Quorum Sensing Contributes to Activated IgM-Secreting B Cell Homeostasis. - Archive ouverte HAL Access content directly
Journal Articles Journal of Immunology Year : 2013

Quorum Sensing Contributes to Activated IgM-Secreting B Cell Homeostasis.

(1) , (1) , (1) , (1) , (1) , (1) , (2) , (3) , (1) , (4) , (4, 5) , (1)
1
2
3
4
5

Abstract

Maintenance of plasma IgM levels is critical for immune system function and homeostasis in humans and mice. However, the mechanisms that control homeostasis of the activated IgM-secreting B cells are unknown. After adoptive transfer into immune-deficient hosts, B lymphocytes expand poorly, but fully reconstitute the pool of natural IgM-secreting cells and circulating IgM levels. By using sequential cell transfers and B cell populations from several mutant mice, we were able to identify novel mechanisms regulating the size of the IgM-secreting B cell pool. Contrary to previous mechanisms described regulating homeostasis, which involve competition for the same niche by cells having overlapping survival requirements, homeostasis of the innate IgM-secreting B cell pool is also achieved when B cell populations are able to monitor the number of activated B cells by detecting their secreted products. Notably, B cell populations are able to assess the density of activated B cells by sensing their secreted IgG. This process involves the FcγRIIB, a low-affinity IgG receptor that is expressed on B cells and acts as a negative regulator of B cell activation, and its intracellular effector the inositol phosphatase SHIP. As a result of the engagement of this inhibitory pathway, the number of activated IgM-secreting B cells is kept under control. We hypothesize that malfunction of this quorum-sensing mechanism may lead to uncontrolled B cell activation and autoimmunity.

Dates and versions

pasteur-00771602 , version 1 (09-01-2013)

Identifiers

Cite

Caroline Montaudouin, Marie Anson, Yi Hao, Susanne V Duncker, Tahia Fernandez, et al.. Quorum Sensing Contributes to Activated IgM-Secreting B Cell Homeostasis.. Journal of Immunology, 2013, 190 (1), pp.106-14. ⟨10.4049/jimmunol.1200907⟩. ⟨pasteur-00771602⟩
125 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More