Abstract : We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of SuzukieMiyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00755935
Contributor : Yves Janin <>
Submitted on : Thursday, November 22, 2012 - 11:02:44 AM Last modification on : Wednesday, November 11, 2020 - 9:52:02 AM