Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice.

Maud D Demarque (1) , Karim Nacerddine (1) , Hélène Neyret-Kahn (1) , Alexandra Andrieux (1) , Esther Danenberg (2) , Grégory Jouvion (3) , Perrine Bomme (4) , Ghislaine Hamard (5) , Béatrice Romagnolo (6) , Benoît Terris (7) , Ana Cumano (8) , Nick Barker (2) , Hans Clevers (2) , Anne Dejean (1)

1 Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis
2 Hubrecht Institute for Developmental Biology and Stem Cell Research
3 Histotechnologie et Pathologie
4 Microscopie Ultrastructurale (Plate-forme)
5 PRHTEC - Plateforme Recombinaison Homologue, Transfert d'Embryons et Cryoconservation [Institut Cochin]
6 UMR_S567 / UMR 8104 - Institut Cochin
7 Service d'Anatomie Pathologique
8 Développement des Lymphocytes

Sumoylation maintains intestinal stem cells and the architecture, mechanical stability, and function of the intestinal epithelium of mice.

Domains: Life Sciences [q-bio]; Immunology

Maud D Demarque, Karim Nacerddine, Hélène Neyret-Kahn, Alexandra Andrieux, Esther Danenberg, et al.. Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice.. Gastroenterology, 2011, 140 (1), pp.286-96. ⟨10.1053/j.gastro.2010.10.002⟩. ⟨pasteur-00572277⟩