R. Allam, R. Pawar, O. Kulkarni, V. Hornung, G. Hartmann et al., Viral 5???-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses, European Journal of Immunology, vol.205, issue.12, pp.3487-3498, 2008.
DOI : 10.1002/eji.200838604

E. Baechler, F. Batliwalla, G. Karypis, P. Gaffney, W. Ortmann et al., Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus, Proceedings of the National Academy of Sciences, vol.100, issue.5, pp.2610-2615, 2003.
DOI : 10.1073/pnas.0337679100

J. Bates, C. Lessard, J. Leon, T. Nguyen, L. Battiest et al., Meta-analysis and imputation identifies a 109???kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations, Genes and Immunity, vol.156, issue.5, pp.470-477, 2009.
DOI : 10.1038/ng2088

M. Botto, C. Dell-'agnola, A. Bygrave, E. Thompson, H. Cook et al., Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies, Nature Genetics, vol.84, issue.1, pp.56-59, 1998.
DOI : 10.1016/0022-1759(90)90380-E

M. Crow, Developments in the clinical understanding of lupus, Arthritis Research & Therapy, vol.11, issue.5, p.245, 2009.
DOI : 10.1186/ar2762

M. Crow, K. Kirou, and J. Wohlgemuth, Microarray Analysis of Interferon-regulated Genes in SLE, Autoimmunity, vol.14, issue.8, pp.481-490, 2003.
DOI : 10.1002/ana.1096

J. Deane and S. Bolland, Nucleic Acid-Sensing TLRs as Modifiers of Autoimmunity, The Journal of Immunology, vol.177, issue.10, pp.6573-6578, 2006.
DOI : 10.4049/jimmunol.177.10.6573

R. Graham, G. Hom, W. Ortmann, and T. Behrens, Review of recent genome-wide association scans in lupus, Journal of Internal Medicine, vol.32, issue.6, pp.680-688, 2009.
DOI : 10.1111/j.1365-2796.2009.02096.x

J. Harley, M. Alarcon-riquelme, L. Criswell, C. Jacob, R. Kimberly et al., Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci, Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci, pp.204-210, 2008.
DOI : 10.1038/ng.81

D. Hinds, L. Stuve, G. Nilsen, E. Halperin, E. Eskin et al., Whole-Genome Patterns of Common DNA Variation in Three Human Populations, Science, vol.307, issue.5712, pp.1072-1079, 2005.
DOI : 10.1126/science.1105436

J. Hiscott, R. Lin, P. Nakhaei, and S. Paz, MasterCARD: a priceless link to innate immunity, Trends in Molecular Medicine, vol.12, issue.2, pp.53-56, 2006.
DOI : 10.1016/j.molmed.2005.12.003

J. Hooks, H. Moutsopoulos, S. Geis, N. Stahl, J. Decker et al., Immune Interferon in the Circulation of Patients with Autoimmune Disease, New England Journal of Medicine, vol.301, issue.1, pp.5-8, 1979.
DOI : 10.1056/NEJM197907053010102

S. Kariuki, K. Kirou, E. Macdermott, L. Barillas-arias, M. Crow et al., Cutting Edge: Autoimmune Disease Risk Variant of STAT4 Confers Increased Sensitivity to IFN-?? in Lupus Patients In Vivo, The Journal of Immunology, vol.182, issue.1, pp.34-38, 2009.
DOI : 10.4049/jimmunol.182.1.34

S. Kariuki, B. Franek, R. Mikolaitis, T. Utset, M. Jolly et al., Promoter Variant of PIK3C3 is Associated with Autoimmunity Against Ro and Sm Epitopes in African-american Lupus Patients, Clinical Immunology, vol.135, p.826434, 2010.
DOI : 10.1016/j.clim.2010.03.166

T. Kawai, K. Takahashi, S. Sato, C. Coban, H. Kumar et al., IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction, Nature Immunology, vol.174, issue.10, pp.981-988, 2005.
DOI : 10.1093/emboj/cdf505

K. Kirou, C. Lee, S. George, K. Louca, I. Papagiannis et al., Coordinate overexpression of interferon-?-induced genes in systemic lupus erythematosus, Arthritis & Rheumatism, vol.19, issue.12, pp.3958-3967, 2004.
DOI : 10.1002/art.20798

K. Kirou, C. Lee, S. George, K. Louca, M. Peterson et al., Activation of the interferon-?? pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease, Arthritis & Rheumatism, vol.19, issue.5, pp.1491-1503, 2005.
DOI : 10.1002/art.21031

L. Goffic, R. Pothlichet, J. Vitour, D. Fujita, T. Meurs et al., Cutting Edge: Influenza A Virus Activates TLR3-Dependent Inflammatory and RIG-I-Dependent Antiviral Responses in Human Lung Epithelial Cells, The Journal of Immunology, vol.178, issue.6, pp.3368-3372, 2007.
DOI : 10.4049/jimmunol.178.6.3368

C. Moore, D. Bergstralh, J. Duncan, Y. Lei, T. Morrison et al., NLRX1 is a regulator of mitochondrial antiviral immunity, Nature, vol.104, issue.7178, pp.573-577, 2008.
DOI : 10.1038/nature06501

P. Nakhaei, T. Mesplede, M. Solis, Q. Sun, T. Zhao et al., The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation, PLoS Pathogens, vol.276, issue.11, p.1000650, 2009.
DOI : 10.1371/journal.ppat.1000650.s004

T. Niewold, J. Hua, T. Lehman, J. Harley, and M. Crow, High serum IFN-?? activity is a heritable risk factor for systemic lupus erythematosus, Genes and Immunity, vol.13, issue.6, pp.492-502, 2007.
DOI : 10.1038/sj.gene.6364408

T. Niewold, J. Kelly, M. Flesch, L. Espinoza, J. Harley et al., Association of the IRF5 risk haplotype with high serum interferon-?? activity in systemic lupus erythematosus patients, Arthritis & Rheumatism, vol.50, issue.8, pp.2481-2487, 2008.
DOI : 10.1002/art.23613

T. Niewold, T. Rivera, J. Buyon, and M. Crow, Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro???positive mothers of children with neonatal lupus, Arthritis & Rheumatism, vol.8, issue.2, pp.541-546, 2008.
DOI : 10.1002/art.23191

Y. Okabe, T. Sano, and S. Nagata, Regulation of the innate immune response by threoninephosphatase of Eyes absent, Nature, vol.460, pp.520-524, 2009.

B. Poole, R. Scofield, J. Harley, and J. James, Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus, Autoimmunity, vol.24, issue.2, pp.63-70, 2006.
DOI : 10.1186/ar1181

D. Posnett, Herpesviruses and autoimmunity, Curr Opin Investig Drugs, vol.9, pp.505-514, 2008.

J. Pothlichet, A. Burtey, A. Kubarenko, G. Caignard, B. Solhonne et al., Study of Human RIG-I Polymorphisms Identifies Two Variants with an Opposite Impact on the Antiviral Immune Response, PLoS ONE, vol.4, issue.10, p.7582, 2009.
DOI : 10.1371/journal.pone.0007582.s004

URL : https://hal.archives-ouvertes.fr/pasteur-00455204

J. Pothlichet, M. Chignard, and M. Si-tahar, Cutting Edge: Innate Immune Response Triggered by Influenza A Virus Is Negatively Regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-Dependent Pathway, The Journal of Immunology, vol.180, issue.4, pp.2034-2038, 2008.
DOI : 10.4049/jimmunol.180.4.2034

URL : https://hal.archives-ouvertes.fr/pasteur-00206322

M. Visa, Cardif caspase activation recruitment domain, BMC structural biology, vol.8, p.11

M. Ramos-casals, M. Cuadrado, P. Alba, G. Sanna, P. Brito-zeron et al., Acute Viral Infections in Patients With Systemic Lupus Erythematosus, Medicine, vol.87, issue.6, pp.311-318, 2008.
DOI : 10.1097/MD.0b013e31818ec711

S. Saha, E. Pietras, J. He, J. Kang, S. Liu et al., Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif, The EMBO Journal, vol.5, issue.14, pp.3257-3263, 2006.
DOI : 10.1038/sj.emboj.7601220

R. Salloum, B. Franek, S. Kariuki, L. Rhee, R. Mikolaitis et al., Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-?? activity in lupus patients, Arthritis & Rheumatism, vol.349, issue.2, pp.553-561, 2010.
DOI : 10.1002/art.27182

M. Samanta, D. Iwakiri, T. Kanda, T. Imaizumi, and K. Takada, EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN, The EMBO Journal, vol.10, issue.18, pp.4207-4214, 2006.
DOI : 10.1038/ni1087

G. Sebastiani and M. Galeazzi, Immunogenetic studies on systemic lupus erythematosus, Lupus, vol.18, issue.10, pp.878-883, 2009.
DOI : 10.1177/0961203309106918

R. Seth, L. Sun, C. Ea, and Z. Chen, Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-??B and IRF3, Cell, vol.122, issue.5, pp.669-682, 2005.
DOI : 10.1016/j.cell.2005.08.012

E. Tan, A. Cohen, J. Fries, A. Masi, D. Mcshane et al., The 1982 revised criteria for the classification of systemic lupus erythematosus, Arthritis & Rheumatism, vol.31, issue.11, pp.1271-1277, 1982.
DOI : 10.1002/art.1780251101

C. Gallego, J. Banchereau, L. Abel, X. Li, D. Chaussabel et al., Pyogenic bacterial infections in humans with MyD88 deficiency, Science, vol.321, pp.691-696, 2008.

C. Werts, S. Girardin, and D. Philpott, TIR, CARD and PYRIN: three domains for an antimicrobial triad, Cell Death and Differentiation, vol.171, issue.5, pp.798-815, 2006.
DOI : 10.1074/jbc.M204885200

M. Yoneyama, M. Kikuchi, T. Natsukawa, N. Shinobu, T. Imaizumi et al., The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses, Nature Immunology, vol.120, issue.7, pp.730-737, 2004.
DOI : 10.1038/ni910

T. Zhao, L. Yang, Q. Sun, M. Arguello, D. Ballard et al., The NEMO adaptor bridges the nuclear factor-??B and interferon regulatory factor signaling pathways, Nature Immunology, vol.78, issue.6, pp.592-600, 2007.
DOI : 10.1038/ni1465