CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity. - Archive ouverte HAL Access content directly
Journal Articles Journal of Virology Year : 2012

CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity.

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Abstract

CCR5 is the major HIV-1 entry coreceptor. RANTES/CCL5 analogs are more potent inhibitors of infection than native chemokines; one class activates and internalizes CCR5, one neither activates nor internalizes, and a third partially internalizes without activation. Here we show that mutations in CCR5 transmembrane domains differentially impact the activity of these three inhibitor classes, suggesting that the transmembrane region of CCR5, a key interaction site for inhibitors, is a sensitive molecular switch, modulating receptor activity.
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Dates and versions

pasteur-00731737 , version 1 (13-09-2012)

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Won-Tak Choi, Rebecca Nedellec, Mia Coetzer, Philippe Colin, Bernard Lagane, et al.. CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity.. Journal of Virology, 2012, 86 (18), pp.10218-20. ⟨10.1128/JVI.00353-12⟩. ⟨pasteur-00731737⟩
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