810073

E. Iacobone, J. Bailly-salin, A. Polito, D. Friedman, R. Stevens et al., Sepsis-associated encephalopathy and its differential diagnosis, Critical Care Medicine, vol.37, pp.331-336, 2009.
DOI : 10.1097/CCM.0b013e3181b6ed58

N. Bergeron, M. Dubois, M. Dumont, S. Dial, and Y. Skrobik, Intensive Care Delirium Screening Checklist: evaluation of a new screening tool, Intensive Care Medicine, vol.27, issue.5, pp.859-64, 2001.
DOI : 10.1007/s001340100909

O. Piazza, E. Russo, S. Cotena, G. Esposito, and R. Tufano, Elevated S100B levels do not correlate with the severity of encephalopathy during sepsis, British Journal of Anaesthesia, vol.99, issue.4, pp.518-521, 2007.
DOI : 10.1093/bja/aem201

D. Nguyen, H. Spapen, F. Su, J. Schiettecatte, L. Shi et al., Elevated serum levels of S-100?? protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock*, Critical Care Medicine, vol.34, issue.7, pp.1967-1974, 2006.
DOI : 10.1097/01.CCM.0000217218.51381.49

W. Bartynski, J. Boardman, Z. Zeigler, R. Shadduck, and J. Lister, Posterior reversible encephalopathy syndrome in infection, sepsis, and shock, AJNR Am J Neuroradiol, vol.27, pp.2179-2190, 2006.

A. Morandi, B. Rogers, M. Gunther, K. Merkle, P. Pandharipande et al., The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging, Critical Care Medicine, vol.40, issue.7, pp.2182-2189, 2012.
DOI : 10.1097/CCM.0b013e318250acdc

M. Gunther, A. Morandi, E. Krauskopf, P. Pandharipande, T. Girard et al., The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors, Critical Care Medicine, vol.40, issue.7, pp.2022-2032, 2012.
DOI : 10.1097/CCM.0b013e318250acc0

M. Oddo, E. Carrera, J. Claassen, S. Mayer, and L. Hirsch, Continuous electroencephalography in the medical intensive care unit*, Critical Care Medicine, vol.37, issue.6, pp.2051-2056, 2009.
DOI : 10.1097/CCM.0b013e3181a00604

B. Foreman, J. Claassen, A. Khaled, K. Jirsch, J. Alschuler et al., Generalized periodic discharges in the critically ill: A case-control study of 200 patients, Neurology, vol.79, issue.19, pp.1951-1960, 2012.
DOI : 10.1212/WNL.0b013e3182735cd7

P. Watson, A. Shintani, R. Tyson, P. Pandharipande, B. Pun et al., Presence of electroencephalogram burst suppression in sedated, critically ill patients is associated with increased mortality, Critical Care Medicine, vol.36, issue.12, pp.3171-3177, 2008.
DOI : 10.1097/CCM.0b013e318186b9ce

G. Young, C. Bolton, Y. Archibald, T. Austin, and G. Wells, The Electroencephalogram in Sepsis-Associated Encephalopathy, Journal of Clinical Neurophysiology, vol.9, issue.1, pp.145-152, 1992.
DOI : 10.1097/00004691-199201000-00016

C. Ong, E. Gilmore, J. Claassen, B. Foreman, and S. Mayer, Impact of Prolonged Periodic Epileptiform Discharges on Coma Prognosis, Neurocritical Care, vol.28, issue.4, pp.39-44, 2012.
DOI : 10.1007/s12028-012-9728-7

D. Awissi, G. Lebrun, D. Coursin, R. Riker, and Y. Skrobik, Alcohol withdrawal and delirium tremens in the critically ill: a systematic review and commentary, Intensive Care Medicine, vol.53, issue.1, pp.16-30, 2013.
DOI : 10.1007/s00134-012-2758-y

G. Sechi and A. Serra, Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management, The Lancet Neurology, vol.6, issue.5, pp.442-455, 2007.
DOI : 10.1016/S1474-4422(07)70104-7

O. Lucidarme, A. Seguin, C. Daubin, M. Ramakers, N. Terzi et al., Nicotine withdrawal and agitation in ventilated critically ill patients, Critical Care, vol.14, issue.2, p.58, 2010.
DOI : 10.1186/cc8954

I. Zaal, C. Spruyt, L. Peelen, M. Van-eijk, R. Wientjes et al., Intensive care unit environment may affect the course of delirium, Intensive Care Medicine, vol.37, issue.3, pp.481-488, 2012.
DOI : 10.1007/s00134-012-2726-6

J. Mcpherson, C. Wagner, L. Boehm, J. Hall, D. Johnson et al., Delirium in the Cardiovascular ICU, Critical Care Medicine, vol.41, issue.2, pp.405-413, 2012.
DOI : 10.1097/CCM.0b013e31826ab49b

R. Sonneville, M. Mirabel, D. Hajage, F. Tubach, P. Vignon et al., Neurologic complications and outcomes of infective endocarditis in critically ill patients: The ENDOcardite en REAnimation prospective multicenter study*, Critical Care Medicine, vol.39, issue.6, pp.1474-1481, 2011.
DOI : 10.1097/CCM.0b013e3182120b41

I. Klein, B. Iung, J. Labreuche, A. Hess, M. Wolff et al., Cerebral Microbleeds Are Frequent in Infective Endocarditis, Stroke, vol.40, issue.11, pp.3461-3465, 2009.
DOI : 10.1161/STROKEAHA.109.562546

M. Pisani, S. Kong, S. Kasl, T. Murphy, and K. Araujo, Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population, American Journal of Respiratory and Critical Care Medicine, vol.180, issue.11, pp.1092-1097, 2009.
DOI : 10.1164/rccm.200904-0537OC

E. Milbrandt, S. Deppen, P. Harrison, A. Shintani, T. Speroff et al., Costs associated with delirium in mechanically ventilated patients*, Critical Care Medicine, vol.32, issue.4, pp.955-962, 2004.
DOI : 10.1097/01.CCM.0000119429.16055.92

T. Iwashyna, E. Ely, D. Smith, and K. Langa, Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis, JAMA, vol.304, issue.16, pp.1787-1794, 2010.
DOI : 10.1001/jama.2010.1553

R. Hopkins and M. Herridge, Quality of Life, Emotional Abnormalities, and Cognitive Dysfunction in Survivors of Acute Lung Injury/Acute Respiratory Distress Syndrome, Clinics in Chest Medicine, vol.27, issue.4, pp.679-689, 2006.
DOI : 10.1016/j.ccm.2006.06.003

R. Hopkins and J. Jackson, Assessing neurocognitive outcomes after critical illness: are delirium and long-term cognitive impairments related?, Current Opinion in Critical Care, vol.12, issue.5, pp.388-394, 2006.
DOI : 10.1097/01.ccx.0000244115.24000.f5

R. Hopkins and J. Jackson, Short- and Long-Term Cognitive Outcomes in Intensive Care Unit Survivors, Clinics in Chest Medicine, vol.30, issue.1, pp.143-153, 2009.
DOI : 10.1016/j.ccm.2008.11.001

K. Boer, O. Van-ruler, A. Van-emmerik, M. Sprangers, S. De-rooij et al., Factors associated with posttraumatic stress symptoms in a??prospective cohort of patients after abdominal sepsis: a??nomogram, Intensive Care Medicine, vol.51, issue.4, pp.664-674, 2008.
DOI : 10.1007/s00134-007-0941-3

T. Girard, P. Pandharipande, and E. Ely, Delirium in the intensive care unit, Critical Care, vol.12, issue.Suppl 3, p.3, 2008.
DOI : 10.1097/01.CCM.0000150743.16005.9A

H. Spapen, D. Nguyen, J. Troubleyn, L. Huyghens, and J. Schiettecatte, Drotrecogin alfa (activated) may attenuate severe sepsis-associated encephalopathy in clinical septic shock, Critical Care, vol.14, issue.2, p.54, 2010.
DOI : 10.1186/cc8947

G. Schelling, B. Roozendaal, T. Krauseneck, M. Schmoelz, D. D. Briegel et al., Efficacy of Hydrocortisone in Preventing Posttraumatic Stress Disorder Following Critical Illness and Major Surgery, Annals of the New York Academy of Sciences, vol.10, issue.1, pp.46-53, 2006.
DOI : 10.1176/appi.ajp.161.8.1488

S. Ouimet, B. Kavanagh, S. Gottfried, and Y. Skrobik, Incidence, risk factors and consequences of ICU delirium, Intensive Care Medicine, vol.9, issue.Suppl A, pp.66-73, 2007.
DOI : 10.1007/s00134-006-0399-8

J. Kress, A. Pohlman, O. Connor, M. Hall, and J. , Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation, New England Journal of Medicine, vol.342, issue.20, pp.1471-1477, 2000.
DOI : 10.1056/NEJM200005183422002

T. Girard, J. Kress, B. Fuchs, J. Thomason, W. Schweickert et al., Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial, The Lancet, vol.371, issue.9607, pp.126-134, 2008.
DOI : 10.1016/S0140-6736(08)60105-1

R. Riker, Y. Shehabi, P. Bokesch, D. Ceraso, W. Wisemandle et al., Dexmedetomidine vs Midazolam for Sedation of Critically Ill Patients<subtitle>A Randomized Trial</subtitle>, JAMA, vol.301, issue.5, pp.489-499, 2009.
DOI : 10.1001/jama.2009.56

J. Payen, J. Bosson, G. Chanques, J. Mantz, and J. Labarere, Pain Assessment Is Associated with Decreased Duration of Mechanical Ventilation in the Intensive Care Unit, Anesthesiology, vol.111, issue.6, pp.1308-1316, 2009.
DOI : 10.1097/ALN.0b013e3181c0d4f0
URL : https://hal.archives-ouvertes.fr/hal-00453688

D. Awissi, C. Begin, J. Moisan, and J. Lachaine, I-SAVE Study: Impact of Sedation, Analgesia, and Delirium Protocols Evaluated in the Intensive Care Unit: An Economic Evaluation, Annals of Pharmacotherapy, vol.96, issue.1, pp.21-28, 2012.
DOI : 10.1097/CCM.0B013E3181544248

J. Woods, L. Mion, J. Connor, F. Viray, L. Jahan et al., Severe agitation among ventilated medical intensive care unit patients: frequency, characteristics and outcomes, Intensive Care Medicine, vol.30, issue.6, pp.1066-1072, 2004.
DOI : 10.1007/s00134-004-2193-9

S. Inouye, S. Bogardus, . Jr, P. Charpentier, L. Leo-summers et al., A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients, New England Journal of Medicine, vol.340, issue.9, pp.669-676, 1999.
DOI : 10.1056/NEJM199903043400901

S. Micek, N. Anand, B. Laible, W. Shannon, and M. Kollef, Delirium as detected by the CAM-ICU predicts restraint use among mechanically ventilated medical patients*, Critical Care Medicine, vol.33, issue.6, pp.1260-1265, 2005.
DOI : 10.1097/01.CCM.0000164540.58515.BF

W. Schweickert, M. Pohlman, A. Pohlman, C. Nigos, A. Pawlik et al., Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial, The Lancet, vol.373, issue.9678, pp.1874-1882, 2009.
DOI : 10.1016/S0140-6736(09)60658-9

Y. Kadoi and F. Goto, Selective Inducible Nitric Oxide Inhibition Can Restore Hemodynamics, but Does Not Improve Neurological Dysfunction in Experimentally-Induced Septic Shock in Rats, Anesthesia & Analgesia, vol.99, issue.1, pp.212-220, 2004.
DOI : 10.1213/01.ANE.0000118111.94913.22

F. Esen, T. Erdem, D. Aktan, M. Orhan, M. Kaya et al., Effect of magnesium sulfate administration on blood?brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study, Critical Care, vol.9, issue.1, pp.18-23, 2005.
DOI : 10.1186/cc3004

H. Toklu, M. Uysal, L. Kabasakal, S. Sirvanci, F. Ercan et al., The Effects of Riluzole on Neurological, Brain Biochemical, and Histological Changes in Early and Late Term of Sepsis in Rats, Journal of Surgical Research, vol.152, issue.2, pp.238-248, 2009.
DOI : 10.1016/j.jss.2008.03.013

S. Avtan, M. Kaya, N. Orhan, A. Arslan, N. Arican et al., The effects of hyperbaric oxygen therapy on blood???brain barrier permeability in septic rats, Brain Research, vol.1412, pp.63-72, 2011.
DOI : 10.1016/j.brainres.2011.07.020

M. Wratten, Therapeutic approaches to reduce systemic inflammation in septic-associated neurologic complications, European Journal of Anaesthesiology, vol.25, issue.Supplement 42, pp.1-7, 2008.
DOI : 10.1017/S0265021507003444

F. Esen, E. Senturk, P. Ozcan, B. Ahishali, N. Arican et al., Intravenous immunoglobulins prevent the breakdown of the blood-brain barrier in experimentally induced sepsis, Critical Care Medicine, vol.40, issue.4, pp.1214-1220, 2012.
DOI : 10.1097/CCM.0b013e31823779ca