J. Pfeiffer and K. Kirkegaard, A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity, Proceedings of the National Academy of Sciences, vol.100, issue.12, pp.7289-7294, 2003.
DOI : 10.1073/pnas.1232294100

J. Pfeiffer and K. Kirkegaard, Increased Fidelity Reduces Poliovirus Fitness and Virulence under Selective Pressure in Mice, PLoS Pathogens, vol.78, issue.2, p.11, 2005.
DOI : 0027-8424(1981)078[4887:MCOPCA]2.0.CO;2

M. Vignuzzi, J. Stone, J. Arnold, C. Cameron, and R. Andino, Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population, Nature, vol.77, issue.7074, pp.344-348, 2006.
DOI : 10.1038/nature04388

M. Vignuzzi, E. Wendt, and R. Andino, Engineering attenuated virus vaccines by controlling replication fidelity, Nature Medicine, vol.7, issue.2, pp.154-161, 2008.
DOI : 10.1038/nm1726

S. Crotty, C. Cameron, and R. Andino, RNA virus error catastrophe: Direct molecular test by using ribavirin, Proceedings of the National Academy of Sciences, vol.98, issue.12, pp.6895-6900, 2001.
DOI : 10.1073/pnas.111085598

W. Parker, Metabolism and antiviral activity of ribavirin, Virus Research, vol.107, issue.2, pp.165-171, 2005.
DOI : 10.1016/j.virusres.2004.11.006

S. Crotty, The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen, Nat Med, vol.6, pp.1375-1379, 2000.

A. Contreras, Viral RNA Mutations Are Region Specific and Increased by Ribavirin in a Full-Length Hepatitis C Virus Replication System, Journal of Virology, vol.76, issue.17, pp.8505-8517, 2002.
DOI : 10.1128/JVI.76.17.8505-8517.2002

F. Gillin and N. Nossal, Control of mutation frequency by bacteriophage T4 DNA polymerase. I. The CB120 antimutator DNA polymerase is defective in strand displacement, J Biol Chem, vol.251, pp.5219-5224, 1976.

R. Schaaper, Antimutator mutants in bacteriophage T4 and Escherichia coli, Genetics, vol.148, pp.1579-1585, 1998.

R. Chen, M. Quinones-mateu, and L. Mansky, Drug Resistance, Virus Fitness and HIV-1 Mutagenesis, Current Pharmaceutical Design, vol.10, issue.32, pp.4065-4070, 2004.
DOI : 10.2174/1381612043382404

L. Mansky, D. Pearl, and L. Gajary, Combination of Drugs and Drug-Resistant Reverse Transcriptase Results in a Multiplicative Increase of Human Immunodeficiency Virus Type 1 Mutant Frequencies, Journal of Virology, vol.76, issue.18, pp.9253-9259, 2002.
DOI : 10.1128/JVI.76.18.9253-9259.2002

M. Wainberg, Enhanced Fidelity of 3TC-Selected Mutant HIV-1 Reverse Transcriptase, Science, vol.271, issue.5253, pp.1282-1285, 1996.
DOI : 10.1126/science.271.5253.1282

A. Ciota, Characterization of mosquito-adapted West Nile virus, Journal of General Virology, vol.89, issue.7, pp.1633-1642, 2008.
DOI : 10.1099/vir.0.2008/000893-0

L. Coffey, Arbovirus evolution in vivo is constrained by host alternation, Proceedings of the National Academy of Sciences, vol.105, issue.19, pp.6970-6975, 2008.
DOI : 10.1073/pnas.0712130105

L. Coffey and M. Vignuzzi, Host Alternation of Chikungunya Virus Increases Fitness while Restricting Population Diversity and Adaptability to Novel Selective Pressures, Journal of Virology, vol.85, issue.2, pp.1025-1035, 2011.
DOI : 10.1128/JVI.01918-10
URL : https://hal.archives-ouvertes.fr/pasteur-00546712

I. Greene, Effect of Alternating Passage on Adaptation of Sindbis Virus to Vertebrate and Invertebrate Cells, Journal of Virology, vol.79, issue.22, pp.14253-14260, 2005.
DOI : 10.1128/JVI.79.22.14253-14260.2005

G. Jerzak, I. Brown, P. Shi, L. Kramer, and G. Ebel, Genetic diversity and purifying selection in West Nile virus populations are maintained during host switching, Virology, vol.374, issue.2, pp.256-260, 2008.
DOI : 10.1016/j.virol.2008.02.032

I. Novella, C. Hershey, C. Escarmis, E. Domingo, and J. Holland, Lack of evolutionary stasis during alternating replication of an arbovirus in insect and mammalian cells, Journal of Molecular Biology, vol.287, issue.3, pp.459-465, 1999.
DOI : 10.1006/jmbi.1999.2635

P. Turner, N. Morales, B. Alto, and S. Remold, ROLE OF EVOLVED HOST BREADTH IN THE INITIAL EMERGENCE OF AN RNA VIRUS, Evolution, vol.38, issue.11, pp.3273-3286, 2010.
DOI : 10.1111/j.1558-5646.2010.01051.x

N. Vasilakis, Mosquitoes Put the Brake on Arbovirus Evolution: Experimental Evolution Reveals Slower Mutation Accumulation in Mosquito Than Vertebrate Cells, PLoS Pathogens, vol.79, issue.1, p.1000467, 2009.
DOI : 10.1371/journal.ppat.1000467.t011

S. Weaver, A. Brault, W. Kang, and J. Holland, Genetic and fitness changes accompanying adaptation of an arbovirus to vertebrate and invertebrate cells, J Virol, vol.73, pp.4316-4326, 1999.

A. Powers and C. Logue, Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus, Journal of General Virology, vol.88, issue.9, pp.2363-2377, 2007.
DOI : 10.1099/vir.0.82858-0

M. Grandadam, Chikungunya Virus, Southeastern France, Emerging Infectious Diseases, vol.17, issue.5, pp.910-913, 2011.
DOI : 10.3201/eid1705.101873

S. Beaucourt, Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency, Journal of Visualized Experiments, vol.10, issue.52, 2011.
DOI : 10.3791/2953
URL : https://hal.archives-ouvertes.fr/pasteur-00601728

L. Levi, Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds, PLoS Pathogens, vol.104, issue.Pt 1, p.1001163, 2010.
DOI : 10.1371/journal.ppat.1001163.s004
URL : https://hal.archives-ouvertes.fr/pasteur-00530598

M. Sierra, Foot-and-Mouth Disease Virus Mutant with Decreased Sensitivity to Ribavirin: Implications for Error Catastrophe, Journal of Virology, vol.81, issue.4, pp.2012-2024, 2007.
DOI : 10.1128/JVI.01606-06

T. Couderc, A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease, PLoS Pathogens, vol.41, issue.2, p.29, 2008.
DOI : 10.1371/journal.ppat.0040029.sg003
URL : https://hal.archives-ouvertes.fr/pasteur-01402310

L. Marcotte, Crystal Structure of Poliovirus 3CD Protein: Virally Encoded Protease and Precursor to the RNA-Dependent RNA Polymerase, Journal of Virology, vol.81, issue.7, pp.3583-3596, 2007.
DOI : 10.1128/JVI.02306-06

A. Thompson and O. Peersen, Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase, The EMBO Journal, vol.30, issue.17, pp.3462-3471, 2004.
DOI : 10.1016/0042-6822(88)90172-9

S. Elena and R. Sanjuán, Adaptive Value of High Mutation Rates of RNA Viruses: Separating Causes from Consequences, Journal of Virology, vol.79, issue.18, pp.11555-11558, 2005.
DOI : 10.1128/JVI.79.18.11555-11558.2005

R. Lanciotti, Chikungunya Virus in US Travelers Returning from India, 2006, Emerging Infectious Diseases, vol.13, issue.5, pp.764-767, 2006.
DOI : 10.3201/eid1305.070015

D. Weese, A. Emde, T. Rausch, A. Döring, and K. Reinert, RazerS--fast read mapping with sensitivity control, Genome Research, vol.19, issue.9, pp.1646-1654, 2009.
DOI : 10.1101/gr.088823.108

K. Tsetsarkin, D. Vanlandingham, C. Mcgee, and S. Higgs, A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential, PLoS Pathogens, vol.1, issue.12, p.201, 2007.
DOI : 10.1371/journal.ppat.0030201.st002

M. Vazeille, Two Chikungunya Isolates from the Outbreak of La Reunion (Indian Ocean) Exhibit Different Patterns of Infection in the Mosquito, Aedes albopictus, PLoS ONE, vol.103, issue.11, p.1168, 2007.
DOI : 10.1371/journal.pone.0001168.t003
URL : https://hal.archives-ouvertes.fr/hal-00196860