B. Rocha, N. Dautigny, and P. Pereira, Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratiosin vivo, European Journal of Immunology, vol.328, issue.5, pp.905-911, 1989.
DOI : 10.1002/eji.1830190518

B. Ernst, D. Lee, J. Chang, J. Sprent, and C. Surh, The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery, Immunity, vol.11, issue.2, pp.173-181, 1999.
DOI : 10.1016/S1074-7613(00)80092-8

A. Goldrath and M. Bevan, Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts, Immunity, vol.11, issue.2, pp.183-190, 1999.
DOI : 10.1016/S1074-7613(00)80093-X

J. Tan, E. Dudl, E. Leroy, R. Murray, and J. Sprent, IL-7 is critical for homeostatic proliferation and survival of naive T cells, Proceedings of the National Academy of Sciences, vol.98, issue.15, pp.8732-8737, 2001.
DOI : 10.1073/pnas.161126098

K. Schluns, W. Kieper, S. Jameson, and L. Lefrancois, Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo, Nature Immunology, vol.1, issue.5, pp.426-432, 2000.
DOI : 10.1038/80868

B. Seddon, P. Tomlinson, and R. Zamoyska, Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells, Nature Immunology, vol.4, issue.7, pp.680-686, 2003.
DOI : 10.1038/ni946

S. Jameson, Maintaining the norm: T-cell homeostasis, Nat Rev Immunol, vol.2, pp.547-556, 2002.

Y. Hao, N. Legrand, and A. Freitas, The clone size of peripheral CD8 T cells is regulated by TCR promiscuity, The Journal of Experimental Medicine, vol.2, issue.7, pp.1643-1649, 2006.
DOI : 10.1084/jem.185.12.2043

URL : https://hal.archives-ouvertes.fr/pasteur-00161684

L. Gruta, N. Driel, I. Gleeson, and P. , Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire, European Journal of Immunology, vol.178, issue.12, pp.3380-3386, 2000.
DOI : 10.1002/1521-4141(2000012)30:12<3380::AID-IMMU3380>3.0.CO;2-P

A. Goldrath, C. Luckey, R. Park, C. Benoist, and D. Mathis, The molecular program induced in T cells undergoing homeostatic proliferation, Proceedings of the National Academy of Sciences, vol.101, issue.48, pp.16885-16890, 2004.
DOI : 10.1073/pnas.0407417101

C. Tanchot, L. Campion, A. Martin, B. Leaument, S. Dautigny et al., Conversion of Naive T Cells to a Memory-Like Phenotype in Lymphopenic Hosts Is Not Related to a Homeostatic Mechanism That Fills the Peripheral Naive T Cell Pool, The Journal of Immunology, vol.168, issue.10, pp.5042-5046, 2002.
DOI : 10.4049/jimmunol.168.10.5042

K. Maloy and F. Powrie, Regulatory T cells in the control of immune pathology, Nature Immunology, vol.26, issue.9, pp.816-822, 2001.
DOI : 10.1038/ni0901-816

C. King, A. Ilic, K. Koelsch, and N. Sarvetnick, Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity, Cell, vol.117, issue.2, pp.265-277, 2004.
DOI : 10.1016/S0092-8674(04)00335-6

A. Almeida, B. Zaragoza, and A. Freitas, Indexation as a Novel Mechanism of Lymphocyte Homeostasis: The Number of CD4+CD25+ Regulatory T Cells Is Indexed to the Number of IL-2-Producing Cells, The Journal of Immunology, vol.177, issue.1, pp.192-200, 2006.
DOI : 10.4049/jimmunol.177.1.192

URL : https://hal.archives-ouvertes.fr/pasteur-00161683

F. Sallusto, D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia, Two subsets of memory T lymphocytes with distinct homing potentials and effector functions, Nature, vol.9, issue.6754, pp.708-712, 1999.
DOI : 10.1038/44385

S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda, Immunologic selftolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25) Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, Journal of Immunology, vol.155, pp.1151-1164, 1995.

E. Shevach, Regulatory T Cells in Autoimmmunity, Annual Review of Immunology, vol.18, issue.1, pp.423-449, 2000.
DOI : 10.1146/annurev.immunol.18.1.423

A. Freitas and B. Rocha, Population Biology of Lymphocytes: The Flight for Survival, Annual Review of Immunology, vol.18, issue.1, pp.83-111, 2000.
DOI : 10.1146/annurev.immunol.18.1.83

URL : https://hal.archives-ouvertes.fr/hal-00108283

S. Hamilton and S. Jameson, The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8+ T cells, Proceedings of the National Academy of Sciences, vol.105, issue.47, pp.18484-18489, 2008.
DOI : 10.1073/pnas.0806487105

C. Bourgeois, B. Rocha, and C. Tanchot, A Role for CD40 Expression on CD8+ T Cells in the Generation of CD8+ T Cell Memory, Science, vol.297, issue.5589, pp.2060-2063, 2002.
DOI : 10.1126/science.1072615

M. Bevan, Helping the CD8+ T-cell response, Nature Reviews Immunology, vol.270, issue.8, pp.595-602, 2004.
DOI : 10.1038/nri11308

M. Mingueneau, R. Roncagalli, C. Gregoire, A. Kissenpfennig, and A. Miazek, Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell Receptor, Immunity, vol.31, issue.2, pp.197-208, 2009.
DOI : 10.1016/j.immuni.2009.05.013

URL : https://hal.archives-ouvertes.fr/hal-00432068

A. Almeida, N. Legrand, M. Papiernik, and A. Freitas, Homeostasis of Peripheral CD4+ T Cells: IL-2R?? and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers, The Journal of Immunology, vol.169, issue.9, pp.4850-4860, 2002.
DOI : 10.4049/jimmunol.169.9.4850

URL : https://hal.archives-ouvertes.fr/pasteur-00327445

A. Peixoto, M. Monteiro, B. Rocha, and H. Veiga-fernandes, Quantification of Multiple Gene Expression in Individual Cells, Genome Research, vol.14, issue.10a, pp.1938-1947, 2004.
DOI : 10.1101/gr.2890204

H. Veiga-fernandes, U. Walter, C. Bourgeois, A. Mclean, and B. Rocha, Response of naive and memory CD8+ T cells to antigen stimulation in vivo, Nature Immunology, vol.1, issue.1, pp.47-53, 2000.
DOI : 10.1038/76907

A. Peixoto, C. Evaristo, I. Munitic, M. Monteiro, and A. Charbit, CD8 single-cell gene coexpression reveals three different effector types present at distinct phases of the immune response, The Journal of Experimental Medicine, vol.162, issue.5, pp.1193-1205, 2007.
DOI : 10.4049/jimmunol.172.12.7239

J. Helft, A. Jacquet, N. Joncker, I. Grandjean, and G. Dorothee, Antigen-specific T-T interactions regulate CD4 T-cell expansion, Blood, vol.112, issue.4, pp.1249-1258, 2008.
DOI : 10.1182/blood-2007-09-114389

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515122

J. Sun, M. Williams, and M. Bevan, CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection, Nature Immunology, vol.92, issue.9, pp.927-933, 2004.
DOI : 10.1016/S1074-7613(00)80470-7

R. Noelle, CD40 and Its Ligand in Host Defense, Immunity, vol.4, issue.5, pp.415-419, 1996.
DOI : 10.1016/S1074-7613(00)80408-2

URL : http://doi.org/10.1016/s1074-7613(00)80408-2

I. Grewal and R. Flavell, CD40 AND CD154 IN CELL-MEDIATED IMMUNITY, Annual Review of Immunology, vol.16, issue.1, pp.111-135, 1998.
DOI : 10.1146/annurev.immunol.16.1.111

F. Castellino, A. Huang, G. Altan-bonnet, S. Stoll, and C. Scheinecker, Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell???dendritic cell interaction, Nature, vol.3, issue.7086, pp.890-895, 2006.
DOI : 10.1038/nature04651

G. Kolumam, S. Thomas, L. Thompson, J. Sprent, and K. Murali-krishna, Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection, The Journal of Experimental Medicine, vol.4, issue.5, pp.637-650, 2005.
DOI : 10.1038/37648

M. Kopf, H. Baumann, G. Freer, M. Freudenberg, and M. Lamers, Impaired immune and acute-phase responses in interleukin-6-deficient mice, Nature, vol.368, issue.6469, pp.339-342, 1994.
DOI : 10.1038/368339a0

P. Antony, C. Piccirillo, A. Akpinarli, S. Finkelstein, and P. Speiss, CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells, The Journal of Immunology, vol.174, issue.5, pp.2591-2601, 2005.
DOI : 10.4049/jimmunol.174.5.2591

M. Williams, A. Tyznik, and M. Bevan, Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells, Nature, vol.8, issue.7095, pp.890-893, 2006.
DOI : 10.1038/nature04790

S. Hamilton, M. Wolkers, S. Schoenberger, and S. Jameson, The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells, Nature Immunology, vol.191, issue.5, pp.475-481, 2006.
DOI : 10.1038/ni1326

C. Piccirillo and E. Shevach, Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells, The Journal of Immunology, vol.167, issue.3, pp.1137-1140, 2001.
DOI : 10.4049/jimmunol.167.3.1137

M. Kursar, K. Bonhagen, J. Fensterle, A. Kohler, and R. Hurwitz, T Cell Responses, The Journal of Experimental Medicine, vol.59, issue.12, pp.1585-1592, 2002.
DOI : 10.1046/j.1523-1747.2000.00156.x

M. Murakami, A. Sakamoto, J. Bender, J. Kappler, and P. Marrack, CD25+CD4+ T cells contribute to the control of memory CD8+ T cells, Proceedings of the National Academy of Sciences, vol.99, issue.13, pp.8832-8837, 2002.
DOI : 10.1073/pnas.132254399

K. Hagen, C. Moses, E. Drasler, K. Podetz-pedersen, and S. Jameson, A Role for CD28 in Lymphopenia-Induced Proliferation of CD4 T Cells, The Journal of Immunology, vol.173, issue.6, pp.3909-3915, 2004.
DOI : 10.4049/jimmunol.173.6.3909

L. Diehl, A. Boer, S. Schoenberger, E. Van-der-voort, and T. Schumacher, CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy, Nature Medicine, vol.5, issue.7, pp.774-779, 1999.
DOI : 10.1038/10495

R. French, H. Chan, A. Tutt, and M. Glennie, CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help, Nat Med, vol.5, pp.548-553, 1999.

F. Castellino and R. Germain, T CELLS: When, Where, and How, Annual Review of Immunology, vol.24, issue.1, pp.519-540, 2006.
DOI : 10.1146/annurev.immunol.23.021704.115825

F. Cocchi, A. Devico, A. Garzino-demo, S. Arya, and R. Gallo, Identification of RANTES, MIP-1alpha, and MIP-1beta as the Major HIV-Suppressive Factors Produced by CD8+ T Cells, Science, vol.270, issue.5243, pp.1811-1815, 1995.
DOI : 10.1126/science.270.5243.1811

J. Tan, B. Ernst, W. Kieper, E. Leroy, and J. Sprent, Cells, The Journal of Experimental Medicine, vol.20, issue.12, pp.1523-1532, 2002.
DOI : 10.1182/blood.V97.10.2983

URL : https://hal.archives-ouvertes.fr/hal-01452927

W. Kieper, A. Troy, J. Burghardt, C. Ramsey, and J. Lee, Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion, The Journal of Immunology, vol.174, issue.6, pp.3158-3163, 2005.
DOI : 10.4049/jimmunol.174.6.3158

M. Tajima, D. Wakita, D. Noguchi, K. Chamoto, and Z. Yue, T cells, The Journal of Experimental Medicine, vol.158, issue.5, pp.1019-1027, 2008.
DOI : 10.4049/jimmunol.164.9.4878

J. Cho, O. Boyman, H. Kim, B. Hahm, and M. Rubinstein, cells driven by IL-2, The Journal of Experimental Medicine, vol.87, issue.8, 2007.
DOI : 10.1016/j.immuni.2005.01.005

H. Schorle, T. Holtschke, T. Hunig, A. Schimpl, and I. Horak, Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting, Nature, vol.352, issue.6336, pp.621-624, 1991.
DOI : 10.1038/352621a0

V. Vezys, A. Yates, K. Casey, G. Lanier, and R. Ahmed, Memory CD8 T-cell compartment grows in size with immunological experience, Nature, vol.69, issue.7226, pp.196-199, 2009.
DOI : 10.1038/nature07486

L. Selin, M. Lin, K. Kraemer, D. Pardoll, and J. Schneck, Attrition of T Cell Memory, Immunity, vol.11, issue.6, pp.733-742, 1999.
DOI : 10.1016/S1074-7613(00)80147-8