S. Adams, D. W. O-'neill, D. Nonaka, E. Hardin, L. Chiriboga et al., Immunization of Malignant Melanoma Patients with Full-Length NY-ESO-1 Protein Using TLR7 Agonist Imiquimod as Vaccine Adjuvant, The Journal of Immunology, vol.181, issue.1, pp.776-784, 2008.
DOI : 10.4049/jimmunol.181.1.776

M. L. Albert, Opinion: Death-defying immunity: do apoptotic cells influence antigen processing and presentation?, Nature Reviews Immunology, vol.104, issue.3, pp.223-231, 2004.
DOI : 10.1038/nri11308
URL : https://hal.archives-ouvertes.fr/pasteur-01402360

M. L. Albert, M. Jegathesan, D. , and R. B. , Dendritic cell maturation is required for the crosstolerization of CD8+ T cells, Nature Immunology, vol.326, issue.11, pp.1010-1017, 2001.
DOI : 10.1038/ni722

M. L. Albert, B. Sauter, and N. Bhardwaj, Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs, Nature, vol.392, issue.6671, pp.86-89, 1998.
DOI : 10.1038/32183

J. R. Almeida, D. A. Price, L. Papagno, Z. A. Arkoub, D. Sauce et al., T cells is reflected by their avidity, polyfunctionality, and clonal turnover, The Journal of Experimental Medicine, vol.93, issue.10, pp.2473-2485, 2007.
DOI : 10.1016/S0022-1759(02)00195-3
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118466

J. D. Altman, P. A. Moss, P. J. Goulder, D. H. Barouch, M. G. Mcheyzer-williams et al., Phenotypic Analysis of Antigen-Specific T Lymphocytes, Science, vol.274, issue.5284, pp.94-96, 1996.
DOI : 10.1126/science.274.5284.94

S. Amigorena, Cancer immunotherapy using dendritic cell-derived exosomes, Medicina (B Aires), vol.60, pp.51-54, 2000.

V. P. Badovinac, J. S. Haring, and J. T. Harty, Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection, Immunity, vol.26, issue.6, pp.827-841, 2007.
DOI : 10.1016/j.immuni.2007.04.013

S. R. Bennett, F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. Miller et al., Help for cytotoxic-T-cell responses is mediated by CD40 signalling, Nature, vol.393, pp.478-480, 1998.

S. R. Bennett, F. R. Carbone, F. Karamalis, J. F. Miller, and W. R. Heath, T Cell Help, The Journal of Experimental Medicine, vol.152, issue.1, pp.65-70, 1997.
DOI : 10.1084/jem.169.3.603

P. Bousso, A. Casrouge, J. D. Altman, M. Haury, J. Kanellopoulos et al., Individual Variations in the Murine T Cell Response to a Specific Peptide Reflect Variability in Naive Repertoires, Immunity, vol.9, issue.2, pp.169-178, 1998.
DOI : 10.1016/S1074-7613(00)80599-3

M. R. Buckwalter and P. K. Srivastava, ???It is the antigen(s), stupid??? and other lessons from over a decade of vaccitherapy of human cancer, Seminars in Immunology, vol.20, issue.5, pp.296-300, 2008.
DOI : 10.1016/j.smim.2008.07.003

J. P. Carralot, J. Probst, I. Hoerr, B. Scheel, R. Teufel et al., Polarization of immunity induced by direct injection of naked sequencestabilized mRNA vaccines, Cell. Mol. Life Sci, vol.61, pp.2418-2424, 2004.

D. M. Catron, L. K. Rusch, J. Hataye, A. A. Itano, and M. K. Jenkins, T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central???memory cells, The Journal of Experimental Medicine, vol.159, issue.4, pp.1045-1054, 2006.
DOI : 10.1084/jem.176.1.47

S. Celli, Z. Garcia, and P. Bousso, CD4 T cells integrate signals delivered during successive DC encounters in vivo, The Journal of Experimental Medicine, vol.202, issue.9, pp.1271-1278, 2005.
DOI : 10.1038/76917

P. A. Darrah, D. T. Patel, P. M. De-luca, R. W. Lindsay, D. F. Davey et al., Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major, Nature Medicine, vol.313, issue.7, pp.843-850, 2007.
DOI : 10.1038/nm1592

J. M. Den-haan, S. M. Lehar, and M. J. Bevan, Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo, The Journal of Experimental Medicine, vol.56, issue.12, pp.1685-1696, 2000.
DOI : 10.1084/jem.192.2.205

M. Diken, S. Kreiter, A. Selmi, C. M. Britten, C. Huber et al., Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation, Gene Therapy, vol.180, issue.7, 2011.
DOI : 10.1038/gt.2010.52

S. R. Dillon, S. C. Jameson, and P. J. Fink, V beta 5+ T cell receptors skew toward OVA+ H-2Kb recognition, J. Immunol, vol.152, pp.1790-1801, 1994.

B. T. Edelson, W. Kc, R. Juang, M. Kohyama, L. A. Benoit et al., conventional dendritic cells, The Journal of Experimental Medicine, vol.144, issue.4, pp.823-836, 2010.
DOI : 10.1016/S1074-7613(00)80649-4

B. J. Flynn, K. Kastenmuller, U. Wille-reece, G. D. Tomaras, M. Alam et al., Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates, Proc. Natl. Acad. Sci. U.S.A, pp.7131-7136, 2011.
DOI : 10.1073/pnas.1103869108

R. Fontana, M. Bregni, A. Cipponi, L. Raccosta, C. Rainelli et al., Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients, Blood, vol.113, issue.8, pp.1651-1660, 2009.
DOI : 10.1182/blood-2008-07-168666

M. T. Heemels and H. Ploegh, Generation, Translocation, and Presentation of MHC Class I-Restricted Peptides, Annual Review of Biochemistry, vol.64, issue.1, pp.463-491, 1995.
DOI : 10.1146/annurev.bi.64.070195.002335

H. Jusforgues-saklani, M. Uhl, N. Blachere, F. Lemaitre, O. Lantz et al., Antigen Persistence Is Required for Dendritic Cell Licensing and CD8+ T Cell Cross-Priming, The Journal of Immunology, vol.181, issue.5, pp.3067-3076, 2008.
DOI : 10.4049/jimmunol.181.5.3067
URL : https://hal.archives-ouvertes.fr/pasteur-01402307

E. R. Kearney, K. A. Pape, D. Y. Loh, and M. K. Jenkins, Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo, Immunity, vol.1, issue.4, pp.327-339, 1994.
DOI : 10.1016/1074-7613(94)90084-1

C. Kurts, W. R. Heath, F. R. Carbone, J. Allison, J. F. Miller et al., Constitutive class I-restricted exogenous presentation of self antigens in vivo, Journal of Experimental Medicine, vol.184, issue.3, pp.923-930, 1996.
DOI : 10.1084/jem.184.3.923

A. Lanzavecchia, Immunology. Licence to kill, Nature, vol.393, issue.6684, pp.413-414, 1998.
DOI : 10.1038/30845

M. P. Longhi, C. Trumpfheller, J. Idoyaga, M. Caskey, I. Matos et al., Th1 immunity with poly IC as adjuvant, The Journal of Experimental Medicine, vol.161, issue.7, pp.1589-1602, 2009.
DOI : 10.4049/jimmunol.181.10.6923

A. L. Marzo, K. D. Klonowski, L. Bon, A. Borrow, P. Tough et al., Initial T cell frequency dictates memory CD8+ T cell lineage commitment, Nature Immunology, vol.166, issue.8, pp.793-799, 2005.
DOI : 10.1126/science.279.5354.1223

I. Mellman and R. M. Steinman, Dendritic Cells, Cell, vol.106, issue.3, pp.255-258, 2001.
DOI : 10.1016/S0092-8674(01)00449-4

M. S. Mitchell, J. Abrams, J. A. Thompson, M. Kashani-sabet, R. C. Deconti et al., Randomized Trial of an Allogeneic Melanoma Lysate Vaccine With Low-Dose Interferon Alfa-2b Compared With High-Dose Interferon Alfa-2b for Resected Stage III Cutaneous Melanoma, Journal of Clinical Oncology, vol.25, issue.15, pp.2078-2085, 2007.
DOI : 10.1200/JCO.2006.10.1709

J. J. Moon, H. H. Chu, M. Pepper, S. J. Mcsorley, S. C. Jameson et al., Naive CD4+ T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response Magnitude, Immunity, vol.27, issue.2, pp.203-213, 2007.
DOI : 10.1016/j.immuni.2007.07.007

C. F. Nicodemus and J. S. Berek, TLR3 agonists as immunotherapeutic agents, Immunotherapy, vol.2, issue.2, pp.137-140, 2010.
DOI : 10.2217/imt.10.8

J. J. Obar, K. M. Khanna, and L. Lefrancois, Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection, Immunity, vol.28, issue.6, pp.859-869, 2008.
DOI : 10.1016/j.immuni.2008.04.010

H. Okada, P. Kalinski, R. Ueda, A. Hoji, G. Kohanbash et al., T-Cell Responses Against Novel Glioma???Associated Antigen Peptides and Clinical Activity by Vaccinations With ??-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma, Journal of Clinical Oncology, vol.29, issue.3, pp.330-336, 2011.
DOI : 10.1200/JCO.2010.30.7744

A. K. Palucka, H. Ueno, J. Connolly, F. Kerneis-norvell, J. P. Blanck et al., Dendritic Cells Loaded With Killed Allogeneic Melanoma Cells can Induce Objective Clinical Responses and MART-1 Specific CD8+ T-cell Immunity, Journal of Immunotherapy, vol.29, issue.5, pp.545-557, 2006.
DOI : 10.1097/01.cji.0000211309.90621.8b

C. Pannetier, M. Cochet, S. Darche, A. Casrouge, M. Zoller et al., The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments., Proceedings of the National Academy of Sciences, vol.90, issue.9, pp.4319-4323, 1993.
DOI : 10.1073/pnas.90.9.4319

M. L. Precopio, M. R. Betts, J. Parrino, D. A. Price, E. Gostick et al., T cell responses, The Journal of Experimental Medicine, vol.70, issue.6, pp.1405-1416, 2007.
DOI : 10.1016/S0145-305X(02)00039-3

M. Prlic, G. Hernandez-hoyos, and M. J. Bevan, T cell response, The Journal of Experimental Medicine, vol.195, issue.9, pp.2135-2143, 2006.
DOI : 10.4049/jimmunol.166.5.3402

M. Rehli, Of mice and men: species variations of Toll-like receptor expression, Trends in Immunology, vol.23, issue.8, pp.375-378, 2002.
DOI : 10.1016/S1471-4906(02)02259-7

J. P. Ridge, D. Rosa, F. Matzinger, and P. , A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell, Nature, vol.393, issue.6684, pp.474-478, 1998.
DOI : 10.1038/30989

V. Russo, A. Cipponi, L. Raccosta, C. Rainelli, R. Fontana et al., Lymphocytes genetically modified to express tumor antigens target DCs in vivo and induce antitumor immunity, Journal of Clinical Investigation, vol.117, issue.10, pp.3087-3096, 2007.
DOI : 10.1172/JCI30605DS1

S. P. Schoenberger, R. E. Toes, E. I. Van-der-voort, R. Offringa, and C. J. Melief, T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions, Nature, vol.393, issue.6684, pp.480-483, 1998.
DOI : 10.1038/31002

R. A. Seder, P. A. Darrah, and M. Roederer, T-cell quality in memory and protection: implications for vaccine design, Nature Reviews Immunology, vol.27, issue.4, pp.247-258, 2008.
DOI : 10.1038/nri2274

J. W. Van-heijst, C. Gerlach, E. Swart, D. Sie, C. Nunes-alves et al., Recruitment of Antigen-Specific CD8+ T Cells in Response to Infection Is Markedly Efficient, Science, vol.325, issue.5945, pp.1265-1269, 2009.
DOI : 10.1126/science.1175455

B. Weide, J. P. Carralot, A. Reese, B. Scheel, T. K. Eigentler et al., Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA, Journal of Immunotherapy, vol.31, issue.2, pp.180-188, 2008.
DOI : 10.1097/CJI.0b013e31815ce501

N. S. Wilson, G. M. Behrens, R. J. Lundie, C. M. Smith, J. Waithman et al., Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity, Nature Immunology, vol.137, issue.2, pp.165-172, 2006.
DOI : 10.1038/ni1300

J. Wolfers, A. Lozier, G. Raposo, A. Regnault, C. Thery et al., Tumorderived exosomes are a source of shared tumor rejection antigens for CTL cross-priming, Nature Medicine, vol.7, issue.3, pp.297-303, 2001.
DOI : 10.1038/85438

D. Zehn, S. Y. Lee, and M. J. Bevan, Complete but curtailed T-cell response to very low-affinity antigen, Nature, vol.194, issue.7235, pp.211-214, 2009.
DOI : 10.1038/nature07657