Skip to Main content Skip to Navigation
Journal articles

PP2A targeting by viral proteins: a widespread biological strategy from DNA/RNA tumor viruses to HIV-1.

Abstract : Protein phosphatase 2A (PP2A) is a large family of holoenzymes that comprises 1% of total cellular proteins and accounts for the majority of Ser/Thr phosphatase activity in eukaryotic cells. Although initially viewed as constitutive housekeeping enzymes, it is now well established that PP2A proteins represent a family of highly and sophistically regulated phosphatases. The past decade, multiple complementary studies have improved our knowledge about structural and functional regulation of PP2A holoenzymes. In this regard, after summarizing major cellular regulation, this review will mainly focus on discussing a particulate biological strategy, used by various viruses, which is based on the targeting of PP2A enzymes by viral proteins in order to specifically deregulate, for their own benefit, cellular pathways of their hosts. The impact of such PP2A targeting for research in human diseases, and in further therapeutic developments, is also discussed.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-00649918
Contributor : Marie-Christine Vougny <>
Submitted on : Friday, December 9, 2011 - 10:11:33 AM
Last modification on : Friday, May 29, 2020 - 4:48:33 PM

Links full text

Identifiers

Collections

Citation

Julien Guergnon, Angélique N Godet, Amandine Galioot, Pierre Barthélémy Falanga, Jean-Hervé Colle, et al.. PP2A targeting by viral proteins: a widespread biological strategy from DNA/RNA tumor viruses to HIV-1.. BBA - Biochimica et Biophysica Acta, Elsevier, 2011, 1812 (11), pp.1498-507. ⟨10.1016/j.bbadis.2011.07.001⟩. ⟨pasteur-00649918⟩

Share

Metrics

Record views

385