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Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks

Sandrine Guillou 1 Frédéric Bonhomme 1 Mikhail Ermolenko 2 Yves L. Janin 1
1 Chimie Organique
2 ICSN - Institut de Chimie des Substances Naturelles
Abstract : The pyrazole nucleus has recently become a recurrent scaffold in the research fields of CropScience and oncology. We report here the preparation of an array of 4- and 5-iodinated pyrazole derivatives, such as 4-iodo-3-trifluoromethylpyrazole or ethyl 5-iodo-4-carboxy-3-trifluoromethylpyrazoles. This work provide access to many new pyrazole derivative, including 11 original out of 16 iodinated building blocks, thus opening accesses to new chemical entities featuring a pyrazole nucleus.
keyword : Building blocks 5-Iodopyrazoles 4-Iodopyrazoles 4 5-Diiodopyrazoles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00629132
Contributor : Yves Janin <>
Submitted on : Wednesday, October 5, 2011 - 10:32:39 AM
Last modification on : Saturday, July 3, 2021 - 3:44:16 AM

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PASTEUR | CNRS | ICSN | INC-CNRS | GS-HEALTH-DRUG-SCIENCES

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Sandrine Guillou, Frédéric Bonhomme, Mikhail Ermolenko, Yves L. Janin. Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks. Tetrahedron, Elsevier, 2011, 67 (44), pp.8451-8457. ⟨10.1016/j.tet.2011.09.029⟩. ⟨pasteur-00629132⟩

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