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Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

Mikhail Ermolenko 1 Sandrine Guillou 2 Yves Janin 2
1 ICSN - Institut de Chimie des Substances Naturelles
2 UCO - Chimie organique
Abstract : We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of SuzukieMiyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.
Keywords : Building blocks 3/5-Trifluoromethylpyrazoles Pyrazole-3/5-carboxylic acids Cross-coupling Palladium catalysis
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00755935
Contributor : Yves Janin <>
Submitted on : Thursday, November 22, 2012 - 11:02:44 AM
Last modification on : Wednesday, November 11, 2020 - 9:52:02 AM

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Mikhail Ermolenko, Sandrine Guillou, Yves Janin. Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles. Tetrahedron, Elsevier, 2013, 69 (1), pp.257-263. ⟨10.1016/j.tet.2012.10.034⟩. ⟨pasteur-00755935⟩

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