Skip to Main content Skip to Navigation
Journal articles

Decidual soluble factors participate in the control of HIV-1 infection at the maternofetal interface

Abstract : Background
Maternofetal transmission (MFT) of HIV-1 is relatively rare during the first trimester of pregnancy despite the permissivity of placental cells for cell-to-cell HIV-1 infection. Invasive placental cells interact directly with decidual cells of the uterine mucosa during the first months of pregnancy, but the role of the decidua in the control of HIV-1 transmission is unknown.
Results
We found that decidual mononuclear cells naturally produce low levels of IL-10, IL-12, IL-15, TNF-α, IFN-α, IFN-γ and CXCL-12 (SDF-1), and large amounts of CCL-2 (MCP1), CCL-3 (MIP-1α), CCL-4 (MIP-1β), CCL-5 (Rantes), CXCL-10 (IP-10), IL-6 and IL-8. CCL-3 and CCL-4 levels were significantly upregulated by in vitro infection with R5 HIV-1 but not X4. Decidual CD14+ antigen presenting cells were the main CCL-3 and CCL-4 producers among decidual leukocytes. R5 and X4 HIV-1 infection was inhibited by decidual cell culture supernatants in vitro. Using HIV-1 pseudotypes, we found that inhibition of the HIV-1 entry step was inhibited by decidual soluble factors.
Conclusion
Our findings show that decidual innate immunity (soluble factors) is involved in the control of HIV-1 infection at the maternofetal interface. The decidua could thus serve as a mucosal model for identifying correlates of protection against HIV-1 infection.
Document type :
Journal articles
Complete list of metadatas

Cited literature [56 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-00629082
Contributor : Ed. Bmc <>
Submitted on : Wednesday, October 5, 2011 - 7:04:25 AM
Last modification on : Tuesday, October 13, 2020 - 3:46:08 PM
Long-term archiving on: : Tuesday, November 13, 2012 - 3:11:06 PM

Files

1742-4690-8-58.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Romain Marlin, Marie-Thérèse Nugeyre, Marion Duriez, Claude Cannou, Anne Le Breton, et al.. Decidual soluble factors participate in the control of HIV-1 infection at the maternofetal interface. Retrovirology, BioMed Central, 2011, 8 (1), pp.58. ⟨10.1186/1742-4690-8-58⟩. ⟨pasteur-00629082⟩

Share

Metrics

Record views

484

Files downloads

1149