Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks

Sandrine Guillou (1) , Frédéric J. Bonhomme (1) , Mikhail S. Ermolenko (2) , Yves L. Janin (1)

1 Chimie Organique
2 ICSN - Institut de Chimie des Substances Naturelles

The pyrazole nucleus has recently become a recurrent scaffold in the research fields of CropScience and oncology. We report here the preparation of an array of 4- and 5-iodinated pyrazole derivatives, such as 4-iodo-3-trifluoromethylpyrazole or ethyl 5-iodo-4-carboxy-3-trifluoromethylpyrazoles. This work provide access to many new pyrazole derivative, including 11 original out of 16 iodinated building blocks, thus opening accesses to new chemical entities featuring a pyrazole nucleus.

Keywords: Building blocks 5-Iodopyrazoles 4-Iodopyrazoles 4; 5-Diiodopyrazoles

Domains: Chemical Sciences; Organic chemistry

Sandrine Guillou, Frédéric J. Bonhomme, Mikhail S. Ermolenko, Yves L. Janin. Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks. Tetrahedron, 2011, 67 (44), pp.8451-8457. ⟨10.1016/j.tet.2011.09.029⟩. ⟨pasteur-00629132⟩