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Cytoskeletal cross-talk in the control of T cell antigen receptor signaling.

Abstract : T cell antigen receptor signaling is triggered and controlled in specialized cellular interfaces formed between T cells and antigen-presenting cells named immunological synapses. Both microtubules and actin cytoskeleton rearrange at the immunological synapse in response to T cell receptor triggering, ensuring in turn the accuracy of intracellular signaling. Recent reports show that the cross-talk between the cortical actin cytoskeleton and microtubule networks is key for structuring the immunological synapse and for controlling T cell receptor signaling. Immunological synapse architecture and the interaction between the signaling machinery and various cytoskeletal elements are therefore crucial for the fine-tuning of T cell signaling.
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Submitted on : Tuesday, July 17, 2012 - 5:20:58 PM
Last modification on : Monday, January 13, 2020 - 5:08:07 PM

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Rémi Lasserre, Andres Alcover. Cytoskeletal cross-talk in the control of T cell antigen receptor signaling.. FEBS Letters, Wiley, 2010, 584 (24), pp.4845-50. ⟨10.1016/j.febslet.2010.09.001⟩. ⟨pasteur-00718645⟩

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