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CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity.

Abstract : CCR5 is the major HIV-1 entry coreceptor. RANTES/CCL5 analogs are more potent inhibitors of infection than native chemokines; one class activates and internalizes CCR5, one neither activates nor internalizes, and a third partially internalizes without activation. Here we show that mutations in CCR5 transmembrane domains differentially impact the activity of these three inhibitor classes, suggesting that the transmembrane region of CCR5, a key interaction site for inhibitors, is a sensitive molecular switch, modulating receptor activity.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00731737
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Submitted on : Thursday, September 13, 2012 - 12:08:35 PM
Last modification on : Thursday, April 7, 2022 - 10:10:30 AM
Long-term archiving on: : Friday, December 16, 2016 - 12:41:40 PM

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Won-Tak Choi, Rebecca Nedellec, Mia Coetzer, Philippe Colin, Bernard Lagane, et al.. CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity.. Journal of Virology, American Society for Microbiology, 2012, 86 (18), pp.10218-20. ⟨10.1128/JVI.00353-12⟩. ⟨pasteur-00731737⟩

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