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Journal articles
Quorum Sensing Contributes to Activated IgM-Secreting B Cell Homeostasis.
Abstract : Maintenance of plasma IgM levels is critical for immune system function and homeostasis in humans and mice. However, the mechanisms that control homeostasis of the activated IgM-secreting B cells are unknown. After adoptive transfer into immune-deficient hosts, B lymphocytes expand poorly, but fully reconstitute the pool of natural IgM-secreting cells and circulating IgM levels. By using sequential cell transfers and B cell populations from several mutant mice, we were able to identify novel mechanisms regulating the size of the IgM-secreting B cell pool. Contrary to previous mechanisms described regulating homeostasis, which involve competition for the same niche by cells having overlapping survival requirements, homeostasis of the innate IgM-secreting B cell pool is also achieved when B cell populations are able to monitor the number of activated B cells by detecting their secreted products. Notably, B cell populations are able to assess the density of activated B cells by sensing their secreted IgG. This process involves the FcγRIIB, a low-affinity IgG receptor that is expressed on B cells and acts as a negative regulator of B cell activation, and its intracellular effector the inositol phosphatase SHIP. As a result of the engagement of this inhibitory pathway, the number of activated IgM-secreting B cells is kept under control. We hypothesize that malfunction of this quorum-sensing mechanism may lead to uncontrolled B cell activation and autoimmunity.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00771602
Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Wednesday, January 9, 2013 - 9:02:08 AM
Last modification on : Tuesday, October 19, 2021 - 10:27:27 PM
Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Wednesday, January 9, 2013 - 9:02:08 AM
Last modification on : Tuesday, October 19, 2021 - 10:27:27 PM
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