Cell-to-Cell Interactions and Signals Involved in the Reconstitution of Peripheral CD8 T(CM) and T(EM) Cell Pools. - Archive ouverte HAL Access content directly
Journal Articles PLoS ONE Year : 2011

Cell-to-Cell Interactions and Signals Involved in the Reconstitution of Peripheral CD8 T(CM) and T(EM) Cell Pools.

(1) , (2) , (3) , (4) , (3) , (2) , (1) , (1)
1
2
3
4

Abstract

We here describe novel aspects of CD8(+) and CD4(+) T cell subset interactions that may be clinically relevant and provide new tools for regulating the reconstitution of the peripheral CD8(+) T cell pools in immune-deficient states. We show that the reconstitution capacity of transferred isolated naïve CD8(+) T cells and their differentiation of effector functions is limited, but both dramatically increase upon the co-transfer of CD4(+) T cells. This helper effect is complex and determined by multiple factors. It was directly correlated to the number of helper cells, required the continuous presence of the CD4(+) T cells, dependent on host antigen-presenting cells (APCs) expressing CD40 and on the formation of CD4/CD8/APC cell clusters. By comparing the recovery of (CD44(+)CD62L(high)) T(CM) and (CD44(+)CD62L(low)) T(EM) CD8(+) T cells, we found that the accumulation of T(CM) and T(EM) subsets is differentially regulated. T(CM)-cell accumulation depended mainly on type I interferons, interleukin (IL)-6, and IL-15, but was independent of CD4(+) T-cell help. In contrast, T(EM)-cell expansion was mainly determined by CD4(+) T-cell help and dependent on the expression of IL-2Rβ by CD8 cells, on IL-2 produced by CD4(+) T-cells, on IL-15 and to a minor extent on IL-6.
Fichier principal
Vignette du fichier
journal.pone.0017423.pdf (1.12 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

pasteur-00579198 , version 1 (23-03-2011)

Identifiers

Cite

Bruno Zaragoza, César Evaristo, Adrien Kissenpfennig, Valentina Libri, Bernard Malissen, et al.. Cell-to-Cell Interactions and Signals Involved in the Reconstitution of Peripheral CD8 T(CM) and T(EM) Cell Pools.. PLoS ONE, 2011, 6 (3), pp.e17423. ⟨10.1371/journal.pone.0017423⟩. ⟨pasteur-00579198⟩
188 View
248 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More