Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses.

Sai-Wen Tang (1) , Aurelie Ducroux (2) , Kuan-Teh Jeang (1) , Christine Neuveut (2)

1 Molecular Virology Section, Laboratory of Molecular Microbiology
2 Hépacivirus et immunité innée

ABSTRACT: Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert the cell's autophagic process. Here, we review the interactions between viruses and cells in regards to cellular autophagy. Using findings from hepatitis B virus and human retroviruses, HIV-1 and HTLV-1, we discuss mechanisms used by viruses to usurp cellular autophagy in ways that benefit viral replication.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Virology

Sai-Wen Tang, Aurelie Ducroux, Kuan-Teh Jeang, Christine Neuveut. Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses.. Journal of Biomedical Science, 2012, 19 (1), pp.92. ⟨10.1186/1423-0127-19-92⟩. ⟨pasteur-00750566⟩