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Notch signaling is necessary for adult, but not fetal, development of RORγt(+) innate lymphoid cells.

Abstract : The transcription factor RORγt is required for the development of several innate lymphoid populations, such as lymphoid tissue-inducer cells (LTi cells) and cells that secrete interleukin 17 (IL-17) or IL-22. The progenitor cells as well as the developmental stages that lead to the emergence of RORγt(+) innate lymphoid cells (ILCs) remain undefined. Here we identify the chemokine receptor CXCR6 as an additional marker of the development of ILCs and show that common lymphoid progenitors lost B cell and T cell potential as they successively acquired expression of the integrin α(4)β(7) and CXCR6. Whereas fetal RORγt(+) cells matured in the fetal liver environment, adult bone marrow-derived RORγt(+) ILCs matured outside the bone marrow, in a Notch2-dependent manner. Therefore, fetal and adult environments influence the differentiation of RORγt(+) cells differently.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00627238
Contributor : Marie-Christine Vougny <>
Submitted on : Wednesday, September 28, 2011 - 10:54:36 AM
Last modification on : Friday, March 27, 2020 - 3:51:23 AM

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Cécilie Possot, Sandrine Schmutz, Sylvestre Chea, Laurent Boucontet, Anne Louise, et al.. Notch signaling is necessary for adult, but not fetal, development of RORγt(+) innate lymphoid cells.. Nature Immunology, Nature Publishing Group, 2011, 12 (10), pp.949-58. ⟨10.1038/ni.2105⟩. ⟨pasteur-00627238⟩

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