Skip to Main content Skip to Navigation
New interface
Journal articles

Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures.

Lark L Coffey 1 Marco Vignuzzi 1, * 
* Corresponding author
Abstract : Mechanisms by which RNA arboviruses including chikungunya virus (CHIKV) evolve and maintain the ability to infect vertebrate and invertebrate hosts are poorly understood. To understand how host specificity shapes arbovirus populations, we studied CHIKV populations passaged between invertebrate↔vertebrate cells to simulate natural alternation, contrasted with populations that were artificially released from cycling by passage in single cell types. These CHIKV populations were characterized by measuring genetic diversity, changes in fitness, and adaptability to novel selective pressures. The greatest fitness increases were observed in alternately passaged CHIKV, without drastic changes in population diversity. The greatest increases in genetic diversity were observed after serial passage and correlated with greater adaptability. These results suggest an evolutionary trade-off between maintaining fitness for invertebrate↔vertebrate cycling, where maximum adaptability is only possible via enhanced population diversity and extensive exploration of sequence space.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-00546712
Contributor : Mireille Gau Connect in order to contact the contributor
Submitted on : Tuesday, December 14, 2010 - 4:09:16 PM
Last modification on : Thursday, April 7, 2022 - 10:10:19 AM

Links full text

Identifiers

Collections

Citation

Lark L Coffey, Marco Vignuzzi. Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures.. Journal of Virology, 2010, epub ahead of print. ⟨10.1128/JVI.01918-10⟩. ⟨pasteur-00546712⟩

Share

Metrics

Record views

27