Skip to Main content Skip to Navigation
Journal articles

Chikungunya Virus and the Mosquito Vector Aedes aegypti in New Caledonia (South Pacific Region).

Abstract : Abstract Chikungunya virus (CHIKV) is transmitted to humans through the bite of Aedes mosquitoes. During the 2005-2006 epidemic that occurred in the Indian Ocean Islands, a viral strain harboring a substitution of an alanine to valine at position 226 (E1-A226V) of the E1 glycoprotein enhanced the transmissibility of CHIKV by Aedes albopictus. In March 2011, autochthonous transmission of CHIKV was reported in New Caledonia (NC), an island located in the southwest Pacific Ocean. This was the first report of local chikungunya (CHIK) transmission in this region of the world. Phylogenetic analysis based on the complete genome demonstrated that the CHIKV-NC strain isolated from the first autochthonous human case belongs to the Asian lineage. This is consistent with the Indonesian origin of CHIK cases previously imported and detected. Thus the CHIKV-NC does not present a valine substitution at position E1-226. In New Caledonia, the putative vector of CHIKV is Aedes aegypti, since no other potential vector has ever been described. For example, A. albopictus is not found in NC. Vector competence experiments showed that A. aegypti from New Caledonia was able to transmit, as early as 3 days post-infection, two CHIKV strains: CHIKV-NC belonging to the Asian lineage, and CHIKV-RE from Reunion Island harboring the E1-A226V mutation. Thus the extrinsic incubation period of both CHIKV strains in this vector species could be considered to be quite short. These results illustrate the threat of the spread of CHIKV in the South Pacific region. From February to June 2011 (the end of the alert), only 33 cases were detected. Implementation of drastic vector control measures and the occurrence of the cold season probably helped to limit the extent of the outbreak, but other factors may have also been involved and are discussed.
Complete list of metadatas

Cited literature [27 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-00764397
Contributor : Myrielle Dupont-Rouzeyrol <>
Submitted on : Friday, December 13, 2013 - 7:00:03 AM
Last modification on : Wednesday, May 20, 2020 - 4:40:05 PM
Long-term archiving on: : Friday, March 14, 2014 - 9:22:00 AM

File

Chikungunya_Virus_and_the_Mosq...
Publisher files allowed on an open archive

Identifiers

Citation

Myrielle Dupont-Rouzeyrol, Valérie Caro, Laurent Guillaumot, Marie Vazeille, Eric d'Ortenzio, et al.. Chikungunya Virus and the Mosquito Vector Aedes aegypti in New Caledonia (South Pacific Region).. Vector-Borne and Zoonotic Diseases, Mary Ann Liebert, 2012, epub ahead of print. ⟨10.1089/vbz.2011.0937⟩. ⟨pasteur-00764397⟩

Share

Metrics

Record views

812

Files downloads

774