Presenilin 1 Controls ??-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons, The Journal of Cell Biology, vol.15, issue.2, pp.277-294, 1999. ,
DOI : 10.1074/jbc.274.13.8966
Inhibition of clathrin-coated pit assembly by an Eps15 mutant, J. Cell Sci, vol.112, pp.1303-1311, 1999. ,
Notch-induced Proteolysis and Nuclear Localization of the Delta Ligand, Journal of Biological Chemistry, vol.278, issue.16, pp.13607-13610, 2003. ,
DOI : 10.1074/jbc.C300016200
A Novel Proteolytic Cleavage Involved in Notch Signaling, Molecular Cell, vol.5, issue.2, pp.207-216, 2000. ,
DOI : 10.1016/S1097-2765(00)80417-7
Ubiquitination Precedes Internalization and Proteolytic Cleavage of Plasma Membrane-bound Glycine Receptors, Journal of Biological Chemistry, vol.276, issue.46, pp.42978-42985, 2001. ,
DOI : 10.1074/jbc.M102121200
Endocytic Pathway Abnormalities Precede Amyloid ?? Deposition in Sporadic Alzheimer???s Disease and Down Syndrome, The American Journal of Pathology, vol.157, issue.1, pp.277-286, 2000. ,
DOI : 10.1016/S0002-9440(10)64538-5
The discrepancy between presenilin subcellular localization and -secretase processing of amyloid precursor protein, J. Cell Biol, vol.154, pp.731-740, 2001. ,
Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins, Journal of Biological Chemistry, vol.272, issue.6, pp.3590-3598, 1997. ,
DOI : 10.1074/jbc.272.6.3590
A preseni- lin-1-dependent -secretase-like protease mediates release of Notch intracellular domain, Nature, vol.398, issue.6727, pp.518-522, 1999. ,
DOI : 10.1038/19083
Cytosolic interaction between Deltex and Notch ankyrin repeats implicates Deltex in the Notch signaling pathway, Development, vol.120, pp.473-481, 1994. ,
Simvastatin strongly reduces levels of Alzheimer's disease -amyloid peptides A42 and A40 in vitro and in vivo, Proc. Natl. Acad. Sci. USA, pp.5856-5861, 2001. ,
Signalling: ??-Secretase-mediated proteolysis in cell-surface-receptor signalling, Nature Reviews Molecular Cell Biology, vol.10, issue.9, pp.673-684, 2002. ,
DOI : 10.1038/nrm910
The suppressor of hairless protein participates in notch receptor signaling, Cell, vol.79, issue.2, pp.273-282, 1994. ,
DOI : 10.1016/0092-8674(94)90196-1
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex, Nature Cell Biology, vol.4, issue.3, pp.222-231, 2002. ,
DOI : 10.1038/ncb758
Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell???Cell Adhesion System and Is Recruited to Intercellular and Synaptic Contacts, Molecular Cell, vol.4, issue.6, pp.893-902, 1999. ,
DOI : 10.1016/S1097-2765(00)80219-1
Rab5-stimulated Up-regulation of the Endocytic Pathway Increases Intracellular ??-Cleaved Amyloid Precursor Protein Carboxyl-terminal Fragment Levels and A?? Production, Journal of Biological Chemistry, vol.278, issue.33, pp.31261-31268, 2003. ,
DOI : 10.1074/jbc.M304122200
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor, Journal of Biological Chemistry, vol.276, issue.37, pp.34371-34378, 2001. ,
DOI : 10.1074/jbc.M101343200
URL : https://hal.archives-ouvertes.fr/pasteur-00583295
Targeting of cell-surface ??-amyloid precursor protein to lysosomes:
alternative processing into amyloid-bearing fragments, Nature, vol.357, issue.6378, pp.500-503, 1992. ,
DOI : 10.1038/357500a0
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation, Nature Cell Biology, vol.18, issue.5, pp.461-466, 2003. ,
DOI : 10.1038/ncb983
A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling, Journal of Neuroscience Research, vol.10, issue.6, pp.655-667, 2002. ,
DOI : 10.1002/jnr.10263
Embryonic lethality in mice homozygous for a processingdeficient allele of Notch1, Nature, vol.405, pp.966-970, 2000. ,
Familial Alzheimer Disease-linked Presenilin 1 Variants Enhance Production of Both Abeta 1-40 and Abeta 1-42 Peptides That Are Only Partially Sensitive to a Potent Aspartyl Protease Transition State Inhibitor of "gamma -Secretase", Journal of Biological Chemistry, vol.278, issue.9, pp.7010-7018, 2003. ,
DOI : 10.1074/jbc.M209252200
Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta, Developmental Cell, vol.4, issue.1, pp.67-82, 2003. ,
DOI : 10.1016/S1534-5807(02)00409-4
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases, Trends in Cell Biology, vol.10, issue.10, pp.429-439, 2000. ,
DOI : 10.1016/S0962-8924(00)01834-1
Signalling downstream of activated mammalian Notch, Nature, vol.377, issue.6547, pp.355-358, 1995. ,
DOI : 10.1038/377355a0
c-Cbl Binding and Ubiquitin-dependent Lysosomal Degradation of Membrane-associated Notch1, Journal of Biological Chemistry, vol.277, issue.10, pp.8033-8040, 2002. ,
DOI : 10.1074/jbc.M108552200
Presenilin-1 affects trafficking and processing of ??APP and is targeted in a complex with nicastrin to the plasma membrane, The Journal of Cell Biology, vol.109, issue.3, pp.551-561, 2002. ,
DOI : 10.1038/35017108
??-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2, Proc. Natl. Acad. Sci. USA, pp.6382-6387, 2003. ,
DOI : 10.1073/pnas.1037392100
A Human Protein with Sequence Similarity to Drosophila Mastermind Coordinates the Nuclear Form of Notch and a CSL Protein To Build a Transcriptional Activator Complex on Target Promoters, Molecular and Cellular Biology, vol.21, issue.13, pp.4337-4346, 2001. ,
DOI : 10.1128/MCB.21.13.4337-4346.2001
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the ??-secretase ADAM 10, Proc. Natl. Acad. Sci. USA, pp.5815-5820, 2001. ,
DOI : 10.1073/pnas.081612998
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD, Development, vol.120, pp.2385-2396, 1994. ,
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain., Proc. Natl. Acad. Sci. USA, pp.1683-1688, 1996. ,
DOI : 10.1073/pnas.93.4.1683
Endogenous Presenilin-1 Targets to Endocytic Rather Than Biosynthetic Compartments, Molecular and Cellular Neuroscience, vol.16, issue.2, pp.111-126, 2000. ,
DOI : 10.1006/mcne.2000.0861
Protein Degradation: Four E3s For The Notch Pathway, Current Biology, vol.12, issue.2, pp.74-78, 2002. ,
DOI : 10.1016/S0960-9822(01)00679-0
Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Abeta -like Peptide, Journal of Biological Chemistry, vol.277, issue.47, pp.44754-44759, 2002. ,
DOI : 10.1074/jbc.M206872200
The Notch Ligands, Jagged and Delta, Are Sequentially Processed by ??-Secretase and Presenilin/??-Secretase and Release Signaling Fragments, Journal of Biological Chemistry, vol.278, issue.36, pp.34427-34437, 2003. ,
DOI : 10.1074/jbc.M302659200
The Notch1 receptor is cleaved constitutively by a furin-like convertase, Proc. Natl. Acad. Sci. USA, pp.8108-8112, 1998. ,
DOI : 10.1073/pnas.95.14.8108
Drosophila Nicastrin Is Essential for the Intramembranous Cleavage of Notch, Developmental Cell, vol.2, issue.1, pp.79-89, 2002. ,
DOI : 10.1016/S1534-5807(01)00109-5
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions, The EMBO Journal, vol.21, issue.8, pp.1948-1956, 2002. ,
DOI : 10.1093/emboj/21.8.1948
A CBP Binding Transcriptional Repressor Produced by the PS1/??-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations, Cell, vol.114, issue.5, pp.635-645, 2003. ,
DOI : 10.1016/j.cell.2003.08.008
Regulated Interactions between Dynamin and the Actin-Binding Protein Cortactin Modulate Cell Shape, The Journal of Cell Biology, vol.6, issue.1, pp.187-198, 2000. ,
DOI : 10.1083/jcb.120.6.1417
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on A??42 production, Proc. Natl. Acad. Sci. USA, pp.8025-8030, 2002. ,
DOI : 10.1073/pnas.112686799
Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation, Journal of Biological Chemistry, vol.278, issue.24, pp.21323-21326, 2003. ,
DOI : 10.1074/jbc.C300096200
A Ligand-Induced Extracellular Cleavage Regulates ??-Secretase-like Proteolytic Activation of Notch1, Molecular Cell, vol.5, issue.2, pp.197-206, 2000. ,
DOI : 10.1016/S1097-2765(00)80416-5
gamma -Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase, Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase, pp.2179-2181, 2001. ,
DOI : 10.1126/science.1065412
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway, Development, vol.127, pp.1373-1385, 2000. ,
Presenilin-1, Nicastrin, Amyloid Precursor Protein, and ??-Secretase Activity Are Co-localized in the Lysosomal Membrane, Journal of Biological Chemistry, vol.278, issue.29, pp.26687-26694, 2003. ,
DOI : 10.1074/jbc.M304009200
Mapping the APP/Presenilin (PS) Binding Domains: The Hydrophilic N-Terminus of PS2 Is Sufficient for Interaction with APP and Can Displace APP/PS1 Interaction, Neurobiology of Disease, vol.6, issue.1, pp.43-55, 1999. ,
DOI : 10.1006/nbdi.1998.0212
Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase, Journal of Biological Chemistry, vol.275, issue.46, pp.35734-35737, 2000. ,
DOI : 10.1074/jbc.M007300200
Cell Surface Presenilin-1 Participates in the ??-Secretase-like Proteolysis of Notch, Journal of Biological Chemistry, vol.274, issue.51, pp.36801-36807, 1999. ,
DOI : 10.1074/jbc.274.51.36801
Non-traditional Functions of Ubiquitin and Ubiquitin-binding Proteins, Journal of Biological Chemistry, vol.278, issue.38, pp.35857-35860, 2003. ,
DOI : 10.1074/jbc.R300018200
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain, Nature, vol.393, pp.382-386, 1998. ,
Requirement for Dynamin during Notch Signaling inDrosophilaNeurogenesis, Developmental Biology, vol.192, issue.2, pp.585-598, 1997. ,
DOI : 10.1006/dbio.1997.8723
Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans, Nature, vol.5, issue.6916, pp.686-690, 2002. ,
DOI : 10.1016/S0092-8674(01)00375-0
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and ??-secretase, Proc. Natl. Acad. Sci. USA, pp.7638-7643, 2003. ,
DOI : 10.1073/pnas.1230693100
Presenilin 1 Negatively Regulates ??-Catenin/T Cell Factor/Lymphoid Enhancer Factor-1 Signaling Independently of ??-Amyloid Precursor Protein and Notch Processing, The Journal of Cell Biology, vol.8, issue.4, pp.785-794, 2001. ,
DOI : 10.1016/S1097-2765(00)80200-2
Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins, Molecular Cell, vol.6, issue.3, pp.625-636, 2000. ,
DOI : 10.1016/S1097-2765(00)00061-7
Notch receptor cleavage depends on but is not directly executed by presenilins, Proc. Natl. Acad. Sci. USA, pp.4014-4019, 2002. ,
DOI : 10.1073/pnas.052017699
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122640
Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz, Genes & Development, vol.16, issue.2, pp.222-234, 2002. ,
DOI : 10.1101/gad.214202
Intramembrane proteolysis controls diverse signalling pathways throughout evolution, Current Opinion in Genetics & Development, vol.12, issue.5, pp.512-518, 2002. ,
DOI : 10.1016/S0959-437X(02)00334-9
A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands, The EMBO Journal, vol.21, issue.16, pp.4277-4286, 2002. ,
DOI : 10.1093/emboj/cdf434
A Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's ??-Secretase Activity, Journal of Medicinal Chemistry, vol.41, issue.1, pp.6-9, 1998. ,
DOI : 10.1021/jm970621b
A fluid connection: Cholesterol and A??, Proc. Natl. Acad. Sci. USA. 98, pp.5371-5373, 2001. ,
DOI : 10.1073/pnas.101123198
A conserved catalytic residue in the ubiquitin-conjugating enzyme family, The EMBO Journal, vol.22, issue.19, pp.5241-5250, 2003. ,
DOI : 10.1093/emboj/cdg501
Mature Glycosylation and Trafficking of Nicastrin Modulate Its Binding to Presenilins, Journal of Biological Chemistry, vol.277, issue.31, pp.28135-28142, 2002. ,
DOI : 10.1074/jbc.M110871200
Subcellular Distribution and Turnover of Presenilins in Transfected Cells, Journal of Biological Chemistry, vol.273, issue.20, pp.12436-12442, 1998. ,
DOI : 10.1074/jbc.273.20.12436